Correlation analysis of flow parameters in the olfactory cleft and olfactory function

Wu, Shuo; Wang, Pei-ji; Xie, Dielai; Jian, Feitong

doi:10.1038/s41598-022-25282-3

Cited by 3 publications

(1 citation statement)

References 21 publications

(21 reference statements)

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“…However, our sample was comprised of healthy individuals and it is possible that this relationship between olfaction and airflow was not clearly depicted in this population. Also, although a relationship between olfaction and airflow through the olfactory cleft has been mentioned previously in literature [ 62 , 63 ], PNIF measures airflow through the entire nasal cavity and not only to the olfactory cleft on maximal inspiration, and may also be confounded by the influence of lung function. For these reasons, we may not have observed a correlation between the two tests.…”

Section: Discussionmentioning

confidence: 99%

Correlations between gustatory, trigeminal, and olfactory functions and nasal airflow

Hernandez

Walke

Haehner

et al. 2023

Eur Arch Otorhinolaryngol

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Purpose To determine the relationship of chemosensory screening and nasal airflow tests among the same set of participants, and to determine other factors that are related to the outcomes of these tests. Methods Participants had no chemosensory complaints. Structured medical history was taken. Participants underwent 5 screening tests: q-sticks (orthonasal olfaction), q-powders (retronasal olfaction), trigeminal lateralization test, taste sprays, and peak nasal inspiratory flow (PNIF). Ratings of smell/taste ability and nasal airflow were obtained using visual analogue scales (VAS). Composite sinusitis symptoms and significance of olfaction questionnaire scores were also determined. Results Four hundred participants were included in the study, 156 men, 244 women; aged 18–82 years (mean: 46). The q-powders and taste spray scores were weakly positively correlated with all the other chemosensory tests and PNIF. However, chemosensory test scores were not correlated with VAS, composite sinusitis symptoms, and significance of olfaction questionnaire scores. Various tests showed significant decrease starting at specific ages (in years, PNIF and trigeminal lateralization: 40, q-powders: 60, and q-sticks: 70). Conclusion Chemosensory screening tests and self-rated chemosensory function showed no correlation in participants without chemosensory complaints. In addition, gustatory function appeared to be correlated with olfactory and trigeminal function but also with nasal airflow, and nasal airflow was related not only to olfactory but also to trigeminal and taste function. Over all, the results suggest that chemosensory functions (orthonasal olfactory, trigeminal, retronasal olfactory, gustatory) and nasal airflow are correlated with each other, which we propose may be possibly mediated, at least in part, through central nervous system interactions.

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Section: Discussionmentioning

confidence: 99%

Correlations between gustatory, trigeminal, and olfactory functions and nasal airflow

Hernandez

Walke

Haehner

et al. 2023

Eur Arch Otorhinolaryngol

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Olfactory cleft stenosis and obstruction on paranasal sinus CT scan in pre-septo-rhinoplasty patients: normal variants or pathologic findings?

Imbs,

Deyrail,

Nguyen

et al. 2024

Eur Radiol

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The Human Nose as a Chemical Sensor in the Perception of Coffee Aroma: Individual Variability

2023

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The flavor of foods and beverages is generally composed of a mixture of volatile compounds, however not all the molecules that form an aroma are sensorially relevant. The odor-active compounds present in a mixture are different for each subject, both in quantitative and qualitative terms. This means that the ability of the human nose to act as a chemical sensor varies among individuals. In this study, we used the headspace of roasted coffee beans as a complex olfactory stimulus and, by means of the coupled Gas Chromatography-Olfactometry (GC-O) technique, the single components of coffee flavor were separated. Each subject, previously classified for his/her olfactory status (normosmic, hyposmic or anosmic) by means of the Sniffin’ Sticks battery (composed of Threshold, Discrimination and Identification subtests), had to identify and evaluate each smelled molecule. The results show that the individual ability to detect individual compounds during the GC-O experiments and the odor intensity reported during the sniffing of pen #10 (the pen of the identification test) containing coffee aroma were related to TDI olfactory status (based on the score obtained from the sum composed of Threshold, Discrimination and Identification scores). We also found that the number of total molecules and of molecules smelling of coffee is linearly related to the TDI olfactory score. Finally, the odor intensity reported when sniffing pen #10 containing coffee aroma is positively correlated with the number of molecules detected and the average intensity reported. In conclusion, our findings show that the human perception of both individual compounds and complex odors is strongly conditioned by the olfactory function of subjects.

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Correlation analysis of flow parameters in the olfactory cleft and olfactory function

Cited by 3 publications

References 21 publications

Correlations between gustatory, trigeminal, and olfactory functions and nasal airflow

Correlations between gustatory, trigeminal, and olfactory functions and nasal airflow

Olfactory cleft stenosis and obstruction on paranasal sinus CT scan in pre-septo-rhinoplasty patients: normal variants or pathologic findings?

The Human Nose as a Chemical Sensor in the Perception of Coffee Aroma: Individual Variability

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