Correlation between Bhalla score and spirometry in children and adolescents with Cystic Fibrosis

Ibiapina, Cássio da Cunha; Alvim, Cristina Gonçalves; Camargos, Paulo Augusto Moreira; Figueiredo, Reginaldo; Pedrosa, Jesiana Ferreira

doi:10.1590/1806-9282.60.03.009

Cited by 12 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The literature clearly outlines the high correlation between spirometry and lung structure markers obtained with radiography and HRCT, especially in severe lung disease. [36][37][38][39] However, the use of lung ultrasound can enable a better understanding of the intrinsic association between function and structure, considering that, in our findings, we observed a significant correlation between the results of lung ultrasound, modified Bhalla score, spirometry, S pO 2 , and body mass index.…”

Section: Discussionmentioning

confidence: 79%

The Use of Ultrasound as a Tool to Evaluate Pulmonary Disease in Cystic Fibrosis

Peixoto

Marson

Dertkigil³

et al. 2019

Respir Care

View full text Add to dashboard Cite

BACKGROUND: Lung ultrasound is an examination that allows the assessment of pulmonary involvement by analyzing artifacts. Our primary aim was to correlate our lung ultrasound findings with pulmonary function and the modified Bhalla score in patients with cystic fibrosis. METHODS: Subjects with cystic fibrosis were evaluated based on the results of lung ultrasound, pulmonary function exams (ie, spirometry before and after the use of a bronchodilator and S pO 2), and the modified Bhalla score. The partial correlation set by age between lung ultrasound, pulmonary function, and modified Bhalla score was carried out. Lung ultrasound was graded according to a new score, ranging from 0 to 36, with a higher score being associated with a greater degree of involvement. We performed Bland-Altman and linear regression analysis to identify bias between lung ultrasound and modified Bhalla score. Alpha ‫؍‬ 0.05. RESULTS: 18 subjects with cystic fibrosis were included. In partial correlation controlled by age, we observed significant ultrasound score values with weight (partial correlation ‫؍‬ ؊0.579), body mass index (partial correlation ‫؍‬ ؊0.609), S pO 2 (partial correlation ‫؍‬ ؊0.728), FVC% (pre-bronchodilator: partial correlation ‫؍‬ ؊0.538; post-bronchodilator: partial correlation ‫؍‬ ؊0.560), FEV 1 % (pre-bronchodilator: partial correlation ‫؍‬ ؊0.536; post-bronchodilator: partial correlation ‫؍‬ ؊0.546), and modified Bhalla score (partial correlation ‫؍‬ 0.607). We did not identify bias between lung ultrasound and modified Bhalla score measured by z-score. CONCLUSIONS: Lung ultrasound seems to be effective and corroborates with high-resolution computed tomography when evaluated by the modified Bhalla score. At the same time, lung ultrasound had significant correlation with pulmonary function and nutritional status.

show abstract

Section: Discussionmentioning

confidence: 79%

The Use of Ultrasound as a Tool to Evaluate Pulmonary Disease in Cystic Fibrosis

Peixoto

Marson

Dertkigil³

et al. 2019

Respir Care

View full text Add to dashboard Cite

show abstract

“…These include the Brody II score [134] and the CF-CT score [135], while one of the older original scoring tools, the Bhalla score, for bronchiectasis is still widely used in modified versions [107]. The Bhalla scoring system is an objective measure incorporating all aspects of CF structural abnormalities and has been validated and correlates with spirometry [136], clinical condition [127,137], and has some correlation with health related quality of life [138], however, there is little correlation between these scores and other biomarkers of inflammation [106].…”

Section: Radiological Methods To Predict Prognosismentioning

confidence: 99%

Factors Affecting Prognosis and Prediction of Outcome in Cystic Fibrosis Lung Disease

McCarthy¹,

O’Carroll²,

Franciosi³

et al. 2015

Cystic Fibrosis in the Light of New Research

View full text Add to dashboard Cite

Cystic fibrosis CF is a multisystem disorder with a significantly shortened life expectancy with the major cause of mortality related to lung disease. Inflammation is seen in the CF airways from a very early age and contributes significantly to symptoms and disease progression. "s the condition worsens over time, lung function declines, usually measured by Forced Expiratory Volume in second FEV % predicted, and extra-pulmonary complications often manifest. While the life expectancy in CF is still short, the median age of death and predicted survival age are continually increasing. Therapeutic interventions for CF have improved significantly in the last years and now there are targeted therapies towards specific elements in CF that may impact upon exacerbation frequency, symptoms, and eventually mortality due to lung disease.

show abstract

“…Results were classified as follows: "excellent" when between 21 and 25 points, "good" when between 16 and 20 points, "mild" between 11 and 15 points, "moderate" between 6 and 10 points, and "serious" between 0 and 5 points. 32 Pulmonary function tests were performed according to the American Thoracic Society guidelines, in all patients 6 years of age and older, using a Jaeger Masterlab Spirometer (Erich Jaeger, Wurzburg, Germany). 33 Three acceptable flow-volume maneuvers have been obtained before and 15 minutes after applying 400 mg inhaled salbutamol (metered-dose inhaler).…”

Section: Clinical Evaluation and Imaging Analysismentioning

confidence: 99%

Comprehensive assessment of respiratory complications in patients with common variable immunodeficiency

Moazzami

Nasrabadi

Abolhassani

et al. 2020

Annals of Allergy, Asthma & Immunology

View full text Add to dashboard Cite

Background: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by recurrent upper and lower respiratory tract infections and some noninfectious clinical complications.Objective: To provide a detailed evaluation of respiratory presentations and complications in a cohort of Iranian patients with CVID. Methods: A retrospective cohort study was conducted on 245 CVID patients who were recorded in the Iranian primary immunodeficiency disorders registry network. Respiratory manifestations were evaluated by reviewing clinical hospital records, immunologic findings, pulmonary function tests (PFT), and highresolution computed tomography (HRCT) scans. Results: Most of the patients (n ¼ 208, 85.2%) had experienced at least 1 episode of acute respiratory manifestation, and pneumonia was observed in 31.6 % (n ¼ 77) of cases as a first disease manifestation. During the follow-up, pneumonia, sinusitis, and otitis media were documented in 166 (68.6%), 125 (51.2%), and 103 (42.6%) cases, respectively. Abnormal PFT measurements were documented in 53.8% of patients. Among these patients, 21.5% showed restrictive changes, whereas 18.4% of patients showed an obstructive pattern. Bronchiectasis was the most frequent radiological finding, confirmed in 27.2% of patients. Patients with bronchiectasis were older at the time of immunodeficiency diagnosis (P < .001) and had longer diagnosis delay (P < .001) when compared with patients without bronchiectasis. Conclusion:This study highlights the importance of monitoring the respiratory tract system even in asymptomatic patients. Pulmonary function tests and CT scans are the most commonly used techniques aiming to identify these patients early, aiming to reduce the rate of long-term respiratory complications.

show abstract

Correlation between Bhalla score and spirometry in children and adolescents with Cystic Fibrosis

Cited by 12 publications

References 20 publications

The Use of Ultrasound as a Tool to Evaluate Pulmonary Disease in Cystic Fibrosis

The Use of Ultrasound as a Tool to Evaluate Pulmonary Disease in Cystic Fibrosis

Factors Affecting Prognosis and Prediction of Outcome in Cystic Fibrosis Lung Disease

Comprehensive assessment of respiratory complications in patients with common variable immunodeficiency

Contact Info

Product

Resources

About