Correlation between Blood Prostaglandins and Blood Pressure in Chronic Renal Failure

Abstract

Plasma prostaglandins (PGs; PGE₂, PGF_2α, 6-keto-PGF_1α and TXB₂) and plasma renin activity (PRA) were measured in 94 end-stage renal disease (ESRD) patients including 15 undialyzed, 74 maintenance-hemodialyzed and 5 anephric patients, and in 27 healthy controls. In the healthy controls, 6-keto-PGF_1α inversely correlated with age, while TXB₂ and the TXB₂/6-keto-PGF_1α ratio correlated with age. In the ESRD patients, 6-keto-PGF_1α showed a tendency to decrease with age, and the TXB₂/6-keto-PGF_lα ratio significantly correlated with age. The undialyzed group showed significantly higher blood pressure and TXB₂ but significantly lower 6-keto-PGF_1α compared to the other groups. In the dialyzed group, PGE₂ and 6-keto-PGF_1α tended to be lower and TXB₂ higher compared to the healthy control group. In the dialyzed group, 6-keto-PGF_1α correlated inversely with blood pressure independently from PRA. As for PGF_2α, it was higher in the undialyzed, dialyzed and anephric groups than in the healthy control group. These results suggested that PGs were involved in blood pressure abnormalities, and that PGI₂ played an important role in controlling blood pressure in ESRD patients as one of the depressor factors.

Haemodynamic effects of magnesium lithospermate B in rats with renal failure

“…In addition, it has been speculated that a deficiency of renal prostaglandin E2 production is related to hypertension associated with chronic renal failure (Yoshida et al, 1986;Machida et al, 1988;Ruilope et al, 1982). Progressive hypertension is also associated with increased renal and cerebral vascular resistance, and this form of hypertension is one of the main underlying risk factors for chronic renal failure (Arendshorst and Beierwaltes, 1979;Kishimoto et al, 1987).…”

Correlation between Blood Prostaglandins, Plasma Lipids and Atherosclerosis in Dialyzed Patients

“…Several rea sons may account for this. One is that the pattern of blood PGs in nondialyzed patients with end-stage renal failure, who were non diabetic, was similar to that in diabetic pa tients [1], In addition, the period of dialysis therapy was significantly longer in nondia betic patients compared to diabetic patients. That is, in hemodialysis by extracorporeal circulation, the bioincompatibility of medi cal polymers which compose the extracor poreal circulation causes complement acti vation and stimulates the platelets, increas ing the production of TXA2 [30,31], and these physiologically active substances cause vascular damage [32,33].…”

“…PGs were radioimmunoassayed according to the method previously described [1). The plasma samples were extracted with petro leum ether to remove neutral lipids, and PGs were extracted with ethyl acetate at pH 3.5.…”

“…We have reported in 1987 that a correla tion was found between blood prostaglan dins (PGs) and blood pressure in patients with end-stage renal failure, and that PGI2 and thromboxane A2 (TXA2), in addition to body fluid and the renin-angiotensin system, played an important role in the control of blood pressure [1], Other investigations, made both in vitro and in vivo, have indi cated that blood PGs and the degree of ath erosclerosis correlated with each other [2][3][4][5][6][7][8][9]. Furthermore, it has also been pointed out that the degree of atherosclerosis showed a significant correlation with arterial com pliance or arterial pulse wave velocity (PWV) [10][11][12][13][14][15][16][17], We studied whether there is any correlation between blood PGs, plasma lipids and PWV of the aorta in 40 mainte nance hemodialyzed patients.…”

Ο Ρόλος Των Αγγειοδραστικών Παραγώγων Του Αραχιδονικού Οξέος Στη Λιπιδική Υπεροξείδωση Των Ουραιμικών Ασθενών

“…Σε άτομα με καρδιοπνευμονική αναστόμωση 266 28. Στους ασθενείς με χρόνια νεφρική ανεπάρκεια (ΧΝΑ) προ τελικού σταδίου 267 29. Στους ασθενείς με ΧΝΑ τελικού σταδίου, σε αιμοκάθαρση ή περιτοναϊκή κάθαρση 268 30.…”