Correlation between an integrative oncology treatment program and survival in patients with advanced gynecological cancer

Segev, Yakir; Lavie, Ofer; Stein, Nili; Saliba, Walid; Samuels, Noah; Shalabna, Eiman; Raz, Orit Gressel; Schiff, Elad; Ben‐Arye, Eran

doi:10.1007/s00520-020-05961-5

Cited by 22 publications

(10 citation statements)

References 38 publications

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“…It should be noted that both groups of oncology patients received the same IO treatment regimen, provided by IO practitioners, most frequently including acupuncture. The predominance of acupuncture and manual therapies in the present study are similar to what has been found in previous pragmatic IO studies [ 21 ]. At the same time, all of the study IO practitioners provided instruction to for the self-administration of at least one IO modality (manual, mind–body, or herbal related) at home during the 24-h period following treatments at the study center.…”

Section: Discussionsupporting

confidence: 91%

Nurse-guided patient self-treatment in integrative oncology: a randomized controlled trial

Ben‐Arye

Balneaves

Yaguda

et al. 2023

Support Care Cancer

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Objective Nurses are increasingly becoming involved in integrative oncology (IO) programs. This study examined the additive effect of nurse-provided guidance for self-administered IO therapies on cancer-related fatigue and quality of life (QoL). Methods The study was randomized and controlled, enrolling patients undergoing active oncology treatment with IO interventions for fatigue and other QoL-related outcomes. IO practitioner guidance on self-treatment with manual, relaxation, and/or traditional herbal therapies was provided to patients in both the intervention and control arms. However, patients in the intervention arms also received additional guidance on self-treatment by IO-trained palliative care nurses. All participants were assessed for fatigue and QoL at baseline and at 24-h follow-up, using the Edmonton Symptom Assessment Scale (ESAS) and the Measure Yourself Concerns and Wellbeing (MYCAW) questionnaire tools. Results Of 353 patients recruited, 187 were randomized to the intervention and 166 to the control group. Both groups had similar demographic and oncology-related characteristics. Patients in the intervention arm reported significantly greater improvement in ESAS scores for fatigue ( p = 0.026) and appetite ( p = 0.003) when compared to controls. Conclusion The addition of nurse-provided guidance on self-administration of IO treatments to that provided by IO practitioners further reduced short-term scores for fatigue and improved appetite. The relationship between palliative and IO-supportive cancer care requires further study.

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Section: Discussionsupporting

confidence: 91%

Nurse-guided patient self-treatment in integrative oncology: a randomized controlled trial

Ben‐Arye

Balneaves

Yaguda

et al. 2023

Support Care Cancer

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“…Participants were designated as controls based on their choice not to attend IO treatment sessions. 20,21 The primary outcome was relief of emotional distress,…”

Section: Study Design and Settingmentioning

confidence: 99%

Exploring the effectiveness of a patient‐tailored integrative oncology program on emotional distress during chemotherapy for localized cancer

et al. 2021

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Study objective: There is a need to explore how patient-tailored integrative oncology (IO) programs reduce emotional distress. This study set out to bridge the IO research gap between non-specific, quality of life-related and specific emotionalrelated concerns in chemotherapy-treated patients. Methods: This pragmatic, prospective and preference-controlled study examined patients attending an integrative-physician consultation and weekly IO treatments during adjuvant/neo-adjuvant chemotherapy for localized cancer. Patients choosing to attend ≥4 IO sessions (highly adherent to integrative care, AIC) were compared to low AIC patients using the ESAS (Edmonton Symptom Assessment Scale) anxiety, depression and sleep; and the EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire) emotional functioning scale, at baseline, 6 and 12 weeks. Emotional distress was assessed by ESAS anxiety and depression, considered as the primary study outcomes. Results: Of 439 participants, 260 (59%) were high-AIC and 179 low-AIC, both with similar baseline demographic and cancer-related characteristics. At 6 weeks, high-AIC patients reported greater improvement on ESAS sleep (p = 0.044); withingroup improvement on ESAS anxiety and; and EORTC emotional functioning. Compared with low-AIC, high-AIC patients showed greater improvement on ESAS depression (p = 0.022) and sleep (p = 0.015) in those with high baseline ESAS anxiety scores (≥7); and ESAS anxiety (p = 0.049) for patients moderately anxious (4-6) at baseline. Conclusions: High-AIC was associated with significantly reduced anxiety, depression and sleep severity at 6 weeks, especially those with high-to-moderate baseline anxiety levels. These findings reduce the research gap, suggesting specific emotional-related effects of IO.

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“…An increasing number of randomized-controlled trials have been published on the effective and safe use of IO interventions for the relief of chemotherapy-induced toxicities and improved QoL in the gynecological oncology setting. These include a head-to-head crossover study on the use of acupuncture for the prevention of delayed chemotherapy-induced emesis (Rithirangsriroj et al 2015 ); and pragmatic trials which show greater adherence to paclitaxel-based treatment regimens among patients adhering to a weekly IO treatment program, with implications regarding treatment outcomes (i.e., survival) (Ben-Arye et al 2022 ; Shalom-Sharabi et al 2017 ; Segev et al 2021 ). The findings of this research have led to the design of an integrative gynecological oncology model of care by a multi-disciplinary team of IO-trained practitioners, gynecological oncologists, medical oncologists, oncology nurses, and psycho-oncologists.…”

Section: Introductionmentioning

confidence: 99%

A randomized-controlled trial assessing the effect of intraoperative acupuncture on anesthesia-related parameters during gynecological oncology surgery

Ben‐Arye

Hirsh

Segev

et al. 2023

J Cancer Res Clin Oncol

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Context and objectives The present study examined the impact of intraoperative acupuncture on anesthesia-related parameters in patients undergoing gynecological oncology surgery. Methods Participants underwent preoperative integrative oncology (IO) touch/relaxation treatments, followed by intraoperative acupuncture (Group A); preoperative IO treatments without acupuncture (Group B); or standard care only (Group C). Mean arterial pressure (MAP), heart rate (HR), MAP variability (mean of MAP standard deviation), bispectral index (BIS), and calculated blood pressure Average Real Variability (ARV) were measured intraoperatively. Results A total of 91 patients participated: Group A, 41; Group B, 24; Group C, 26. Among patients undergoing open laparotomy, Group A showed lower and more stable MAP and HR compared to Group B, (MAP, p = 0.026; HR, p = 0.029) and Group C (MAP, p = 0.025). Mean BIS, from incision to suture closing, was lower in Group A (vs. controls, p = 0.024). In patients undergoing laparoscopic surgery, MAP was elevated within Group A ( p = 0.026) throughout surgery, with MAP variability significantly higher in Group A ( P = 0.023) and Group B ( P = 0.013) 10 min post-incision (vs. pre-incision). All groups showed similar intraoperative and post-anesthesia use of analgesic medication. Conclusion Intraoperative acupuncture was shown to reduce and stabilize MAP and HR, and reduce BIS in gynecology oncology patients undergoing laparotomy, with no impact on perioperative analgesic medication use. In the laparoscopic setting, intraoperative acupuncture was associated with elevated MAP. Further research is needed to explore the hemodynamic and BIS-associated benefits and risks of intraoperative acupuncture, and the impact on the use of analgesic drugs in response to these changes.

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Correlation between an integrative oncology treatment program and survival in patients with advanced gynecological cancer

Cited by 22 publications

References 38 publications

Nurse-guided patient self-treatment in integrative oncology: a randomized controlled trial

Nurse-guided patient self-treatment in integrative oncology: a randomized controlled trial

Exploring the effectiveness of a patient‐tailored integrative oncology program on emotional distress during chemotherapy for localized cancer

A randomized-controlled trial assessing the effect of intraoperative acupuncture on anesthesia-related parameters during gynecological oncology surgery

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