Correlation between adrenal function, growth hormone secretion, and insulin sensitivity in children with idiopathic growth hormone deficiency

Ciresi, Alessandro; Radellini, Stefano; Vigneri, Enrica; Guarnotta, Valentina; Bianco, Jessica; Mineo, Mariagrazia Irene; Giordano, Carla

doi:10.1007/s40618-017-0747-2

Cited by 3 publications

(2 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, research indicates that vitamin D can promote the absorption of phosphorus, calcium, and other substances, accelerate bone growth, and improve bone development. As it is an important factor that promotes bone growth and development, vitamin D can also be combined with rhGH for treating GHD [ 15 , 16 ]. In this study, rhGH and vitamin D were combined to treat children with GHD in our hospital.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

et al. 2022

View full text Add to dashboard Cite

Objective. Growth hormone deficiency (GHD) refers to the complete or partial lack of pituitary growth hormone synthesis and secretion. This study is aimed at investigating the efficacy of vitamin D and recombinant human growth hormone (rhGH) in children with GHD. Methods. A total of 100 children with GHD at our hospital were included between 1st January 2018 and 31st October 2020. The patients were divided into a study group ( n = 70 , received vitamin D combined with rhGH) and a control group ( n = 30 , received rhGH). The growth and development (bone age, growth rate, and height), bone metabolism (bone alkaline phosphatase (BAP), β-collagen degradation product (β-CTX), osteocalcin (OC), and amino-terminal propeptide type I procollagen (PINP)), insulin-like growth factor 1 (IGF-1), ghrelin, and adverse reactions in the two groups were measured before and 12 months after treatment. Results. There were no significant differences in the bone age, growth rate, and height between the two groups before treatment. After 12 months of treatment, the bone age, growth rate, and height of the study group were significantly higher than those of the control group. After 12 months of treatment, the levels of serum BAP, PINP, and OC in the study group were significantly higher than those in the control group, while the levels of β-CTX in the study group were significantly lower than those in the control group. The serum IGF-1 level in the study group was significantly higher than that in the control group, while the ghrelin level in the study group was lower. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion. Combined rhGH and vitamin D treatment can promote growth and development, improve bone metabolism, and regulate IGF-1 and ghrelin levels.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This suggests that if there is a normal secretion of ACTH, GH stimulates adrenal androgen secretion in GHD patients. Conversely, GHD patients present an increased cortisol/cortisone ratio, and GH replacement therapy reduces the increased cortisol production [138]. However, in normal subjects or laboratory animals, the stimulation of adrenal steroidogenesis by GH seems to be restricted to the fetal period [139].…”

Section: Ghd and Adrenal Glandsmentioning

confidence: 99%

Growth Hormone Deficiency: Is It Just a Problem of Growth Impairment? Part II

Devesa¹

2020

Growth Disorders and Acromegaly

View full text Add to dashboard Cite

As stated in the first part of this review, growth hormone (GH) acts on all organs and tissues, and untreated GH-deficient (GHD) patients suffer from several affectations occurring as a consequence of the lack of this key hormone. In the second part of this review, we will analyze the effects of GH on the liver, the kidney, the adrenal glands, the skeletal muscles, the bones, the hematopoietic system, the gastrointestinal system, and the adverse effects that may occur in these organs and systems in the GH deficiency not treated in children and adults. Apart from these, we conclude that GH is a co-hormone that seems to be necessary for the physiological actions of other important hormones in humans.

show abstract

Partial empty sella syndrome, GH deficiency and transient central adrenal insufficiency in a patient with NF1

2020

View full text Add to dashboard Cite

Correlation between adrenal function, growth hormone secretion, and insulin sensitivity in children with idiopathic growth hormone deficiency

Cited by 3 publications

References 49 publications

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

Effect of Vitamin D Combined with Recombinant Human Growth Hormone in Children with Growth Hormone Deficiency

Growth Hormone Deficiency: Is It Just a Problem of Growth Impairment? Part II

Partial empty sella syndrome, GH deficiency and transient central adrenal insufficiency in a patient with NF1

Contact Info

Product

Resources

About