Correlation between cerebral reorganization and motor recovery after subcortical infarcts

Loubinoux, Isabelle; Carel, Christophe; Pariente, Jérémie; Dechaumont, Sophie; Albucher, Jean‐François; Marqué, P.; Manelfe, C.; Chollet, François

doi:10.1016/j.neuroimage.2003.08.017

Cited by 223 publications

(202 citation statements)

References 59 publications

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“…There is evidence that reorganization in the adult brain can even involve the formation of new neural connections [28] [29]. Therefore, understanding the brain's ability to reorganize itself dynamically can help the scientists understand how human sometimes recover brain functions damaged by injury or disease [30].…”

Section: Discussionmentioning

confidence: 99%

Can Digital Games Be a Way of Improving the Neuroplasticity in Stroke Damage? Can the Adult Brain Grow New Cells or Rewire Itself in Response to a New Experience?

Valentin¹

2017

OJMP

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Exploratory studies developed at several neurosciences laboratories at universities around the world show us through the experience that there is a biological process called neuroplasticity. Because of this oldest concept about the neuronal formation, scientists also thought that if a particular area of the adult brain was damaged, the nerve cells could not form new connections and the functions controlled by this field of the brain would be permanently lost or could not be regenerate. However, studies have overturned this old view, and currently, scientists recognize that the brain continues to reorganize itself by forming new neural connections during the life. This phenomenon is called neuroplasticity that refers to the potential which the brain should be reorganized by creating new neural pathways to adapt, as it needs.

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Section: Discussionmentioning

confidence: 99%

Can Digital Games Be a Way of Improving the Neuroplasticity in Stroke Damage? Can the Adult Brain Grow New Cells or Rewire Itself in Response to a New Experience?

Valentin¹

2017

OJMP

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“…These findings correlated positively with one index of motor recovery, the hand score of the motricity index. 56 Taken together, these neuroimaging studies suggest that activation in ipsilesional motor areas plays an important role in the recovery process. Neurophysiological studies showed that transient disruption of activity in the ipsilesional M1 and dorsal premotor cortex of patients with chronic stroke and good motor recovery caused clear transient deficits in motor performance of the paretic hand.…”

Section: Activity In the Ipsilesional Hemispherementioning

confidence: 91%

“…59,60 The magnitude of contralesional activation appears to decrease in M1 at 3 to 6 months, relative to 1 week after the stroke, 60,32 but the intensity of contralesional M1 activity does not correlate with the degree of recovery. 56 This finding might indicate that contralesional activation is not functionally relevant for recovery, 56 or that it is insufficient to compensate for a marked motor deficit.…”

Section: Activity In the Contralesional Hemispherementioning

confidence: 99%

Noninvasive brain stimulation in stroke rehabilitation

Webster

Celnik

Cohen

2006

NeuroRX

144

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Summary:Stroke is a common disorder that produces a major burden to society, largely through long-lasting motor disability in survivors. Recent studies have broadened our understanding of the processes underlying recovery of motor function after stroke. Bilateral motor regions of the brain experience substantial reorganization after stroke, including changes in the strength of interhemispheric inhibitory interactions. Our understanding of the extent to which different forms of reorganization contribute to behavioral gains in the rehabilitative process, although still limited, has led to the formulation of novel interventional strategies to regain motor function. Transcranial magnetic (TMS) and DC (tDCS) electrical stimulation are noninvasive brain stimulation techniques that modulate cortical excitability in both healthy individuals and stroke patients. These techniques can enhance the effect of training on performance of various motor tasks, including those that mimic activities of daily living. This review looks at the effects of TMS and tDCS on motor cortical function and motor performance in healthy volunteers and in patients with stroke. Both techniques can either enhance or suppress cortical excitability, and may move to the clinical arena as strategies to enhance the beneficial effects of customarily used neurorehabilitative treatments after stroke.

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“…Future studies of passive ankle dorsiflexion will determine if this paradigm can substitute for voluntary movement in subjects who cannot dorsiflex the ankle. Passive movement has shown some potential in several other neuroimaging studies (Loubinoux et al, 2003;Reddy et al, 2002) with significant correlations between dynamic sensorimotor activations for hand function in bilateral inferior BA 40 and continued gains.…”

Section: Locomotor Training-induced Plasticitymentioning

confidence: 99%

Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation

et al. 2004

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The ability to walk independently with the velocity and endurance that permit home and community activities is a highly regarded goal for neurological rehabilitation after stroke. This pilot study explored a functional magnetic resonance imaging (fMRI) activation paradigm for its ability to reflect phases of motor learning over the course of locomotor rehabilitation-mediated functional gains. Ankle dorsiflexion is an important kinematic aspect of the swing and initial stance phase of the gait cycle. The motor control of dorsiflexion depends in part on descending input from primary motor cortex. Thus, an fMRI activation paradigm using voluntary ankle dorsiflexion has face validity for the serial study of walking-related interventions. Healthy control subjects consistently engaged contralateral primary sensorimotor cortex (S1M1), supplementary motor area (SMA), premotor (PM) and cingulate motor (CMA) cortices, and ipsilateral cerebellum. Four adults with chronic hemiparetic stroke evolved practice-induced representational plasticity associated with gains in speed, endurance, motor control, and kinematics for walking. For example, an initial increase in activation within the thoracolumbar muscle representation of S1M1 in these subjects was followed by more focused activity toward the foot representation with additional pulses of training. Contralateral CMA and the secondary sensory area also reflected change with practice and gains. We demonstrate that the supraspinal sensorimotor network for the neural control of walking can be assessed indirectly by ankle dorsiflexion. The ankle paradigm may serve as an ongoing physiological assay of the optimal type, duration, and intensity of rehabilitative gait training.

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Correlation between cerebral reorganization and motor recovery after subcortical infarcts

Cited by 223 publications

References 59 publications

Can Digital Games Be a Way of Improving the Neuroplasticity in Stroke Damage? Can the Adult Brain Grow New Cells or Rewire Itself in Response to a New Experience?

Can Digital Games Be a Way of Improving the Neuroplasticity in Stroke Damage? Can the Adult Brain Grow New Cells or Rewire Itself in Response to a New Experience?

Noninvasive brain stimulation in stroke rehabilitation

Ankle dorsiflexion as an fMRI paradigm to assay motor control for walking during rehabilitation

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