Introduction: the giant cell tumor of bone is a rare entity before the third decade of life, as well as the development of lung metastasis. Aggressive and large lesions make treatment difficult. Case presentation: it is the case of a 17-year-old female with a giant cell tumor of bone in the right proximal humerus showing cortical destruction and joint and scapular invasion, and also soft tissue involvement. The patient was treated with a Malawer type VI B resection that progressed without complications; a good function was obtained in the elbow and excellent in the wrist and hand. The patient developed a single lung metastasis treated with metastatectomy by minithoracotomy, confirming diagnosis. Conclusions: giant cell tumor of bone is a diagnostic and therapeutic challenge, especially when it presents before its usual age. The treatment alternative depends on the location and size of the lesion. Lung metastasis although rare, must be continuously ruled out. Early diagnosis and timely treatment have a positive impact on the patient.