Correlation between Biochemical and Anti-Oxidative status in Rheumatoid Arthritis Patients Update from Lahore, Pakistan

Arsalan, Hafiz Muhammad; Altaf, Maria; Amin, Zeemal Seemab; Khan, Muhammad Aslam; Shahzadi, Anum; Mudasser, Hina; Maqsood, Iqra; Gulshan, Nazia; Naseem, Saira

doi:10.17582/journal.pujz/2019.34.2.159.164

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…17 Another research on AS patients revealed an increase in SOD and glutathione (GSH) levels in patients with metabolic syndrome. 18 The finding of these studies regarding SOD levels is not in agreement with the current results, but fluctuations in the levels of SOD have also been observed in rheumatic diseases, based upon the differences in the phase of the disease. Generally, the rise in SOD levels is attributed to the initial time period of the active phase.…”

Section: Discussioncontrasting

confidence: 64%

“…This contradiction in the levels of antioxidants in rheumatic diseases has been cited in other studies as well, like a study in Pakistani population that showed rise in SOD levels in RA patients along with rise in MDA levels. 18 Among the category of enzymatic antioxidants, SOD, GPx and CAT have been the subject of extensive research for evaluating OS. The result of Mahdi et al was in congruence with the current results where the levels of SOD declined and those of MDA were significantly raised in RA group compared to the controls.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of oxidative stress, lipid peroxidation and inflammatory markers between rheumatoid arthritis and ankylosing spondylitis patients

Sumbal Khan,

Dr M Javad Yousaf,

Dr Amir Rashid

et al. 2024

J Pak Med Assoc

View full text Add to dashboard Cite

Objective: To measure the levels of superoxide dismutase and malondialdehyde along with erythrocyte sedimentation rate and C-reactive protein in patients of rheumatoid arthritis and ankylosing spondylitis. Method: The comparative, cross-sectional study was conducted from February 2 to December 30, 2022, at the Centre for Research in Experimental and Applied Medicine laboratory of the Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, Pakistan, in collaboration with the Department of Rheumatology, Pak Emirates Military Hospital, Rawalpindi. The sample comprised healthy controls in group 1, patients of rheumatoid arthritis in group 2 and patients of ankylosing spondylitis in group 3. Blood samples were assessed for levels of superoxide dismutase, malondialdehyde, erythrocyte sedimentation rate and C-reactive protein. Data was analysed using SPSS 25. Results: Of the 180 subjects, 60(33.3%) were in group 1; 32(53.3%) females and 28(46.7%) males with mean age 34.9±6.4 years. There were 60(33.3%) patients in group 2; 35(58.3%) females and 25(41.7%) males with mean age 46.0±11.1 years. There were 60(33.3%) patients in group 3, and all 60(100%) were males with mean age 35.9±6.9 years. Superoxide dismutase level was significantly low and malondialdehyde level was significantly high in groups 2 and 3 compared to group 1 (p<0.05). Erythrocyte sedimentation rate was the highest in group 2, followed by group 3 (p<0.05). C-reactive protein levels were the highest in group 2 and the lowest in group 3 (p<0.05). A significantly negative correlation (p<0.001) was found between superoxide dismutase and malondialdehyde. Conclusion: Oxidative stress played a pivotal role in chronic inflammatory rheumatic diseases, like rheumatoid arthritis and ankylosing spondylitis. Key Words: Rheumatoid arthritis, Ankylosing spondylitis, Superoxide dismutase, Malondialdehyde.

show abstract

Section: Discussioncontrasting

confidence: 64%

Section: Discussionmentioning

confidence: 99%