Correlation between caries activity and salivary microbiota in preschool children

Lin, Xiuyan; Wang, Yuan; Ma, Zhe; Xie, Meng; Liu, Zhuo; Cheng, Jinghui; Tian, Yuzhao; Hong, Shi

doi:10.3389/fcimb.2023.1141474

Cited by 6 publications

(4 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study ,there were no statistical differences in alpha diversity observed between males and females across data sets using standard estimates, including standard Shannon entropy and Chao1 diversity approaches, which has been reported in other studies, including a study conducted in the neighbouring country of Qatar [ 23 , 24 ]. However, the high versus low dental caries groups had statistically significant differences in alpha diversity using the same approaches.…”

Section: Discussionsupporting

confidence: 76%

“…The Selenomonadaceae family observation is consistent with an over-representation of a severe caries cohort in a 2020 Indian study conducted by Kalpana et al [ 32 ]. In addition a report by Lin et al identified the Selenomonadaceae family to be a potential biomarker for high dental caries subjects and exhibited a positive correlation with DMFT [ 24 ]. Moreover, Tang et al showed that the anaerobic glycolytic pathway was significantly upregulated in the high dental caries group in unison with upregulation of these bacterial families, which leads to elevated acid production, thereby overwhelming the healthy microbiome capacity for buffering [ 14 , 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral microbiota analyses of paediatric Saudi population reveals signatures of dental caries

Alyousef,

Piotrowski,

Alonaizan

et al. 2023

BMC Oral Health

View full text Add to dashboard Cite

Background Oral microbiome sequencing has revealed key links between microbiome dysfunction and dental caries. However, these efforts have largely focused on Western populations, with few studies on the Middle Eastern communities. The current study aimed to identify the composition and abundance of the oral microbiota in saliva samples of children with different caries levels using machine learning approaches. Methods Oral microbiota composition and abundance were identified in 250 Saudi participants with high dental caries and 150 with low dental caries using 16 S rRNA sequencing on a NextSeq 2000 SP flow cell (Illumina, CA) using 250 bp paired-end reads, and attempted to build a classifier using random forest models to assist in the early detection of caries. Results The ADONIS test results indicate that there was no significant association between sex and Bray-Curtis dissimilarity (p ~ 0.93), but there was a significant association with dental caries status (p ~ 0.001). Using an alpha level of 0.05, five differentially abundant operational taxonomic units (OTUs) were identified between males and females as the main effect along with four differentially abundant OTUs between high and low dental caries. The mean metrics for the optimal hyperparameter combination using the model with only differentially abundant OTUs were: Accuracy (0.701); Matthew’s correlation coefficient (0.0509); AUC (0.517) and F1 score (0.821) while the mean metrics for random forest model using all OTUs were:0.675; 0.054; 0.611 and 0.796 respectively. Conclusion The assessment of oral microbiota samples in a representative Saudi Arabian population for high and low metrics of dental caries yields signatures of abundances and diversity.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Oral microbiota analyses of paediatric Saudi population reveals signatures of dental caries

Alyousef,

Piotrowski,

Alonaizan

et al. 2023

BMC Oral Health

View full text Add to dashboard Cite

show abstract

“…In agreement with the current study, Pratyusha et al [ 22 ] conducted a comparative cross-sectional study on association of serum VD and salivary Ca level in 3-11-year-old schoolchildren with dental caries, indicating that VD deficiency and lower salivary Ca levels may be the potential risk factors for the occurrence of dental caries. The composition of salivary microbial community was highly correlated with Ca, and the cariogenic microorganisms present in the oral cavity play a key role in the occurrence and development of childhood caries, and the formed biofilm can metabolize carbohydrates to produce organic acids, resulting in local pH decline and demineralization of dental hard tissues [ 23 ]. Differently, in this study, we assessed the dietary Ca intake level, which may have specific underlying mechanisms to explain the relationship of deficient dietary Ca intake and high odds of dental caries.…”

Section: Discussionmentioning

confidence: 99%

Combined effect of dietary calcium consumption and physical activity on dental caries in children and adolescents: a study of the NHANES database

Zhang,

Bai,

Jin

et al. 2024

BMC Oral Health

View full text Add to dashboard Cite

Background Calcium (Ca) is a nutritional factor that associated with dental caries. A recent study showed that in the case of adequate Ca intake, a higher level of physical activity may contribute to bone mass accumulation. However, the combined effect between Ca intake and physical activity on caries experience is unclear. Herein, we aimed to explore the above combined effect on dental caries in children and adolescents. Methods Data of 5,917 children and adolescents were extracted from the National Health and Nutrition Examination Surveys (NHANES) database in 2015–2020 in this cross-sectional study. The NHANES assessed the dietary Ca intake through the 24-hour dietary recalls, and the physical activity level was self-reported using the questionnaires. Also, the dental caries was diagnosed according to the Decayed, Missing and Filled Teeth/Surfaces (DMFT/S) index. Weighted univariate and multivariate logistic regression analyses were utilized to screen the covariates and to investigate the associations of dietary Ca intake and physical activity with dental caries, respectively, and assess the combined effect between dietary Ca intake and physical activity on dental caries. The evaluation indexes were odd ratios (ORs) and 95% confidence intervals (CIs). Subgroup analyses of age, obesity, and total sugar intake were also performed. Results Among the eligible participants, 2,687 had caries experience. After adjusting for the covariates, we found that children and adolescents who not reach the recommendation level of Ca intake combined with physical activity less than 7 time in 1 week seemed to have higher odds of dental caries [OR = 1.77, 95%CI: (1.38–2.27)], compared with those who reached the standards. In addition, this potential combined effect was also found in age < 12 years old [OR = 1.62, 95%CI: (1.23–2.14)], non-obesity [OR = 1.88, 95%CI: (1.49–2.35)], and total sugar intake (all P < 0.05) subgroups. Conclusions Ca intake and physical activity had a potential combined effect on dental caries in children and adolescents, but the causal relationships between them needed further clarification.

show abstract

“…In 2019, the National Health Commission of China implemented the Healthy Mouth Action Program (2019–2025) to increase oral health awareness and promote oral health–enhancing behavior in the public. Preventing and treating dental caries have long been a subject of social research, and many studies have focused on children[ 14 ]. In 2021, the National Health Commission implemented the Action Plan for Improvement of Maternal and Infant Safety (2021–2025)[ 15 ], which emphasizes hygiene and maternal and infant safety.…”

Section: Discussionmentioning

confidence: 99%

Effects of personalized oral hygiene management on oral health status of pregnant women

Men,

Du,

2024

World J Clin Cases

View full text Add to dashboard Cite

BACKGROUND The Cariostat caries activity test (CAT) was used to evaluate the effectiveness of personalized oral hygiene management combining oral health education and professional mechanical tooth cleaning on the oral health status of pregnant women. AIM To investigate whether personalized oral hygiene management enhances the oral health status of pregnant women. METHODS A total of 114 pregnant women who were examined at Dalian Women’s and Children’s Medical Center were divided into four groups: High-risk experimental group (n = 29; CAT score ≥ 2; received personalized oral hygiene management training), low-risk experimental group (n = 29; CAT score ≤ 1; received oral health education), high-risk control group (n = 28; CAT score ≥ 2), and low-risk control group (n = 28; CAT score ≤ 1). No hygiene intervention was provided to control groups. CAT scores at different times were compared using independent samples t -test and least significant difference t -test. RESULTS No significant difference in baseline CAT scores was observed between the experimental and control groups, either in the high-risk or low-risk groups. CAT scores were reduced significantly after 3 (1.74 ± 0.47 vs 2.50 ± 0.38, P < 0.0001) and 6 months (0.53 ± 0.50 vs 2.45 ± 0.42, P < 0.0001) of personalized oral hygiene management intervention but not after oral health education alone (0.43 ± 0.39 vs 0.46 ± 0.33, P > 0.05 and 0.45 ± 0.36 vs 0.57 ± 0.32, P > 0.05, respectively). Within groups, the decrease in CAT scores was significant (2.43 ± 0.44 vs 1.74 ± 0.47 vs 0.53 ± 0.50, P < 0.0001) for only the high-risk experimental group. CONCLUSION Personalized oral hygiene management is effective in improving the oral health of pregnant women and can improve pregnancy outcomes and the oral health of the general population.

show abstract

Correlation between caries activity and salivary microbiota in preschool children

Cited by 6 publications

References 65 publications

Oral microbiota analyses of paediatric Saudi population reveals signatures of dental caries

Oral microbiota analyses of paediatric Saudi population reveals signatures of dental caries

Combined effect of dietary calcium consumption and physical activity on dental caries in children and adolescents: a study of the NHANES database

Effects of personalized oral hygiene management on oral health status of pregnant women

Contact Info

Product

Resources

About