Correlation Between Anterior Chamber Volume and Corneal Biomechanical Properties in Human Eyes

Abstract

Purpose: To investigate the correlation between anterior chamber volume (ACV) and corneal biomechanical properties in healthy and primary angle closure (PAC) eyes.Methods: A total of 79 eyes from 55 participants were enrolled in this study, including 24 eyes from 17 PAC patients and 55 eyes from 38 normal subjects. Anterior chamber volume was detected via swept-source anterior segment optical coherence tomography (OCT), and the cornea biomechanical data were obtained via corneal visualization Scheimpflug technology (Corvis ST). A student's t-test, Chi-square test, Pearson's correlation coefficients, and linear regression were used in the statistical analysis.Results: Anterior chamber volume was significantly associated with a lower deformation altitude (DA) (p = 0.033), higher stiffness parameter (SP-A1) (p = 0.005), younger age (p = 0.001), and higher biomechanical intraocular pressure (bIOP) (p = 0.001). PAC patients were suspected to have a much shallower anterior chamber than healthy participants. In the PAC group, the mean ACV (p < 0.01), SP-A1 (p < 0.01), and bIOP values (p = 0.01) were significantly reduced as compared to the normal group, and DA values (p = 0.02) and age (p = 0.01) were increased as compared to the normal group.Conclusions: Bigger ACV was associated with lower DA values and age, as well as higher SP-A1 and bIOP values. Reduced corneal stiffness was more commonly found in the PAC suspects as compared to their normal counterparts, indicating a protective physiological mechanism for people with shallower anterior chambers that protects against potential elevations of IOP.

Correlation Between Corneal Biomechanics and Anterior Segment Parameters in Healthy Saudi Females

“…On the other hand, mild myopic eyes (63 eyes) in our study showed a highly signi cant positive correlation between IOP g and ACV. This result matched with Cui et al 2019 19 who detected a signi cant association between ACV and a lower deformation altitude (DA), higher stiffness parameter (SP-A1), and higher biomechanical intraocular pressure (bIOP). Cui et al 2019 19 study used corneal visualization Scheimp ug technology (Corvis ST; Oculus Inc., Wetzlar, Germany), to measure the corneal biomechanics.…”

“…This result matched with Cui et al 2019 19 who detected a signi cant association between ACV and a lower deformation altitude (DA), higher stiffness parameter (SP-A1), and higher biomechanical intraocular pressure (bIOP). Cui et al 2019 19 study used corneal visualization Scheimp ug technology (Corvis ST; Oculus Inc., Wetzlar, Germany), to measure the corneal biomechanics. This technology uses an additional high-speed Scheimp ug camera to identify changes in corneal shape.…”

Age distribution and associated factors of cornea biomechanical parameter stress-strain index in Chinese healthy population

“…Previous studies have shown that corneal biomechanics could be affected by multiple factors. A larger anterior chamber volume (ACV) was associated with a lower maximum amplitude at the apex of highest concavity (DA) and a higher stiffness parameter (SP-A1) in primary angle closure (PAC) eyes [ 15 ]. In healthy people, corneal biomechanical parameters were significantly correlated with the corneal curvature, refractive error [ 16 , 17 ] but not with ACV [ 18 ].…”

Age Distribution and Associated Factors of Cornea Biochemical Parameter Stress-Strain Index in Chinese Healthy Population

“…This could be explained by the different population in the studies. Cui believes that the stiffness of cornea would reduce in PAC and compensate for the high intraocular pressure caused by the shallow anterior chamber 13 . But in healthy people, there was no signi cant effect of ACV on corneal stiffness.…”

“…Previous studies have shown that corneal biomechanics could be affected by multiple factors. Cui found that a larger anterior chamber volume (ACV) was associated with a lower maximum amplitude at the apex of highest concavity (DA) and a higher stiffness parameter (SP-A1) in primary angle closure (PAC) eyes 13 . Nemeth studied the relationship between corneal biomechanics and ocular biometrics in healthy people and the results showed that corneal biomechanical parameters were signi cantly correlated with the corneal curvature, but not with ACV 14 .…”