Correlation Between Acute and Late Toxicity in 973 Prostate Cancer Patients Treated With Three-Dimensional Conformal External Beam Radiotherapy

Jereczek-Fossa, Barbara A.; Zerini, Dario; Fodor, C.; Santoro, Luigi; Serafini, Flavia; Cambria, Raffaella; Vavassori, Andrea; Cattani, Federica; Garibaldi, Cristina; Gherardi, F.; Ferrari, Annamaria; Rocco, Bernardo; Scardino, E.; Cobelli, Ottavio De; Orecchia, Roberto

doi:10.1016/j.ijrobp.2009.07.1742

Cited by 53 publications

(32 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Second, there was a short follow-up period. While a lower incidence of acute toxicity might reduce the development of subsequent late toxicity, 25,37,38 WPRT could result in worse late toxicity because the field is larger than that irradiated during PORT. Therefore, late toxicity should be assessed during longer follow-up.…”

Section: Discussionmentioning

confidence: 99%

Comparison of dosimetric parameters and acute toxicity after whole-pelvicvsprostate-only volumetric-modulated arc therapy with daily image guidance for prostate cancer

Ishii¹,

Ogino²,

Hosokawa³

et al. 2016

BJR

View full text Add to dashboard Cite

Results: The mean rectal dose, the rectal volume receiving $30 Gy (V 30Gy ), rectal V 50Gy, the mean bladder dose, bladder V 30Gy and bladder V 50Gy were significantly increased in the WP group (p , 0.05 each); however, the rectal V 70Gy did not differ between groups (p 5 0.101), and the bladder V 70Gy was significantly lower in the WP group (p 5 0.029). The WP group experienced a significantly increased frequency of acute grade 2 diarrhoea relative to the PO group (5.9% vs 0%; p 5 0.015). No differences were seen between the WP and PO groups in terms of acute grade 2 proctitis (10.1% vs 6.7%; p 5 0.360) and genitourinary (GU) toxicity (12.6% vs 10.5%; p 5 0.620). Conclusion: Despite larger rectum and bladder volumes at low-and medium-dose levels, WP VMAT resulted in no significant increase in acute proctitis or GU toxicity when compared with PO VMAT. Advances in knowledge: This study demonstrates that whole-pelvic radiotherapy has comparable acute toxicity to those observed with prostate-only radiotherapy when VMAT with daily image guidance is used.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of dosimetric parameters and acute toxicity after whole-pelvicvsprostate-only volumetric-modulated arc therapy with daily image guidance for prostate cancer

Ishii¹,

Ogino²,

Hosokawa³

et al. 2016

BJR

View full text Add to dashboard Cite

show abstract

“…Correlation between acute and late toxicity was also expected. 44,45 Genetic features are involved in toxicity; however, this aspect was not investigated in our series. 46,47 The fact that the significance of DVH parameter, NTCP and previous surgery was not confirmed in multivariate analysis is probably owing to the underlying assumption of logistic multivariate regression, whereas more general models could be used in univariate analysis.…”

Section: Discussionmentioning

confidence: 91%

No increase in toxicity of pelvic irradiation when intensity modulation is employed: clinical and dosimetric data of 208 patients treated with post-prostatectomy radiotherapy

Jereczek‐Fossa

Ciardo

Ferrario

et al. 2016

BJR

Self Cite

View full text Add to dashboard Cite

“…A last issue is related to the compelling confirmations of the consequential nature of late radiation-induced urinary toxicity, which were recently reported in large, prospectively followed cohorts (5,9,13,(22)(23)(24)(25)(26)(27). This suggests that a relevant fraction of late urinary events are a "consequence" of the exuberant repair process following the acute inflammatory phase and it means that any effort to reduce acute toxicity may impact the occurrence of late events.…”

Section: The Radiation-induced Urinary Syndrome -Facts and Figuresmentioning

confidence: 99%

Understanding Urinary Toxicity after Radiotherapy for Prostate Cancer: First Steps Forward

Rancati

Palorini

Cozzarini

et al. 2017

Tumori

View full text Add to dashboard Cite

Tumori 2017; 103(5): [395][396][397][398][399][400][401][402][403][404] REVIEW -BONADONNA LECTURE SERIES may be differently related to the absorbed dose. For example, rectal bleeding arises as a serial effect and is mainly related to the absorption of high doses in small rectal mucosa volumes, whilst fecal incontinence is related to intermediate doses absorbed by large rectal volumes.The development of reliable models of radiation-induced toxicities along with the available level of technology has determined an efficient improvement of the treatment plans, even in dose-escalated or hypofractionated regimens. This is particularly true for moderate and severe rectal toxicities, which had an incidence close to 20% in the 1990s while in the most recent publications they have fallen below 7%-10%.However, an analogous result has not yet been reached in urinary symptoms. This is mainly due to the difficulty in sparing the bladder, which is partially but unavoidably included in the target volume, as well as to the clear lack of knowledge concerning the predictors of urinary toxicity. The main reason for this deficiency is probably the difficulty in following for a sufficiently long time a large number of patients whose clinical and dosimetry data need to be individually and prospectively collected with proper evaluation of urinary symptoms. Some important symptoms (e.g., incontinence) may indeed continuously arise after radiation therapy and their incidence reaches a plateau only many years (typically 5-8) after treatment. The fulfilment of reliable models of radiation-induced urinary sequelae is therefore made particularly challenging by the complexity of symptoms, their evolution over time, and the strong dependence on the baseline situation.It is widely acknowledged that radiation-induced toxicity is a multifactorial problem, depending not only on the delivered

show abstract

Correlation Between Acute and Late Toxicity in 973 Prostate Cancer Patients Treated With Three-Dimensional Conformal External Beam Radiotherapy

Cited by 53 publications

References 26 publications

Comparison of dosimetric parameters and acute toxicity after whole-pelvicvsprostate-only volumetric-modulated arc therapy with daily image guidance for prostate cancer

Comparison of dosimetric parameters and acute toxicity after whole-pelvicvsprostate-only volumetric-modulated arc therapy with daily image guidance for prostate cancer

No increase in toxicity of pelvic irradiation when intensity modulation is employed: clinical and dosimetric data of 208 patients treated with post-prostatectomy radiotherapy

Understanding Urinary Toxicity after Radiotherapy for Prostate Cancer: First Steps Forward

Contact Info

Product

Resources

About