Correlation Between an Anomaly of the Intracellular Metabolism of Adenosine Nucleotides and Schizophrenia

Anomaly of the Metabolism of Adenine Nucleotides in the Erythrocytes of Schizophrenic Patients

“…We have found th a t m ethylene blue is also capable of enhancing th e ra te of incorporation of inorganic radioactive p hosphate into th e in tracellular adenosine diphosphate in these cells. We have reported recently th a t this sam e effect was significantly m ore m arked in th e above-m entioned portion of acute schizophrenic populations [1].Several aspects of this finding appeared to us to be w orthy of fu rth e r stu d y . F irst, th ere was th e question ab o u t the pertinence of any correlated biochem ical variable to a behavioral concept as ill-defined as schizophrenia.…”

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W e have shown recently th a t a certain m etabolic p ro p erty of th eir red blood cells characterizes th e m ajo rity of acute schizophrenic p atien ts against control individuals [1]. T he p ro p e rty is a differential response of the intracellular nucleotide m etabolism of th e ery th ro cy te of ab o u t 2/ 3 to 3/ 4 of these p atien ts to m ethylene blue.

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Ενζυμικη Δραστικοτης Της Γλυκοζο - 6 -Φωσφορικης Δευδρογενασης Της Γ - Γλουταμυλ - Τρανσπεπτιδασης Καιτης Λυσοζυμης Εις Την Σχιζοφρενιαν

“…Οί Boszormenyi -Nagy και συν. 44 (1956) άνέφερον μειωμένη ν όξειδωτικήν φωσφορυλίωσιν εις τα ερυθρά αιμοσφαίρια τών σχιζοφρενών.…”