Correlation between a learning disorder and elevated brain-reactive antibodies in aged C57BL/6 and young NZB mice

Nandy, Kalidas; Lal, Harbans; Bennett, Michael; Bennett, Debra A.

doi:10.1016/0024-3205(83)90853-6

Cited by 76 publications

(17 citation statements)

References 12 publications

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“…A correlation has been shown between a raised titre of brainreactive antibodies (BRA) in the serum of the NZBmouse and its behavioural impairment and deficits (as compared to other strains of mice) (Nandy et al 1983). Both behavioural impairment and high titres of antibodies are found at much earlier stages of the NZBmouse as compared to controls (Forster et al 1987;Nandy et al 1983).…”

Section: Introductionmentioning

confidence: 99%

“…Since brain reactive antibodies can occur not only in the NZB-mouse, but also in aging humans and in states of presenile dementia, the NZB-mouse has been suggested as an animal model for human presenile dementia (Nandy et al 1983). Yet, after a search for morphological alterations in the brain of the NZB-mouse, neither a loss of dendritic spines, nor the formation of senile plaques or neurofibrillary deposits could be shown (Nandy et al 1983).…”

Section: Introductionmentioning

confidence: 99%

“…Yet, after a search for morphological alterations in the brain of the NZB-mouse, neither a loss of dendritic spines, nor the formation of senile plaques or neurofibrillary deposits could be shown (Nandy et al 1983). …”

Section: Introductionmentioning

confidence: 99%

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Postnatal development of forebrain regions in the autoimmune NZB-mouse

1991

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NZB-mice are known to have impaired cognitive functions. The aim of the present study is the analysis of the volume growth of different brain regions in NZB/NBOM-mice, because the functional impairment increases postnatally. The regions analysed include brain structures which are important for learning and memory functions. The comparison between NZB-mice and controls (CFW- and Balb/c-mice) shows that the hippocampal volume in NZB-mice is larger than in controls. However, ectopic neurons are found in the dentate gyrus of NZB-mice, indicating a changed connectivity in this region. The septum and the amygdala show no difference in volume in NZB-mice compared to controls. The adult volume of the entorhinal cortex of the NZB-mice is the smallest of the three strains. The development of this brain region is characterized by an overshooting growth in all strains. The caudate-putamen complex and the globus pallidus of NZB-mice undergo a reduction in volume during the postnatal period. This is not found in the controls. An overshooting growth is seen in the mamillary bodies of the three strains, and in the anterior thalamic nucleus of NZB-mice. However, only the NZB-mice show a prolonged reduction of the volume of the mamillary bodies, which is not finished during the observed time period. Both regions are important relay stations in the Papez-circuit, a neuronal system associated with learning and memory functions. The prolonged postnatal reduction in volume of the mamillary bodies and the anterior thalamic nucleus of NZB-mice may be the structural correlate of the impaired cognition and memory in this strain.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Postnatal development of forebrain regions in the autoimmune NZB-mouse

1991

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“…Behavioral deficits have been reported in NZB mice. Nandy et al (17) found that only 1 NZB mouse of 33 could learn a conditioned avoidance response after 70 trials, whereas 33 of 55 C57BL/6 control mice acquired the response in 30 trials or less. NZB mice also are initially less active in the open field (18).…”

Section: Resultsmentioning

confidence: 99%

Cortical anomalies in brains of New Zealand mice: a neuropathologic model of dyslexia?

Sherman¹,

Galaburda²,

Geschwind³

1985

Proc. Natl. Acad. Sci. U.S.A.

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Cortical anomalies have been reported in the brains of dyslexic individuals. In addition, dyslexic and lefthanded individuals have a higher than expected rate of some immune-related diseases. The possible association between immune and cerebrocortical pathology was investigated in the immune-defective New Zealand Black mouse and its hybrid with the New Zealand White mouse. Structural anomalies similar to those present in the dyslexic brain were seen in the brains of these mice. (10,11). The distribution of the lesions in the dyslexic appears to be unique. Therefore, this consistent finding in the brains of dyslexic individuals suggests a meaningful association between the structural anomalies and developmental dyslexia. Geschwind and Behan (12, 13) have reported an association between left-handedness and learning disability and a group ofdiseases involving the immune system. Dyslexia was found to be 10 times more frequent among strongly left-handed than among strongly right-handed subjects, and it occurred more commonly in families of left-handed individuals. Conditions implicating defective immune function (predominantly gut and thyroid disorders) also were significantly more frequent in left-handers and their relatives. An increased incidence of migraine, allergies, attention deficit disorders, and skeletal anomalies were also seen and, more recently, a soluble ribonuclear protein known as Ro antigen, which is present in high concentrations in cardiac and brain tissue, was seen in some mothers of dyslexics (19). These associations may offer useful clues to the etiology of the cerebral anomalies in dyslexia.To address the question of whether a relationship between immune pathology and abnormal brain development exists, we examined the brains of New Zealand Black mice (NZB/BlNJ) and their F1 crosses with New Zealand White mice (NZBWF1/J), strains that spontaneously develop autoimmune disease. The NZB mouse develops hemolytic anemia and the F1 hybrid develops severe renal disease. Both strains are considered models of human systemic lupus erythematosus (14, 15). METHODSWe examined 56 brains from 30-to 90-day-old New Zealand mice: 44 NZB/B1NJ and 12 NZBWF1/J mice. For control comparisons, we studied 59 brains of the Swiss-Webster (CFW) outbred mouse strain, which does not have a history of immune dysfunction. Each group was evenly divided between males and females. After transcardial perfusion with 10% formalin, the brains were embedded in celloidin. They were then coronally sectioned at 30 ,Am, and every 10th section was stained for nerve-cell bodies with cresylechtviolett. Comparisons between control and experimental mice were made with a compound microscope. The cytoarchitecture of the cerebral cortex was examined, and the presence of any abnormalities was noted. RESULTSTen ofthe 56 New Zealand mice had clearcut anomalies in the cerebral cortex, whereas no CFW mouse had any cerebral anomalies (x2 = 9.40; df = 1; P = 0.002; see Table 1). Nine (6 males and 3 females) of the NZB/B1NJ and one female NZBWF1...

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“…This impairment is attributed to learning and/or memory deficits. NZB mice, therefore, could be a suitable animal model for human dementia (Spencer, in press;Nandy, 1983).…”

Section: Introductionmentioning

confidence: 99%

Quantitative and cytoarchitectural studies of the entorhinal region and the hippocampus of New Zealand Black mice

Anstätt¹

1988

J. Neural Transmission

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New Zealand Black (NZB) mice were suggested as an animal model for human dementia. We performed quantitative and cytoarchitectural studies of the entorhinal region and the hippocampus of 10 NZB mice and compared the results with those for a control group of 10 Carworth Farm Webster (CFW) mice. No cytoarchitectural disturbances were observed in the entorhinal cortex and hippocampus of the NZB mice. We, however, found a reduced density of nerve cells in the entorhinal region as well as in the CA1 and CA3 regions of the Ammon's horn in NZB mice. Since the entorhinal region is an important link between sensory and association cortices and the limbic system which seems to play an important role in learning and memory, the present findings may be a cause of learning and/or memory deficits in the NZB mice. The undisturbed cytoachitecture of the entorhinal cortex suggests that the reduced cell sensity in NZB mice is rather an acquired lesion than a developmental malformation and, therefore, indicates therapeutic studies on memory and learning deficits in NZB mice.

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Correlation between a learning disorder and elevated brain-reactive antibodies in aged C57BL/6 and young NZB mice

Cited by 76 publications

References 12 publications

Postnatal development of forebrain regions in the autoimmune NZB-mouse

Postnatal development of forebrain regions in the autoimmune NZB-mouse

Cortical anomalies in brains of New Zealand mice: a neuropathologic model of dyslexia?

Quantitative and cytoarchitectural studies of the entorhinal region and the hippocampus of New Zealand Black mice

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