Correlation between adipocytokines and AGE products in diabetic and non-diabetic patients with myocardial infarction

Memon, Aisha; Rahman, Mohammad Masudur; Alghasham, Abdullah; Hamid, Sadaf; Hamid, Qamar

doi:10.1007/s11164-013-1298-6

Cited by 3 publications

(4 citation statements)

References 35 publications

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“…Also, similar results were reported by Al Sheikh, who studied serum leptin levels in correlation with T2DM in a sample of Saudi males; she found a significant rise in serum leptin in the diabetic group versus non-diabetic group. 7 In accordance with our results, the study of Memon et al 13 studied serum values of adipocytokines and advanced glycation end products in diabetic and non-diabetic cases with myocardial infarction, and they reported that T2DM patients with or without MI had significantly higher leptin values than controls. 13 In this study, leptin had positive associations with RBP4, BMI, FBG, and HbA1C.…”

Section: Discussionsupporting

confidence: 90%

“… 7 In accordance with our results, the study of Memon et al 13 studied serum values of adipocytokines and advanced glycation end products in diabetic and non-diabetic cases with myocardial infarction, and they reported that T2DM patients with or without MI had significantly higher leptin values than controls. 13 In this study, leptin had positive associations with RBP4, BMI, FBG, and HbA1C. Similar results have been achieved by Memon et al, 13 reported that there was a significant positive correlation between leptin and BMI and FBG in T2DM patients they explained their results by that inflammation is playing a pivotal role in cardiovascular complication the pathogenesis in T2DM.…”

Section: Discussionsupporting

confidence: 90%

“… 13 In this study, leptin had positive associations with RBP4, BMI, FBG, and HbA1C. Similar results have been achieved by Memon et al, 13 reported that there was a significant positive correlation between leptin and BMI and FBG in T2DM patients they explained their results by that inflammation is playing a pivotal role in cardiovascular complication the pathogenesis in T2DM.…”

Section: Discussionsupporting

confidence: 88%

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Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. A case-control study

Ali

Hegazy

Hashem

2020

SMJ

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Objectives: To evaluate adipokine serum values of irisin, retinol-binding protein 4, and leptin in Saudi cases with type 2 diabetes mellitus (T2DM) for providing markers of T2DM macrovascular complications. Methods: This case-control research was carried out at Erfan Hospital, Jeddah, Saudi Arabia. The study included 138 subjects, classified into 3 groups: 46 T2DM patients with macrovascular complications, 46 T2DM without macrovascular complications, and 46 controls. Participants evaluated clinically and some biochemical parameters were measured. Results: Diabetic with and without macrovascular complications showed elevation of retinol-binding protein 4 (RBP4) and leptin; decreased irisin serum levels versus controls. Serum irisin was lower (p=0.007), while RBP4 was higher (p<0.0001) in T2DM patients with macrovascular complications versus without. Irisin showed negative correlations with fasting blood glucose (FBG), insulin, homeostatic model assessment of insulin resistance (HOMA-IR), RBP4, hemoglobin A1C (HbA1C), triglyceride, cholesterol, and low-density lipoprotein cholesterol. While RBP4 showed positive correlations with fasting blood glucose, insulin, HOMA-IR, leptin, and HbA1c; but a negative association with high-density lipoprotein cholesterol. Conclusion: Type 2 DM patients had raised RBP4 and leptin, but lower irisin levels versus controls. Irisin was lower, but RBP4 was higher in T2DM patients with macrovascular complications versus without, suggesting T2DM patients in pro-inflammatory conditions. These results suggested that irisin is protective, while RBP4 is a risk factor for T2DM macrovascular complications.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

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Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. A case-control study

Ali

Hegazy

Hashem

2020

SMJ

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“…Furthermore, there are a number of complications associated with the disease. These include diabetic retinopathy, diabetic neuropathy, kidney failure, foot ulcers and eventual limb amputation, and increased risk of heart disease and stroke [4][5][6][7]. Therefore, it is necessary and urgent to discover novel and more effective agents to treat diabetes.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives

et al. 2014

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A series of new 3-arylsulfonylimidazolidine-2,4-diones (2a-2p) were synthesized by reacting imidazolidine-2,4-diones (1a-1e) with arylsulfonyl chlorides in the presence of triethyl amine. The imidazolidine-2,4-diones (1a-1e) were in turn synthesized from the corresponding ketones through Bucherer-Bergs reaction. All the synthesized compounds were characterized on the basis of their spectral (IR, 1 H and 13 C NMR and MS) and microanalytical data. The hypoglycemic activity of the compounds (2a-2p) was evaluated using alloxanized diabetic rat model. Compound 2a showed an excellent activity with a reduction in the blood glucose level of -286 ± 7 mg/dL after 5 h of drug administration as compared to -270 ± 8 mg/dL for glipizide. The hypoglycemic activity of compound 2b (-268 ± 9 mg/dL) was also comparable to the standard drug. However, only moderate activity was observed for compound 2e.

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A critical role for the small GTPase Rac1 in insulin signaling that regulates glucose uptake in skeletal muscle

Satoh

Takenaka

2019

Res Chem Intermed

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Correlation between adipocytokines and AGE products in diabetic and non-diabetic patients with myocardial infarction

Cited by 3 publications

References 35 publications

Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. A case-control study

Evaluation of irisin, retinol-binding protein 4, and leptin serum levels as biomarkers of macrovascular complications involvement in Saudi type 2 diabetes mellitus. A case-control study

Synthesis and in vivo hypoglycemic activity of new imidazolidine-2,4-dione derivatives

A critical role for the small GTPase Rac1 in insulin signaling that regulates glucose uptake in skeletal muscle

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