Correlation between CD64 and PCT levels in cerebrospinal fluid and degree of hearing impairment sequelae in neonates with purulent meningitis

Abstract

This study investigated the possible correlation between the degree of hearing impairment caused by neonatal purulent meningitis and the levels of CD64 and PCT in cerebrospinal fluid of patients, and assessed the prognostic value of such levels. We recorded data from 156 cases of neonatal purulent meningitis retrospectively. All the patients received brainstem response audiometry, and cerebrospinal fluid samples were collected within the first day after admission through lumbar puncture. Flow cytometry was used to detect CD64 levels and enzyme-linked fluorescent assay was used to detect PCT levels. The children with hearing impairment were followed up for 1 year and brainstem response audiometry was performed again in them. We found that 43.59% of the children showed different degrees of hearing impairment, and 55% of them did not fully recover. The levels of PCT and CD64 in cerebrospinal fluid of children with hearing impairment were significantly higher than those of children with normal hearing (P<0.01). The levels of PCT and CD64 in mild, moderate and severe hearing impaired children increased gradually with higher degrees of impairment, and the differences between groups were significant (P<0.01). During the follow-up, it was found that the levels of PCT and CD64 in children correlated well with the degree of hearing recovery, and the differences between groups were significant (P<0.01). In our study, approximately 1/4 children with purulent meningitis showed long-term hearing impairment. Based on our analyses, the levels of CD64 and PCT in cerebrospinal fluid can be used to predict the degree and long-term prognosis of hearing impairment caused by purulent meningitis in children.

Analysis of bacterial spectrum, activin A, and CD64 in chronic obstructive pulmonary disease patients complicated with pulmonary infections

“…CD64 is usually expressed in low quantities in neutrophils, but a significant rise in expression occurs with the stimulation of pathological factors or inflammatory cytokines. Therefore, the neutrophil CD64 index is used as a diagnostic and prognostic biomarker in multiple diseases like systemic lupus erythematosus, neonatal sepsis, bacterial peritonitis, and inflammatory bowel diseases[ 4 - 6 ]. Previous studies found that CD64 is also an important diagnostic and prognostic biomarker in COPD patients[ 8 , 18 ].…”

“…Following infection, however, CD64 Levels rise due to the direct stimulation of pathogenic microorganisms or the indirect stimulation of inflammatory cytokines. Therefore, the neutrophil CD64 index can act as an early diagnostic marker for infection[ 4 - 6 ]. Moreover, multiple reports correlated the CD64 index with the severity associated with COPD and bacterial infections.…”

Blood-brain barrier damage as a predictor of outcome in patients with purulent meningitis

“…Several serum and CSF parameters are analyzed in predicting the outcome of the disease. Soluble urokinase receptor values in CSF [33], PCT [34], CRP [35], matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 [36], and CD64 [37], correspond to the severity and outcome of purulent meningitis. It is a well-known fact that concentrations of albumins and the albumin coefficient are gold standard measures of BBB function [26,27,[38][39][40].…”

Ameliorative effects of ceftriaxone sodium combined with dexamethasone on infantile purulent meningitis and associated effects on brain‑derived neurotrophic factor levels

“…, Streptococcus pneumoniae and Haemophilus influenzae ( 4 ). Since acute infant PM is severe and harmful, missing the optimal treatment time directly endangers the life of the patients ( 5 ); if not treated on time, the mortality rate associated with this disease can reach 50-70% ( 6 ).…”