Correlation between ambulatory blood pressure variability and vasodilator function in middle-aged normotensive individuals

Liang, Minlie; Xu, Sheng‐Quan; Luo, Shunxiang; Miao, Fei; Lei, Yingfeng; Zhong, Wenliang

doi:10.1097/mbp.0000000000000267

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Проведенное авторами исследование подтвердило связь показателей суточной вариабельности АД с эндотелиальной дисфункцией и сосудистым воспалением. Результаты, полученные учеными, совпадают с результатами исследований, где повышенные значения вариабельности АД ассоциировали со снижением эндотелийзависимой и эндотелийнезависимой вазодилатации как у пациентов с АГ, так и у больных с нормальными цифрами АД [14,15]. Имеются противоречивые данные о связи воспаления и повышенной вариабельности АД.…”

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Blood pressure variability, endothelial dysfunction, and C-reactive protein levels in arterial hypertension in combination with coronary artery disease

et al. 2021

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Background. Recently, the role of increased variability in blood pressure (BP) as a new risk factor for cardiovascular events in patients with arterial hypertension (AH) in combination with coronary heart disease (CHD) has been discussed. At the same time, the mechanisms of the participation of blood pressure variability in the development of atherosclerotic damage to the vascular wall are not well understood. Aim. To study the nature of the relationship between the indicators of daily BP variability, vasomotor function of the endothelium and highly sensetive C-reactive protein (hs-CRP) in patients with AH combined with CAD. Materials and methods. 80 patients with AH and CAD (55.50.7 years) were examined. The study assessed the BP variability according to 24-hour monitoring of BP, vasomotor function of the brachial artery endothelium, and the level hs-CRP in blood serum. Results. Increased indicators of diurnal BP variability were recorded in 48.8% of patients. There were revealed signs of endothelial dysfunction in patients in the form of a decrease in endothelium-dependent vasodilation (EDV) to 5.380.48% and an insufficient increase in endothelium-independent vasodilation (EIV) to 15.821.24%. Patients with increased variability of BP differed from patients with normal variability of BP by higher values of hs-CRP (2.980.71 and 1.560.33 mg/l; p0.05), a less pronounced response to administration nitroglycerin when evaluating EIV (13.231.79 and 17.700.77%; p0.05). Correlation relationships of variability of systolic BP (SBP) in the daytime with EVD were recorded (r=-0.44; p=0.012); variability of diastolic BP (DBP) in the daytime with EIV (r=-0.50; p=0.003); nighttime variability of DBP with EIV (r=-0.43; p=0.013). Relationships between the level of hs-CRP and the variability of SBP in the daytime (r=0.30; p=0.008) and with EVD (r=-0.47; p=0.007) were established. In patients with increased variability of SBP, the likelihood of registering an increased level of hs-CRP is 1.6 times higher OR 1.58 (95% CI 1.0142.451; p=0.043). In patients with depletion of the vasodilation reserve during the test with nitroglycerin (EIV), an increase in blood pressure variability is recorded 1.2 times more likely OR 1.22 (95% CI 1.0121.478; p=0.037). Conclusion. The revealed association of the daily variability of BP with indicators of vasomotor function of the endothelium and a marker of the inflammatory reaction of the vascular wall may indicate the presence of a pathogenetic relationship between the parameters that determine the development of adverse events in patients with AH and CAD.

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Section: Discussionunclassified

Blood pressure variability, endothelial dysfunction, and C-reactive protein levels in arterial hypertension in combination with coronary artery disease

et al. 2021

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Research Progress of Blood Pressure Variability and Diabetes and Vascular Disease

陶¹

2018

ACM

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Blood pressure variability is the degree of fluctuation of blood pressure and blood pressure in a certain time. The increase of blood pressure variability is independently related to cardio cerebral and renal vascular events. It also predicts target organ damage and vascular structural changes at subclinical level. BPV plays a key role in diabetes and its vascular complications. Diabetes can also increase blood pressure variability. For diabetic patients, improving glucose metabolism and BPV in vivo is of great clinical significance in reducing target organ damage.

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Ambulatory Blood Pressure Characteristics of Patients with Alzheimer’s Disease: A Multicenter Study from China

Wang

Ren

et al. 2021

JAD

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Background: Previous studies revealed that abnormal blood pressure (BP) plays an important role in the pathogenesis of Alzheimer’s disease (AD). However, little is known about the ambulatory BP characteristics of AD in the mild or severe stage. Objective: We explored the ambulatory BP characteristics of AD in the mild or severe stage. Methods: In the present study, 106 AD patients (42.5%male, average age 81.6 years) were enrolled from three centers in China. Clinal BP measurements at the supine and standing positions, neurological evaluations, and the 24 h ambulatory BP monitoring were performed. Statistical methods included the two-sample t-test, chi-square test, Spearman correlation analysis, and multivariate linear regression. Results: In the 106 AD patients, 49.2%, 36.8%, and 70%of patients had 24 h, daytime, and nighttime systolic hypertension, respectively, while 19.8%, 29.2%, and 5.7%had 24 h, daytime, and nighttime diastolic hypotension. The prevalence of the reduced and reverse dipping pattern was 34.0%and 48.1%for systolic BP and 32.1%and 45.3%for diastolic BP, respectively. The daytime diastolic BP was significantly correlated with cognitive performance. After adjustment for age, sex, and body mass index, only daytime diastolic BP was associated with remarkable cognitive deterioration (p≤0.008). Further, AD patients in the severe stage had significantly lower levels of the 24 h, daytime, and nighttime diastolic BP, compared with those in the mild stage. Conclusion: In general, AD patients were featured with high nighttime systolic BP, low daytime diastolic BP, and abnormal circadian BP rhythm of reduced and reverse dipping. The diastolic BP, especially daytime diastolic BP, was adversely correlated with the cognitive deterioration in AD.

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Correlation between ambulatory blood pressure variability and vasodilator function in middle-aged normotensive individuals

Cited by 3 publications

References 35 publications

Blood pressure variability, endothelial dysfunction, and C-reactive protein levels in arterial hypertension in combination with coronary artery disease

Blood pressure variability, endothelial dysfunction, and C-reactive protein levels in arterial hypertension in combination with coronary artery disease

Research Progress of Blood Pressure Variability and Diabetes and Vascular Disease

Ambulatory Blood Pressure Characteristics of Patients with Alzheimer’s Disease: A Multicenter Study from China

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