Correlation between acute rejection severity and CD8-positive T cells in living related liver transplantation

Katayama, Nobuyuki; Sugitani, Masahiko; Takano, Seigo; Sheikh, Aleemuzzaman; Takayama, Tadatoshi; Haga, Hironori; Tanaka, Kōichi; Yamabe, Hirohiko

doi:10.1016/j.trim.2006.03.002

Cited by 17 publications

(16 citation statements)

References 15 publications

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“…This indicated that the involvement of CD8 in the process of rejection was more than that of CD4. This is in agreement with the results of Kubota et al (2006), who reported that mainly CD8 + cells, rather than CD4 + cells, were detected in the portal tract in ACR cases. Also, this indicated the involvement of regulatory T cells (CD4) in the recurrence of HCV after liver transplantation, and this is in agreement with the result of other researchers (Carpentier et al, 2009) who found that CD4 plays an important role in HCV recurrence.…”

Section: Discussionsupporting

confidence: 93%

“…This is in agreement with the results of Kubota et al (2006), who found that the percentages of infiltrating CD4 + and CD8 + cells in portal tracts, on average for all ACR specimens examined, were B40 and 60%, respectively, and different from the results of McCaughan et al (1990), who reported that CD4 + and CD8 + cells in ACR cases were present in approximately equal numbers in the portal tracts. This difference may be because of the difference in the technique as they had used frozen tissues.…”

Section: Discussionsupporting

confidence: 89%

“…Comparison between anti-CD4 immunostain in a recipient of a case of recurrent hepatitis showed increased CD4 + cells in the portal tract on the right side more than anti-CD8 on the left side (streptavidin-biotin; DAB chromogen, Â 400). et al 265 biopsies was 36%, while there was no significant correlation when counted in hepatic lobules and this matching with those of Kubota et al (2006) who detect that CD4 + cells tended to decrease with the increase of RAI.…”

Section: Discussionsupporting

confidence: 57%

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Prognostic factors in liver transplantation, with a focus on the role of CD4 and CD8

Elsawy¹,

Agina²,

Elbalshi³

et al. 2012

Egyptian Journal of Pathology

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Aim The aim of this studywas to assess liver tissues from both donors and their recipients of liver transplantation in order to analyze the prognostic factors that influence the prognosis of liver transplantation, especially T-cell subpopulations, to determine their relationship with the degree of severity of ACR according to the Banff schema (1997) and recurrent hepatitis C according to the modified Knodell and Ishak score (1995). Materials and methodsThis was a retrospective study of 38 needle liver biopsy specimens, 19 specimens collected before transplantation from donors and 19 specimens collected after transplantation from recipients. Nine cases were studied for rejection and 10 cases for recurrent hepatitis C. All cases were formalin-fixed and paraffin-embedded, examined routinely by hematoxylin and eosin, and submitted for immunohistochemical staining for CD4 and CD8. Immunohistological findings were correlated to the Rejection Activity Index score according to the Banff schema (1997), and the grade of recurrent hepatitis C according to the modified Knodell and Ishak score (1995) was compared. In cases of acute cellular rejection (ACR), an increased number of CD8 + cells than CD4 + cells in the donor increased the risk of ACR after transplantation. In recipients, the number of CD8 + cells increased according to the ACR grade, whereas CD4 + cells tended to decrease. In recurrent hepatitis C, the number of CD4 + cells increased with an increase in the grade of recurrent hepatitis, whereas CD8 + cells tended to decrease. ResultsThe results indicate that CD8 + cells play important roles in the ACR severity of living-related liver transplantation, whereas CD4 + cells play a major role in recurrent hepatitis C. Thus, the ratio of CD4 and CD8 in both the donor and the recipient can be helpful in the prediction of the outcome of liver transplantation.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 57%

See 1 more Smart Citation

Prognostic factors in liver transplantation, with a focus on the role of CD4 and CD8

Elsawy¹,

Agina²,

Elbalshi³

et al. 2012

Egyptian Journal of Pathology

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“…Heart transplant rejection involves lymphocyte activation and a variety of effector mechanisms [1][2][3][4][5]. Cyclosporin A is a strong immunosuppressive agent which selectively effects T lymphocytes and inhibits the activation of helper T cells and reactivity to IL-2.…”

Section: Introductionmentioning

confidence: 99%

Expression of lymphocyte coding genes in peripheral blood and lymphocyte infiltration in cardiac tissues influenced by cyclosporin A in heterotopic heart transplantation model in rats

Zhang

et al. 2013

Transplant Immunology

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“…It is generally accepted that T cell-mediated immune reactions play a pivotal role in the pathogenesis of ACR, and CD8+ cytotoxic T cells induce target cell death during acute allograft rejection in liver allograft tissues [6-8]. Cytotoxic molecules such as perforin, granzyme B and T-cell intracellular antigen-1 (TIA-1) are present in the cytoplasmic granules of cytotoxic T cells and function at the effector end of the acute rejection process [9].…”

Section: Introductionmentioning

confidence: 99%

Local distribution analysis of cytotoxic molecules in liver allograft is helpful for the diagnosis of acute cellular rejection after orthotopic liver transplantation

et al. 2012

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BackgroundAs it is often difficult for a transplant pathologist to make a definite diagnosis of acute cellular rejection (ACR) by routine morphological analysis of liver allograft biopsy, supplementary methods and objective markers are needed to facilitate this determination.MethodsTo evaluate the diagnostic value of cytotoxic molecules in ACR episodes, immunohistochemical staining for perforin, granzyme B and T-cell intracellular antigen-1 (TIA-1) were performed in liver allograft biopsies. The positive cells in the portal tract area and lobules were counted separately to investigate the distribution of the cytotoxic molecules.ResultsThe immunohistochemical study showed that the overall positive rates for the three markers were not significantly different between the ACR and non-ACR groups. However, in the portal tract area, perforin-, granzyme B- and TIA-1-positive cells in the ACR group were significantly more than those in the non-ACR groups. In the lobules, perforin- and granzyme B-positive cells in the ACR group were significantly more than those in the biliary complication and opportunistic infection groups, while TIA-1-positive cells was significantly fewer than those in non-ACR groups. The numbers of positive cells in the portal tract area correlated with the rejection activity index of ACR.ConclusionsThese results indicate that, though the overall positive rates have nonsense in ACR diagnosis, the quantification and local distribution analysis of cytotoxic molecule positive cells in liver tissue is helpful for differential diagnosis and severity evaluation of ACR following liver transplantation.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2292255038100487

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Correlation between acute rejection severity and CD8-positive T cells in living related liver transplantation

Cited by 17 publications

References 15 publications

Prognostic factors in liver transplantation, with a focus on the role of CD4 and CD8

Prognostic factors in liver transplantation, with a focus on the role of CD4 and CD8

Expression of lymphocyte coding genes in peripheral blood and lymphocyte infiltration in cardiac tissues influenced by cyclosporin A in heterotopic heart transplantation model in rats

Local distribution analysis of cytotoxic molecules in liver allograft is helpful for the diagnosis of acute cellular rejection after orthotopic liver transplantation

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