Correlation between abscess size and liver function tests in cases of liver abscess

Abstract

Background: Liver abscess has shown a major change in demographics, etiology, diagnosis, and treatment over the past 100 years. The modern diagnostics like ultrasound and computed tomography to locate and drain the abscess have reduced the mortality to 2-12%. However, due to the complications of liver abscess especially the amebic ones the morbidity is still high. This study aims to study the correlation of various LFT parameters with abscess volume for early detection of high risk patients and early treatment thus reducing morbidity.Methods: The study was conducted over a period of 6 months on 50 patients of liver abscess. History and physical examination was done. All patients were subjected to complete hemogram, liver function test, coagulation profile (PT/INR) and USG abdomen. The data was recorded and compiled in excel sheets and analyzed using correlation coefficient (R) method.Results: The mean age of the patients was 41.2 years with male preponderance. Amoebic liver abscess (88%) was predominant over pyogenic liver abscess (12%). Alcoholism (48%), smoking (42%) and diabetes mellitus (18%) are main predisposing factors in case of liver abscess. Hepatomegaly was found in 88% cases. Elevated ALP, low albumin, increased PT INR points to the diagnosis of liver abscess. Complications seen were pleural effusion (10%) and ascites (4%). On analysis, liver abscess size is significantly positively correlated with INR, ALP, liver enzymes, and negatively correlated with serum albumin level.Conclusions: Liver abscess size was found to be positively correlated with INR and alkaline phosphatase (ALP), liver enzymes (SGOT, SGPT) and negatively correlated with serum albumin levels. There was no correlation of abscess size and bilirubin levels. Hence, LFT can be used to estimate the liver abscess size and predict the severity and prognosis of patient.

A Multicenter Retrospective Study on Clinical Characteristics and Outcome of Pyogenic Liver Abscess Focusing Multidrug-Resistant Organisms

“…The increase in serum ALP levels is observed during cholestasis with increased bile acid concentration, due either to liver parenchymal damage or to biliary obstruction Abnormally high ALP level is considered the most reliable and consistent biochemical indicator of PLA. Although in our study, the ALP level had no relationship with the abscess size, previous studies reported that the ALP level was correlated with the abscess volume and disease duration [20,21]. According to a commonly held view, the reason for the prominent elevation in the level of ALP in the MDRO group was assumed to be the fact that the major cause of MDRO-induced PLAs was biliary disease.…”

Zika Virus and Arthritis/Arthralgia: A Systematic Review and Meta-Analysis

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Study on therapeutic effectiveness of laparoscopic drainage and image guided pigtail catheter drainage in the treatment of liver abscess: a randomised controlled trial

“…Jain V et al, in his study on correlation between abscess size and liver function test in cases of liver abscess in the year 2017, stated that abnormally high alkaline phosphatase levels were seen in 94% of cases and hyperbilirubinemia was seen in about 34% of cases. 11 In our study population we noted hyperbilirubinemia in 66.7% of patients, increase in total leukocyte count in 93.3% and raised serum ALP levels in 63.3%.…”