Correlation Between Adiponectin Receptor with Indices of Glucose Homeostasis and Mediators Of Insulin Sensitivity in Type 2 Diabetic Rats Treated With Puguntano (Curanga felterrae Lour.) Leaf Extract
Abstract:ABSTRACT
Objective: Adiponectin receptors (AdipoR) regulates metabolism and has anti-inflammatory and insulin-sensitizing effects. We aimed to determine the relationships between AdipoR with parameters of glucose homeostasis (FPG, insulin, and HOMA-IR), and insulin sensitivity (PPAR-γ and p38MAPK) in T2DM rats treated with puguntano (Curanga felterrae Lour.) leaf extract.
Methods: T2DM was induced in Wistar rats aged 8–10 weeks and weighing 180–200 g by high-fat diet (HFD) feeding and low-dose stre… Show more
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