Correlation analysis on 3D data – Introducing the alteration analysis

The use of alteration analysis in supercritical fluid chromatography to monitor changes in a series of chromatograms

“…This experiment was designed simply to employ the theoretical properties of ALA -described in our previous studies [18,20] -in practice. A series of SFC measurements were executed with seven compounds present in the sample and their concentration was changed according to different functions from sample to sample (Fig.…”

“…We still believe, however, that the benefits of this method can be advantageous in chromatography and thus we introduced ALA, which includes the basic properties of 2DCOR, but has more emphasis on individual changes. It was first introduced to extend the boundaries of 2DCOR to three-dimensional data sets compiled from a series of two-dimensional measurements [18]. 2DCOR can already deal with 3D data, but what we propose is somewhat different, because the third dimension is another perturbation [19], so the allocation of dimensions is as follows: 1st -1D measurement, 2nd -perturbation, 3rd -another perturbation.…”