Correlation between amygdala volume and impulsivity in adults with attention-deficit hyperactivity disorder

Tajima-Pozo, Kazuhiro; Ruiz-Manrique, Gonzalo; Yus, Miguel; Arrazola, Juan; Montañes-Rada, Francisco

doi:10.1017/neu.2015.34

Cited by 18 publications

(17 citation statements)

References 27 publications

(36 reference statements)

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“…In healthy subjects, negative (Boes et al, 2009 ; Matsuo et al, 2009 ; Schilling et al, 2012 , 2013 ) or positive (Gardini et al, 2009 ; Schilling et al, 2012 ; Cho et al, 2013 ) correlations were both reported between impulsivity and GMV/cortical thickness in frontal, temporal regions and amygdala. The significant correlations between GMV in the orbitofrontal cortex (OFC)/amygdala and impulsivity were also found in patients with major depressive disorder, alcoholism, attention-deficit/hyperactivity disorder, posttraumatic stress disorder, antisocial personality disorder and bipolar disorder (Antonucci et al, 2006 ; Tajima-Pozo et al, 2015 ). However, the relationship between impulsivity and GMV in IGD adolescents was largely unknown.…”

Section: Introductionmentioning

confidence: 99%

Altered Structural Correlates of Impulsivity in Adolescents with Internet Gaming Disorder

Yang

et al. 2016

Front. Hum. Neurosci.

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Recent studies suggested that internet gaming disorder (IGD) was associated with impulsivity and structural abnormalities in brain gray matter (GM). However, no morphometric study has examined the association between GM and impulsivity in IGD individuals. In this study, 25 adolescents with IGD and 27 healthy controls (HCs) were recruited, and the relationship between Barratt impulsiveness scale-11 (BIS) score and gray matter volume (GMV) was investigated with the voxel-based morphometric (VBM) correlation analysis. Then, the intergroup differences in correlation between BIS score and GMV were tested across all GM voxels. Our results showed that the correlations between BIS score and GMV of the right dorsomedial prefrontal cortex (dmPFC), the bilateral insula and the orbitofrontal cortex (OFC), the right amygdala and the left fusiform gyrus decreased in the IGD group compared to the HCs. Region-of-interest (ROI) analysis revealed that GMV in all these clusters showed significant positive correlations with BIS score in the HCs, while no significant correlation was found in the IGD group. Our findings demonstrated that dysfunction of these brain areas involved in the behavior inhibition, attention and emotion regulation might contribute to impulse control problems in IGD adolescents.

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Section: Introductionmentioning

confidence: 99%

Altered Structural Correlates of Impulsivity in Adolescents with Internet Gaming Disorder

Yang

et al. 2016

Front. Hum. Neurosci.

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“…For example, the fronto-cerebellar networks have been implicated in impairments of cognitive control (e.g., over-riding impulses) in both ADHD and obesity [40,41]; the ability to consider future consequences/adjust behaviours [41]; and the inhibition of eating behaviour [42]. Likewise, the amygdala and hippocampus have been associated with impulsivity symptoms in ADHD [43] as well as weight gain and overeating behaviours such as continuing to eat even when sated [44][45][46][47]. Finally, the orbital frontal cortex has been linked to impairments in cognitive and attentional control in ADHD [48], but also potentially to selection and consumption of calorie-rich foods [49] and sensitized reactivity to (foodrelated) reward [50].…”

Section: Discussionmentioning

confidence: 99%

Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?

et al. 2019

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There is an extensive body of literature linking ADHD to overweight and obesity. Research indicates that impulsivity features of ADHD account for a degree of this overlap. The neural and polygenic correlates of this association have not been thoroughly examined. In participants of the IMAGEN study, we found that impulsivity symptoms and body mass index (BMI) were associated (r = 0.10, n = 874, p = 0.014 FWE corrected), as were their respective polygenic risk scores (PRS) (r = 0.17, n = 874, p = 6.5 × 10 −6 FWE corrected). We then examined whether the phenotypes of impulsivity and BMI, and the PRS scores of ADHD and BMI, shared common associations with whole-brain grey matter and the Monetary Incentive Delay fMRI task, which associates with reward-related impulsivity. A sparse partial least squared analysis (sPLS) revealed a shared neural substrate that associated with both the phenotypes and PRS scores. In a last step, we conducted a bias corrected bootstrapped mediation analysis with the neural substrate score from the sPLS as the mediator. The ADHD PRS associated with impulsivity symptoms (b = 0.006, 90% CIs = 0.001, 0.019) and BMI (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. The BMI PRS associated with BMI (b = 0.014, 95% CIs = 0.003, 0.033) and impulsivity symptoms (b = 0.009, 90% CIs = 0.001, 0.025) via the neuroimaging substrate. A common neural substrate may (in part) underpin shared genetic liability for ADHD and BMI and the manifestation of their (observable) phenotypic association.

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“…delay-discounting - Ainslie, 1974). Interestingly, patients with damage to the amygdala or to the orbital frontal cortex show poor decision-making and are often described as impulsive (Gopal et al, 2013;Tajima-Pozo et al, 2015). These same brain regions are also thought to be involved in the mediation and aetiology of psychopathic traits (Stratton et al, 2015).…”

Section: 1factor 1: Interpersonal/affectivementioning

confidence: 99%

Psychopathy and impulsivity: The relationship of psychopathy to different aspects of UPPS-P impulsivity

Gray

Weidacker

Snowden

2019

Psychiatry Research

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Impulsivity is thought to be a major component of psychopathy. However, impulsivity is a multi-faceted concept, and different facets may have differential relationships to psychopathy. We measured impulsivity via the UPPS-P in a sample of prisoners and in patients in a personality disorder service resident in secure psychiatric care. Psychopathy in the prison sample was measured via the clinician-rated Psychopathy Checklist: Screening Version and in the patients via the Psychopathy Checklist-Revised. We found that the Lifestyle/Antisocial factor (Factor 2) was associated with acting rashly when emotional (Negative Urgency and Positive Urgency). However, the Interpersonal/Affective factor (Factor 1) was associated with reduced impulsivity in the domains of premeditation and perseverance, and its unique variance was also associated with less rash behavior. The Interpersonal facet (Facet 1) was particularly associated with reduced impulsivity. The results show that individuals with high Interpersonal traits of psychopathy can plan carefully and are persistent in their goals. This may underpin instrumental violence and criminal behavior. Thus, a simple unitary understanding of the relationship between psychopathy and impulsivity may not be valid and may distort the multifaceted relationship between the two concepts that could assist in the assessment and management of psychopathic offenders.

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Correlation between amygdala volume and impulsivity in adults with attention-deficit hyperactivity disorder

Cited by 18 publications

References 27 publications

Altered Structural Correlates of Impulsivity in Adolescents with Internet Gaming Disorder

Altered Structural Correlates of Impulsivity in Adolescents with Internet Gaming Disorder

Do ADHD-impulsivity and BMI have shared polygenic and neural correlates?

Psychopathy and impulsivity: The relationship of psychopathy to different aspects of UPPS-P impulsivity

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