Correlation between Angiotensin Serum Levels and Very-Low-Frequency Spectral Power of Heart Rate Variability during Hemodialysis

Abstract

Cardiovascular regulatory mechanisms that fail to compensate for ultrafiltration and cause hypovolemia during hemodialysis (HD) are not completely understood. This includes the interaction between the autonomic nervous system and the biochemistry that regulates blood pressure and modulates cardiac activity and vascular tone in response to hypovolemia in patients treated with HD. The objective was to evaluate the association of spectral indices of heart rate variability (HRV) with serum levels of angiotensin II, angiotensin 1–7, nitric oxide and total antioxidant capacity during HD. Electrocardiographic records were obtained from 20 patients during HD (3 h), from which HRV data and spectral power data in the very-low-frequency (VLF), low-frequency (LF) and high-frequency (HF) bands were generated. Three blood samples per patient were collected during HD (0.0, 1.5, 3.0 h) to determine the levels of biomarkers involved in the pressor response during HD. Angiotensin II had a positive correlation with VLF (r = 0.390) and with LF/HF (r = 0.359) and a negative correlation with LF (r = −0.262) and HF (r = −0.383). There were no significant correlations between HRV and the other biomarkers. These results suggest that during HD, VLF could reflect the serum levels of angiotensin II, which may be associated with the autonomic response to HD.

Role of autonomous and endocrine factors in immunotropic effects of nitrogenous metabolites in patients with chronic pyelonephritis

“…4). Just now Valle-Mandragon del L et al [41] showing that during hemodialysis angiotensin II had a positive correlation with VLF (r=0,390) and with LF/HF (r=0,359) and a negative correlation with LF (r=-0,262) and HF (r=-0,383) bands. Earlier it was reported that low VLF power has been correlated with low levels of testosterone, while other biochemical markers, such as those mediated by the hypothalamic-pituitary-adrenal axis (e.g., cortisol), have not [40].…”

Sexual dimorphism in the neuro-endocrine regulation of bicycle ergometric test parameters in untrained individuals with dysfunction of the neuro-endocrine-immune complex

“…Authors concluded that although VLF band are influenced by the renin-angiotensin-aldosterone system, they depend primarily on the presence of parasympathetic outflow. However very recently Del Valle-Mandragon L et al [10] showing that during hemodialysis angiotensin II had a positive correlation with VLF band (r=0,390) and with LF/HF (r=0,359) while a negative correlation with LF (r=-0,262) and HF (r=-0,383) bands. Therefore, the contradictions regarding the nature of VLF connections with vagal and sympathetic tone as well as the renin-angiotensin-aldosterone system remain unresolved.…”

„Falling values”: artifacts or source of unique information? Drastically low electrical conductivity of acupuncture points is accompanied by significant deviations of EEG, HRV, immunity, metabolism and GDV parameters

“…Authors concluded that although VLF band are influenced by the renin-angiotensin-aldosterone system, they depend primarily on the presence of parasympathetic outflow. However, del Valle-Mandragon L et al [18] showed that during hemodialysis angiotensin II had a positive correlation with VLF band (r=0.390) and with LF/HF (r=0.359) while a negative correlation with LF (r=-0.262) and HF (r=-0.383) bands. Therefore, the contradictions regarding the nature of VLF connections with vagal and sympathetic tone as well as the renin-angiotensinaldosterone system remain unresolved.…”