Correlation between a positive family risk score and peripheral artery disease in one case-control and two population-based studies

Lamina, Claudia; Linsenmeyer, Johannes; Weißensteiner, Hansi; Kollerits, Barbara; Meisinger, Christa; Rantner, Barbara; Stöckl, Doris; Stadler, Marietta; Klein-Weigel, Peter; Peters, Annette; Fraedrich, Gustav; Kronenberg, Florian

doi:10.1016/j.atherosclerosis.2014.08.032

Cited by 6 publications

(5 citation statements)

References 35 publications

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“…Family history of diabetes in the KORA F4 Study included information about diabetes for all first-grade relatives and took age of onset into account (18). Variable selection in both adjustment models was based on the Framingham Risk Score for type 2 diabetes (19).…”

Section: Statistical Analyses In All Cohortsmentioning

confidence: 99%

Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals

et al. 2017

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Section: Statistical Analyses In All Cohortsmentioning

confidence: 99%

Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals

et al. 2017

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“…Between February 2004 and May 2005, 3184 individuals participated in the KORA F3 study 28 ; for 3071 individuals, genetic data and family history information was available to obtain the PGS and FamRS. In the follow-up study from 2016, information about morbidity and mortality for 2904 individuals was available (Figure S1).…”

Section: Methodsmentioning

confidence: 99%

“…There was no distinction between different types of stroke. As we described earlier, 28 the expected values for each 10-year age group could be calculated within KORA F3 as this is a population-based study with no specific inclusion criteria other than age range. Taken together, the FamRS basically takes into account the number One early or 2 events at any age within a small or averaged size family would lead to a FamRS of higher than 1.…”

Section: Definition and Calculation Of The Famrsmentioning

confidence: 99%

“…26 Study methods included ascertaining basic sociodemographic information, family and medical history, standardized interviews, and medical examinations. 27 Between February 2004 and May 2005, 3184 individuals participated in the KORA F3 study 28 ; for 3071 individuals, genetic data and family history information was available to obtain the PGS and FamRS. In the follow-up study from 2016, information about morbidity and mortality for 2904 individuals was available (Figure S1).…”

Section: Study Populationmentioning

confidence: 99%

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A Family and a Genome-Wide Polygenic Risk Score Are Independently Associated With Stroke in a Population-Based Study

Hämmerle

Forer

Schönherr³

et al. 2022

Stroke

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BACKGROUND: Positive family history and genetic risk scores have been shown to independently capture those individuals with high risk for stroke. The aim of our study was to evaluate the amount of shared information between family history and genetic risk and to investigate their combined effect on the association with prevalent and incident stroke cases. METHODS: We obtained a family risk score (FamRS), weighted for disease onset and family size as well as genome-wide polygenic risk score (PGS) including over 3.2 million single-nucleotide polymorphisms in the population-based prospective KORA F3 (Cooperative Health Research in the Region of Augsburg) study (n=3071) from Southern Germany. FamRS and PGS were evaluated separately and combined. The measures were once treated as continuous variables but also divided in the highest 20%, 10%, 5%, and 1% percentiles. Odds ratios via logistic regression and hazard ratios via Cox regression were estimated. A stroke event was defined as a hospitalization for stroke that was self-reported in a standardized interview by certified and supervised personnel. RESULTS: The FamRS outperformed other simplified family measures such as affected parents or number of affected family members. FamRS and PGS were not correlated, and no individuals were observed with both very high FamRS and very high PGS (top 1% percentile). In a combined model, both FamRS and PGS were independently from each other associated with risk of stroke, also independent of other traditional risk factors (p [FamRS]=0.02, p [PGS]=0.005). Individuals in the top 1% of either FamRS or PGS were found to have >5-fold risk for stroke (odds ratios, 5.82 [95% CI, 2.08–14]; P =0.0002). The results for incident stroke events showed the same trend but were not significant. CONCLUSIONS: Our study shows that a family risk score and PGS capture different information concerning individual stroke risk. Combining the risk measures FamRS and PGS increases predictive power, as demonstrated in a population-based study.

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“…Intermittent claudication is prevalent in about 3% of individuals aged 40 and prevalence doubles by the age of 60 [2,3]. A number of studies reported an increased risk of cardiovascular and cerebrovascular morbidity and mortality for PAD patients [4][5][6][7]. Besides smoking and diabetes mellitus, dyslipidemia is a common risk factor for PAD and coronary heart disease.…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of serum PCSK9 in male patients with symptomatic peripheral artery disease: The CAVASIC study

et al. 2021

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Correlation between a positive family risk score and peripheral artery disease in one case-control and two population-based studies

Cited by 6 publications

References 35 publications

Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals

Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals

A Family and a Genome-Wide Polygenic Risk Score Are Independently Associated With Stroke in a Population-Based Study

Elevated levels of serum PCSK9 in male patients with symptomatic peripheral artery disease: The CAVASIC study

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