Correlation between circulating osteopontin level in systemic lupus erythematosus and disease activity and associations between osteopontin polymorphisms and disease susceptibility: A meta-analysis

Lee, Young Ho; Song, Gwan Gyu

doi:10.1177/0961203316655214

Cited by 14 publications

(22 citation statements)

References 25 publications

(42 reference statements)

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“…Our results showed that there was statistical significant increase in mean serum level of OPN in SLE patients compared to control group and the elevation correlated positively with SLEDAI and there were significant increase of OSP level in active SLE patients (19 patients) when compared to inactive SLE patients (11 patients). This in agreement with Lee and Song meta-analysis who did study on 1938 SLE patients revealed a significantly higher circulating OPN level in SLE patients with positive correlation between OPN levels and SLE activity (19). Similarly, other study done on fifty four Chinese found that serum OPN concentrations were significantly higher in systemic lupus erythematosus (SLE) patients with renal impairment and in SLE patients than controls.…”

Section: Discussionsupporting

confidence: 88%

Role of Osteopontin in Systemic Lupus Erythematosus

Maghraby¹,

Refaei²,

Hassan³

et al. 2018

IAM

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Background: Systemic lupus erythematosus (SLE) is a multisystemic disease, caused by a variety of factors, which lead to immunological abnormalities. Osteopontin (OPN) is a pleiotropic protein, important in bone remodeling and immune system signaling. It produced by various cells, including immune cells, and played a key role in regulating T-helper 1/T-helper 2 balances, stimulating B lymphocytes to produce antibodies, regulating macrophages, neutrophils and inducing dendritic cells. Over expression of OPN has been associated with the pathogenesis of immune-mediated diseases. Objectives: To investigate the role of osteopontin in SLE and to assess its relation to disease activity and subclinical atherosclerosis. Subjects and Methods: This cross sectional case control study was conducted on 30 SLE patients fulfilling SLICCA /ACR criteria for SLE classification and 30 subjects sex-and agematched apparently healthy as control group. All patients were assessed for SLE disease activity by the systemic lupus activity Index (SLEDAI). Serum OSP and Doppler ultrasound for carotid artery media thickness (CIMT) were measured in all patients and control. Results: Plasma OPN levels were significantly higher in SLE patients than in control group (P<0.001) and had significant positive correlation with disease activity (r 0,595, P<0.05) and CIMT (r = 0.400, P <0.001), but there was no significant correlation between CIMT and disease activity. Conclusion: serum level of OPN was higher in SLE patients and correlated with disease activity and CIMT, and can be used as a marker of subclinical atherosclerosis.

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Section: Discussionsupporting

confidence: 88%

Role of Osteopontin in Systemic Lupus Erythematosus

Maghraby¹,

Refaei²,

Hassan³

et al. 2018

IAM

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“…Moreover, it showed a trend of positive correlation between OPN levels and the systemic lupus erythematosus disease activity index (SLEDAI) [25]. The relationship between OPN and SLE has been confirmed by genetic studies showing correlations between OPN polymorphisms and development of SLE and suggesting that OPN may participate in a complex network of gene-gene and gene-environment interactions accounting for the SLE clinical heterogeneity.…”

Section: Opn and Autoimmune Diseasesmentioning

confidence: 99%

“…Recently a meta-analysis revealed that the OPN level was significantly higher in SLE patients and particularly in those with renal disease [25]. Moreover, it showed a trend of positive correlation between OPN levels and the systemic lupus erythematosus disease activity index (SLEDAI) [25].…”

Section: Opn and Autoimmune Diseasesmentioning

confidence: 99%

“…Interindividual differences of OPN expression may be also influenced by variations in the promoter region, such as −66T>G (rs28357094) and −156G>GG (rs7687316) SNPs, which may modulate the transcriptional activity of the gene [15–18]. Table 1 summarizes several associations reported between OPN SNPs and autoimmune diseases (http://www.ncbi.nlm.nih.gov/projects/SNP/) [10, 13–16, 19–25]. …”

Section: Introductionmentioning

confidence: 99%

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Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases

Clemente

Raineri

Cappellano

et al. 2016

Journal of Immunology Research

129

110

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Osteopontin (OPN) regulates the immune response at multiple levels. Physiologically, it regulates the host response to infections by driving T helper (Th) polarization and acting on both innate and adaptive immunity; pathologically, it contributes to the development of immune-mediated and inflammatory diseases. In some cases, the mechanisms of these effects have been described, but many aspects of the OPN function remain elusive. This is in part ascribable to the fact that OPN is a complex molecule with several posttranslational modifications and it may act as either an immobilized protein of the extracellular matrix or a soluble cytokine or an intracytoplasmic molecule by binding to a wide variety of molecules including crystals of calcium phosphate, several cell surface receptors, and intracytoplasmic molecules. This review describes the OPN structure, isoforms, and functions and its role in regulating the crosstalk between innate and adaptive immunity in autoimmune diseases.

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“…Increased levels of OPN have been found in SLE patients compared to controls [72], and to correlate with both disease activity [73] and damage accrual [74,75]. Mechanistic implications for a role in SLE pathogenesis includes that overexpression of OPN in lupus prone mice induces B-cell activation and subsequent production of anti-dsDNA antibodies [76,77].…”

Section: Opnmentioning

confidence: 99%

Biomarkers of disease activity and organ damage in systemic lupus erythematosus

Wirestam¹

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Jag tror att när vi går igenom tiden att allt det bästa inte hänt än Håkan Hellström ABSTRACTSystemic lupus erythematosus (SLE) is a systemic inflammatory disease. Clinically, the distinction between ongoing inflammation attributed to SLE, and organ damage due to medication or co-morbidities remains challenging. In addition, SLE is a heterogeneous disease where the various disease phenotypes complicate the search for biomarkers that adequately reflect disease activity and/or signs of increasing organ damage. The aim of the thesis was to investigate and evaluate potential new biomarkers of disease activity and/or organ damage in SLE patients.High mobility group box protein-1 (HMGB1) is a nuclear non-histone protein that can shuttle to the cytoplasm, become secreted extracellularly, and participate in systemic inflammation.Administration of monoclonal anti-HMGB1 antibodies has been reported both to attenuate and intensify disease in animal models of arthritis and lupus. In Paper I of the thesis, circulating anti-HMGB1 was found in 23% of the SLE patients and correlated with disease activity variables. The biological role of these autoantibodies remains to be elucidated.As a consequence of massive circulating levels of cellular debris and immune complexes, SLE patients have insufficient capacity to remove such material via the reticuloendothelial system. Pentraxin 3 (PTX3) may possibly protect against lupus flares due to classical complement activation, opsonization of apoptotic cells, and cytokine induction. In Paper II, circulating PTX3 was found to be inhibited or exhausted by interferon (IFN)-α, a key cytokine of SLE pathogenesis, and serum levels of PTX3 in SLE patients were inversely related to IFN-α levels.Suppressed PTX3 levels may contribute to a vicious circle resulting in impaired waste clearance, autoantigen exposure and autoantibody production, and sustained disease activity.Osteopontin (OPN), a protein known to influence cell signaling and apoptosis, has been proposed as a marker of organ damage in pediatric lupus. In a Swedish cross-sectional study, circulating OPN levels were found to be raised in SLE (Paper III). In patients with recent-onset disease, OPN reflected disease activity, while in established disease, OPN appeared to mirror damage accrual and cardiovascular damage. In Paper IV, OPN was instead analyzed in an international longitudinal multi-center study based on patients with recent-onset SLE and follow-up data. OPN turned out to be a poor predictor of organ damage, but significant associations were observed between OPN and disease activity both at disease onset, as well as over 5 years of follow-up.In conclusion, increased anti-HMGB1 antibody and decreased PTX3 levels could potentially sustain the impaired waste-disposal. Of the molecules analyzed in this thesis, OPN seems to be the best marker of disease activity. Further studies of these proteins may help to better understand SLE pathogenesis and to optimize treatment of patients.

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Correlation between circulating osteopontin level in systemic lupus erythematosus and disease activity and associations between osteopontin polymorphisms and disease susceptibility: A meta-analysis

Cited by 14 publications

References 25 publications

Role of Osteopontin in Systemic Lupus Erythematosus

Role of Osteopontin in Systemic Lupus Erythematosus

Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases

Biomarkers of disease activity and organ damage in systemic lupus erythematosus

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