Correlation Between Atherosclerosis and Periodontal Putative Pathogenic Bacterial Infections in Coronary and Internal Mammary Arteries

Pucar, Ana; Milašin, Jelena; Lekovic, Vojislav; Vukadinovic, Miroslav; Ristić, Mirjana; Putnik, Svetozar; Kenney, E. Barrie

doi:10.1902/jop.2007.060062

Cited by 135 publications

(130 citation statements)

References 37 publications

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“…Other recent studies have suggested that S. mutans migrates to cardiovascular endothelial tissue [24] and binds to extracellular matrix molecules and fibrinogen [25]. Moreover, DNA from periodontal pathogens was highly prevalent in coronary artery atherosclerosis samples taken from patients with coronary artery disease [26]. These findings support the view that infection with oral bacterial species could be a risk factor for coronary heart disease.…”

Section: Discussionsupporting

confidence: 75%

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

Hanindriyo

Yoshihara²,

Hirotomi³

et al. 2013

OJST

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Periodontal disease is recognized as a risk factor for cardiovascular disease (CVD). Some studies have suggested that serum lipids might play a role in the association between periodontal disease and CVD. However, this hypothesis remains unproven. Present study evaluated the association between periodontal disease and CVD-related parameters including electrocardiographic (ECG) parameters and serum lipid levels in the elderly. This study was a prospective cohort study. A total of 107 subjects (57 males and 50 females) from Niigata City's community-dwelling elderly (all aged 75 years old) who possessed at least 20 teeth and did not exhibit ECG abnormalities at the baseline underwent annual examinations for 5 years. Logistic regression analysis was used to assess the relationship between periodontal condition and the presence of ECG abnormalities, after adjusting for confounding factors including serum lipid levels. Logistic regression analysis showed that the subjects who exhibited a poor periodontal condition at the baseline had a 2.97 times greater risk of suffering from ECG abnormalities than the subjects who displayed a good periodontal condition at the baseline (p = 0.019). Furthermore, the subjects who displayed a poor periodontal condition and an unfavorable serum lipid profile at the baseline showed a significantly higher frequency of ECG abnormalities (63.6%) than those who exhibited a healthy periodontal condition and a favorable serum lipid profile (21.6%, p = 0.008) as well as those who displayed a healthy periodontal condition and an unfavorable serum lipid profile (21.4%, p = 0.010). As a conclusion, periodontal condition could be a marker of CVD, even in the healthy elderly.

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Section: Discussionsupporting

confidence: 75%

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

Hanindriyo

Yoshihara²,

Hirotomi³

et al. 2013

OJST

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show abstract

“…These findings however are relatively new and more research is needed to investigate their contribution to periodontitis and systemic diseases [95].…”

Section: Periodontal Bacteriamentioning

confidence: 99%

Alzheimer's Disease and Peripheral Infections: The Possible Contribution from Periodontal Infections, Model and Hypothesis

Kamer¹,

Dasanayake²,

Craig³

et al. 2008

JAD

151

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Abstract. Alzheimer's disease (AD) affects approximately 4.5 million people in the U.S. and this number will increase as the population ages and the life-span increases. Therefore, of paramount importance is identifying mechanisms and factors that affect the risk of developing AD. The etiology and pathogenic mechanisms for AD have not been defined, although inflammation within the brain is thought to play a role. Consistent with this hypothesis, studies suggest that peripheral infections contribute to the inflammatory state of the central nervous system. Periodontitis is a prevalent, persistent peripheral infection associated with gram negative, anaerobic bacteria that are capable of exhibiting localized and systemic infections in the host. This review offers a hypothetical link between periodontitis and AD and will present possible mechanistic links between periodontitis related inflammation and AD. It will review the pathogenesis of periodontitis and the mechanisms by which periodontal infections may affect the onset and progression of AD. Since periodontitis is a treatable condition, it may be a readily modifiable risk factor for AD.

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“…Usando méto-dos de biología molecular (38), recientemente se identificó una alta prevalencia (60%) de ADN de patóge-nos periodontales dentro de las arterias coronarias con aterosclerosis pero no en las paredes de los vasos mamarios, sugiriendo un papel directo de estos gér-menes en el desarrollo de la aterosclerosis. Además, la periodontitis también modula la estructura del HDL y promueve un perfil lipídico proaterogénico (39).…”

Section: El Amiloide a Sérico Y Su Relación Con Enfermedad Periodontalunclassified

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

Romero-Sánchez

Uribe-Rivera

Velandia-Quintero

et al. 2013

Avances en Periodoncia

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RESUMENLa respuesta de fase aguda es la reacción inflamatoria inmediata del huésped que contrarresta desafíos como lesión de los tejidos, infección y trauma. Los reactantes de fase aguda que han recibido mayor atención son: proteína C reactiva (PCR), componente sérico P, proteína amiloide sérica (AAS) y alfa 1 ácido glicoproteína. Se ha establecido en décadas pasadas que las proteínas de fase aguda no solamente aparecen en procesos de enfermedades severas y agudas si no también en condiciones crónicas. El AAS es el principal componente de las placas amiloideas secundarias depositadas en los órga-nos principales como consecuencia de la enfermedad inflamatoria crónica. La familia de la AAS contiene un número de diferentes apolipoproteínas expresadas, las cuales son sintetizadas principalmente por el hígado. El aumento de AAS es considerado un marcador sistémico de enfermedades inflamatorias agudas y enfermedades crónicas que afecta la composición y función de lipoproteínas de alta densidad (HDL). Se ha demostrado que la intervención terapéutica en la periodontitis disminuye la inflamación y reduce el AAS significativamente y por consiguiente puede reducir el riesgo de enfermedad cardiovascular (ECV). Además es posible que pacientes con periodontitis, que presentan un aumento de la PCR y el AAS, representen un subgrupo específico en términos de riesgo para la aterosclerosis y enfermedad cardiovascular en comparación a los pacientes con periodontitis cuyos niveles plasmáticos de AAS son normales, estableciendo así una relación directa entre la enfermedad periodontal y los niveles de AAS.

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Correlation Between Atherosclerosis and Periodontal Putative Pathogenic Bacterial Infections in Coronary and Internal Mammary Arteries

Cited by 135 publications

References 37 publications

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

The relationship among periodontal condition, serum lipid, and electrocardiographic abnormalities in the elderly: A prospective cohort study

Alzheimer's Disease and Peripheral Infections: The Possible Contribution from Periodontal Infections, Model and Hypothesis

Proteína amiloide A sérica como marcador de inflamación sistémica en pacientes con enfermedad periodontal

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