Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function

Gül, Cuma Bülent; Yıldız, Abdülmecit; Kahvecioğlu, Serdar; Asiltas, Burak; Yildirim, Fatih; Ermurat, Selime; Sağ, Saim; Oruç, Ayşegül; Güllülü, Sümeyye; Güllülü, Mustafa

doi:10.1007/s11255-015-1022-0

Cited by 5 publications

(2 citation statements)

References 43 publications

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“…NLR has also been associated with arterial stiffness and high coronary calcium score in several previous studies ( 48 ). Early detection of abnormal NLR levels may be helpful for detecting increased arterial stiffness in patients with coronary heart disease, type 1 and 2 diabetes mellitus, osteoporosis, and polycystic kidney disease (Table 2 ) ( 19 , 44 , 66 , 67 , 69 , 75 ).…”

Section: Wbcs and Arterial Stiffnessmentioning

confidence: 99%

Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

Malainer²,

et al. 2017

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Arterial stiffness predicts an increased risk of cardiovascular events. Inflammation plays a major role in large arteries stiffening, related to atherosclerosis, arteriosclerosis, endothelial dysfunction, smooth muscle cell migration, vascular calcification, increased activity of metalloproteinases, extracellular matrix degradation, oxidative stress, elastolysis, and degradation of collagen. The present paper reviews main mechanisms explaining the crosstalk between inflammation and arterial stiffness and the most common inflammatory markers associated with increased arterial stiffness, considering the most recent clinical and experimental studies. Diverse studies revealed significant correlations between the severity of arterial stiffness and inflammatory markers, such as white blood cell count, neutrophil/lymphocyte ratio, adhesion molecules, fibrinogen, C-reactive protein, cytokines, microRNAs, and cyclooxygenase-2, in patients with a broad variety of diseases, such as metabolic syndrome, diabetes, coronary heart disease, peripheral arterial disease, malignant and rheumatic disorders, polycystic kidney disease, renal transplant, familial Mediterranean fever, and oral infections, and in women with preeclampsia or after menopause. There is strong evidence that inflammation plays an important and, at least, partly reversible role in the development of arterial stiffness, and inflammatory markers may be useful additional tools in the assessment of the cardiovascular risk in clinical practice. Combined assessment of arterial stiffness and inflammatory markers may improve non-invasive assessment of cardiovascular risk, enabling selection of high-risk patients for prophylactic treatment or more regular medical examination. Development of future destiffening therapies may target pro-inflammatory mechanisms.

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Section: Wbcs and Arterial Stiffnessmentioning

confidence: 99%

Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

Malainer²,

et al. 2017

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“…The neutrophil–lymphocyte ratio (NLR) is a biomarker that reflects the inflammation status of the human body [10] as well as the balance between activation and regulatory factors of inflammation [11]. Several studies have found that NLR is associated with malignant tumors [12], coronary artery disease [13], atherosclerosis [14], heart failure [15], acute pancreatitis [16], diabetes [17], obesity and dyslipidemia [18], hypertension [19], metabolic syndrome (MetS) and endothelial dysfunction [20], osteoporosis [21], and polycystic kidney disease [22,23]. Researchers have increasingly realized the importance of NLR in the progression of ACS.…”

Section: Introductionmentioning

confidence: 99%

Association between neutrophil–lymphocyte ratio and arterial stiffness in patients with acute coronary syndrome

Chen

Huang

et al. 2019

Bioscience Reports

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The aim of the present study was to assess the association between neutrophil–lymphocyte ratio (NLR) and arterial stiffness and provide a predictive index for diagnosing atherosclerosis in patients with acute coronary syndrome (ACS). We enrolled patients with ACST who were confirmed by coronary angiography. Data were collected by questionnaire and blood indexes. Brachial-ankle pulse wave velocity (baPWV) was measured using BP-203RPE III network arteriosclerosis detection equipment. Correlation analysis of traditional cardiovascular risk factors and baPWV was performed, and multivariate line regression analysis was conducted to explore the relevant factors for baPWV. A total of 210 patients were included in the final analyses according to the inclusion criteria. Patients with a high baPWV had a lower lymphocyte count than those with a low baPWV (1.2 ± 0.4 vs. 1.4 ± 0.4, P = 0.004). The NLRs of the low and high bvPWV groups were 3.1 ± 1.5 and 4.0 ± 2.1, respectively; no significant difference was observed. The results suggest that there is a positive relationship between baPWV and NLR (r = 0.403, P = 0.005) and neutrophils (r = 0.319, P = 0.016). Multivariate line regression suggested that NLR was positively associated with baPWV (B = 0.372, P = 0.000). The present results indicate that NLR is independently associated with arterial stiffness in patients with ACS. NLR, an inexpensive, easily measurable, widely available biomarker, could be an additional tool for assessing cardiovascular risk in clinical practice.

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Atteintes cardiovasculaires associées à la polykystose rénale autosomique dominante

Hamzaoui

Lamy

Bellien

et al. 2021

Néphrologie & Thérapeutique

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Correlation between arterial stiffness and inflammatory markers in autosomal dominant polycystic kidney disease patients with preserved renal function

Abstract: In conclusion, our findings revealed increased PTX3 levels and reduced SAEI in patients as compared with controls, while no correlation between inflammatory markers studied and the small artery elasticity.

Cited by 5 publications

References 43 publications

Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases

Association between neutrophil–lymphocyte ratio and arterial stiffness in patients with acute coronary syndrome

Atteintes cardiovasculaires associées à la polykystose rénale autosomique dominante

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