Correlation between clinical findings and eosinophil/neutrophil ratio in patients with nasal polyps

Tecimer, S. Hancer; Kasapoğlu, Fikret; Demir, Uygar; Ozmen, Omer Afşın; Çoşkun, Hakan; Basut, Oğuz

doi:10.1007/s00405-014-3174-4

Cited by 39 publications

(35 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings were in accordance with the findings of a study that reported that patients with CRSwNP demonstrated systemic eosinophilic inflammation [18]. In conclusion, EOS is a significant factor related to the morbidity of CRSwNP.…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

Chen

Qiao

et al. 2019

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: Nasal polyps are a common health problem that can significantly impact the quality of life. Objective: To analyze the impact of allergy and peripheral eosinophils (EOS) on the morbidity of chronic rhinosinusitis with nasal polyps (CRSwNP) in Northwest China. Methods: A retrospective cohort of 323 patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis without nasal polyps (CRSsNP) and CRSwNP in Xijing Hospital was studied between January 5, 2011, and January 4, 2015. All of the patients underwent an allergen skin prick test and peripheral blood EOS inspection. Detailed information regarding the impact of allergy and EOS on the morbidity of CRSwNP was collected. Potential risk factors associated with nasal polyps were explored using logistic regression analysis. Multivariate logistic regression was performed to identify independent risk factors. Results: The results revealed that EOS is an important risk factor for nasal polyps. In the univariate analysis, the adjusted OR was 2.01 (95% CI 1.08–3.72; p = 0.027). In the multivariate analysis, the adjusted OR was 2.02 (95% CI 1.08–3.76; p = 0.027). Compared to allergic rhinitis and normal EOS levels, nonallergic rhinitis and elevated EOS levels constituted a risk factor for CRSwNP (OR = 2.70; 95% CI 1.32–5.50). Compared to allergen-positive and EOS-normal status, allergen-negative and elevated-EOS status constituted a risk factor for CRSwNP (OR = 2.95; 95% CI 1.38–6.33). Conclusion: EOS is a significant factor related to the morbidity of CRSwNP in Northwest China. Elevated EOS levels occurring in the context of nonallergic rhinitis constitute a risk factor for CRSwNP. Similarly, elevated EOS levels occurring in the context of allergen-negative rhinitis are also an important risk factor for morbidity of CRSwNP.

show abstract

Section: Discussionsupporting

confidence: 83%

“…Allergic rhinitis diagnostic criteria [18] include: nasal itching, sneezing, nasal discharge, and nasal obstruction, among other symptoms, and a positive allergen sensitization SPT.…”

Section: Methodsmentioning

confidence: 99%

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

Chen

Qiao

et al. 2019

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…Therefore, we can conclude that eosinophils may trigger a more severe form of inflammation in the context of CRSwNP compared to the noneosinophilic inflammatory cells. However, our results showed no significant difference between the ECRSwNP and nECRSwNP groups with respect to the SNOT-20 score, VAS score, endoscopy score, or CT score ( p > 0.05); these findings are consistent with the results of a recently published paper that compared the clinical markers of CRS with disease severity [21,22,23]. …”

Section: Discussionsupporting

confidence: 82%

IL-33 Expression in Chronic Rhinosinusitis with Nasal Polyps and Its Relationship with Clinical Severity

Song

Wang²,

Zhou³

et al. 2017

ORL

View full text Add to dashboard Cite

Background: Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by epithelial inflammation and tissue eosinophilic infiltration. Interleukin-33 (IL-33) is a key inflammatory cytokine that mediates eosinophilic infiltration. Objective: The aim of our study was to investigate the expression and role of IL-33 in eosinophilic CRS with nasal polyps (ECRSwNP) and in noneosinophilic CRS with nasal polyps (nECRSwNP), and to analyze their correlation with clinical severity. Methods: The study enrolled 25 patients with ECRSwNP, 27 patients with nECRSwNP, and 12 control subjects, based on immunohistochemical staining. Protein and mRNA expressions of IL-33 in sinus mucosal samples were determined by immunohistochemistry and real-time polymerase chain reaction. Sino-Nasal Outcome Test-20 (SNOT-20) score, visual analog scale (VAS) score, endoscopy score, and computed tomography (CT) score were assessed preoperatively. Results: IL-33 expression levels in the CRSwNP group were significantly higher than those in the control group (p < 0.01), especially in the ECRSwNP group (p < 0.05). There were no significant differences between the ECRSwNP and nECRSwNP groups with respect to SNOT-20 score, VAS score, endoscopy score, or CT score. IL-33 mRNA expression showed a positive correlation with the number of eosinophils (p < 0.05) and endoscopy score (p < 0.05) but not with VAS score and CT score. Conclusion: IL-33 expression plays an important role in patients with CRSwNP. No significant differences were observed between the ECRSwNP and nECRSwNP groups with respect to SNOT-20 score, VAS score, endoscopy score, or CT score. IL-33 expression was correlated with eosinophil counts and endoscopy score.

show abstract

“…Indeed, our own study has shown that the ratio of CT scores for the ethmoid sinus and maxillary sinus (E/M ratio) based on Lund‐Mackay scores had the highest predictive value for ECRS compared with other clinical parameters . Although these studies clearly demonstrate the benefit and accuracy of CT scan in diagnosis of ECRS, and several studies have demonstrated a close association between ECRS and CRS recurrence, none have directly assessed the association between specific CT scan characteristics and CRSwNP recurrence. Thus, in the present study we investigated the correlations between findings of CT scans and CRSwNP recurrence and found that a cut‐off value of 2.55 for E/M ratio on CT scan had the highest predictive value for CRSwNP recurrence, with a sensitivity of 95.8% and a specificity of 91.1%, suggesting an E/M ratio >2.55 was indicative of the likelihood of CRSwNP recurring, even after adequate surgery and postsurgical management with normative intranasal corticosteroid and up to 2 short courses of antibiotics or systemic corticosteroids.…”

Section: Discussionmentioning

confidence: 93%

“…Furthermore, obtaining the tissue is not convenient in the outpatient clinic. Second, irrespective of whether percentage of tissue eosinophils is employed for the diagnosis of ECRS or prediction for CRS recurrence, the criterion for tissue eosinophilia percentage has been shown to range from 5% to 50%, which makes it difficult to define a reliable measure. From this standpoint, the E/M ratio appears to be superior to tissue eosinophil percentage as a prognostic indicator for CRS recurrence.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of computed tomography in the recurrence of chronic rhinosinusitis with nasal polyps

Meng

Zhang

Lou

2019

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is a nasal disease with a high tendency for recurrence. The aim of this study was to compare the use of computed tomography (CT) scan with other clinical parameters in predicting the recurrence of CRSwNP. Methods A total of 272 consecutive CRSwNP patients undergoing endoscopic functional sinus surgery were recruited. The demographic characteristics and clinical parameters, including CT scores, level of exhaled nitric oxide, and peripheral eosinophilia, were recorded. The degree of infiltration of inflammatory cells in the sinus mucosa was evaluated. Results Two hundred thirty of the 272 patients completed the study (118 patients with recurrence and 112 patients with no recurrence). The average follow‐up time was 24 months after the first surgery. The 2 groups were not significantly different with respect to age, gender distribution, comorbid allergy, exhaled oral fractional exhaled nitric oxide levels, nasal obstruction/runny nose/headache/facial pain scores, Lund‐Mackay score, peripheral eosinophil percentage, and peripheral eosinophil absolute count. The onset of surgical history and asthma, visual analog scores of CRS, anosmia score, ratio of total ethmoid sinus scores for both sides and maxillary sinus score for both sides (E/M ratio), Lund‐Kennedy score, tissue eosinophil percentage, and tissue eosinophil absolute count were significantly higher in the recurrence group. The E/M ratio showed high accuracy as a predictor for CRSwNP recurrence. The cut‐off point of 2.55 for E/M ratio indicated the highest predictive value of CRSwNP recurrence. Conclusion The E/M ratio is a useful predictor for the recurrence of CRSwNP in the Chinese population.

show abstract

Correlation between clinical findings and eosinophil/neutrophil ratio in patients with nasal polyps

Cited by 39 publications

References 37 publications

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

Impact of Allergy and Eosinophils on the Morbidity of Chronic Rhinosinusitis with Nasal Polyps in Northwest China

IL-33 Expression in Chronic Rhinosinusitis with Nasal Polyps and Its Relationship with Clinical Severity

Predictive value of computed tomography in the recurrence of chronic rhinosinusitis with nasal polyps

Contact Info

Product

Resources

About