2022
DOI: 10.3389/fendo.2022.1027430
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Correlation analysis of carotid artery intima-media thickness, serum 25(OH)D and men with erectile dysfunction

Abstract: Our goal is to investigate the connection between serum 25(OH)D and carotid artery intima-media thickness (CIMT) in men with erectile dysfunction (ED).Serum 25(OH)D and CIMT were measured in 124 participants with erectile dysfunction and 39 healthy controls. The relationship between them and different patient-related parameters and disease-related parameters was studied. Compared with the control group and mild ED group, the level of serum 25(OH)D in moderate ED group and severe ED group decreased significantl… Show more

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Cited by 6 publications
(4 citation statements)
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“… 30 Zhang et al showed that CIMT was significantly higher in ED groups, especially among patients with severe ED, and that CIMT was negatively correlated with the IIEF-5 score. 31 Bocchio et al emphasized that in men without clinical signs of vascular disease, the severity of ED determined by IIEF-5 correlated with CIMT and that CIMT could be used to predict severe ED. 10 In another study, it was shown that there was a positive linear relationship between the degree of ED and the thickness of the carotid intima media.…”
Section: Discussionmentioning
confidence: 99%
“… 30 Zhang et al showed that CIMT was significantly higher in ED groups, especially among patients with severe ED, and that CIMT was negatively correlated with the IIEF-5 score. 31 Bocchio et al emphasized that in men without clinical signs of vascular disease, the severity of ED determined by IIEF-5 correlated with CIMT and that CIMT could be used to predict severe ED. 10 In another study, it was shown that there was a positive linear relationship between the degree of ED and the thickness of the carotid intima media.…”
Section: Discussionmentioning
confidence: 99%
“…Consequently, a study of 100 men (50 with acute myocardial infarction (MI) and 50 age-matched healthy controls) observed that FMD and vitamin D levels were markedly reduced in patients with MI compared with controls. Furthermore, the results of this study showed the presence of a positive correlation between vitamin D levels and FMD [ 43 ]. Another double-blind randomized clinical study of 44 hypertensive and type 2 diabetic patients divided into two groups, with 23 patients treated with 2000 IU of cholecalciferol daily for 12 weeks and 21 with placebo for 12 weeks, showed that FMD increased significantly in the vitamin D-treated group.…”
Section: Vitamin D and Endothelial Functionmentioning
confidence: 96%
“…Other evidence in favor of the role of vitamin D on endothelial function comes from studies that evaluated its relationship with other markers of endothelial health, such as carotid artery intima–media thickness (CIMT) [ 41 ], ankle–brachial index [ 42 ], and flow-mediated dilation (FMD) [ 43 ]. The latter is closely linked to endothelial function and is significantly reduced in patients affected by vascular diseases [ 43 ].…”
Section: Vitamin D and Endothelial Functionmentioning
confidence: 99%
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