Correlation analysis between the SUVmax of FDG-PET/CT and clinicopathological characteristics in oral squamous cell carcinoma

Abstract

Objectives: To investigate the relationship between maximum standardized uptake value (SUVmax) of 18F-FDG PET/CT and clinicopathological features of oral squamous cell carcinoma (OSCC), in order to formulate a better clinical guideline. Methods: In 104 patients with OSCC confirmed by pathology, there were 67 males and 37 females (age, 33–76 years; mean age, 56 years).18FDG, 18-fludeoxyglucose (18F-FDG) PET/CT manifestations and the clinicopathological features of the 104 patients were retrospectively analysed. Single-factor analysis and multiple regression analysis were conducted on possible factors influencing primary tumour SUVmax, including gender, age, smoking history, tumour location, tumour size, histological differentiation, TNM stage, T stage, N stage. Diagnostic performance of SUVmax for invading peri-tissue of OSCC was measured by the area under receiver operating characteristic curve, and sensitivity and specificity were determined at the Youdons index. Results: The single-analysis results showed that SUVmax was correlated with the histological differentiation, tumour size, TNM stage, T stage, N stage(p < 0.05), yet it was not correlated with gender, age, smoking history, tumour location (p > 0.05). Multivariate liner regression analysis showed that tumour size, TNM stage were influencing factors independent of primary tumour SUVmax (p < 0.05). Primary tumour SUVmax had predictive value for invading peri-tissue of OSCC. When the cutoff value was 7.98, the diagnostic efficiency was the highest, with the sensitivity being 90.0％ and the specificity being 76.2%. Conclusions: OSCC 18F-FDG PET/CT SUVmax is higher among patients with larger tumour size, poorer stage, and that primary tumour SUVmax is of important significance in predicting invading peri-tissue.

Implications of Standardized Uptake Values of Oral Squamous Cell Carcinoma in PET-CT on Prognosis, Tumor Characteristics and Mitochondrial DNA Heteroplasmy

“…Correlation analysis demonstrated significant association between SUVmax and grading as well as UICC. These results indicate a dependency between the local metabolic activity of tumors as seen by PET-CT and histopathological characteristics of the tumor, which are consistent with previous results [35]. According to Stalder et al [52], we also found a strong relationship between SUVmax and the presence of bone infiltration in our study collective [52].…”

“…Studies on different tumor entities confirmed the feasibility to assign a predictive value to this metabolic activity quantified by the SUVmax, measured in 18 [F]FDG PET and PET-CT. The method has shown to represent a valid marker for prognosis, recurrence and survival time [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. Berghmans et al also highlighted this connection early in their review of the predictive value of SUVmax on survival times in patients with non-small-cell lung cancer (NSCLC) and identified a survival-dependent threshold for SUVmax [ 44 ].…”

Relationships Between DCE-MRI, DWI, and ¹⁸F-FDG PET/CT Parameters with Tumor Grade and Stage in Patients with Head and Neck Squamous Cell Carcinoma

“…Although Leifels et al ( 3 ) did not observe significant differences in SUV max between various T and N stages, Nakajo et al ( 16 ) reported significantly higher SUV max values in T3 and T4 tumors. In a previous study, T4 tumors had significantly higher SUV max values than T1-3 tumors in patients with oral squamous cell carcinoma ( 27 ). In our study, we observed higher MTV (40% threshold) values in T4 tumors than T1-3 tumors.…”

“…Choi et al ( 34 ) and Nakajo et al ( 16 ) also found no association between SUV max and ADC with grade. Zheng et al ( 27 ) analyzed 104 patients with oral SCC and observed an association between SUV max and poor differentiation. Different grading systems in HNSCC include parameters such as lymphoplasmacytic infiltration, keratinization degree of the tumor, nuclear and cellular polymorphism, and invasion pattern ( 35 ).…”

Clinical Significance and Prognostic Value of the Maximum Standardized Uptake Value of 18F-Flurodeoxyglucose Positron Emission Tomography–Computed Tomography in Colorectal Cancer

“…As one of the important parameters of 18 F-FDG PET/CT, the SUVmax is able to measure the activity of tissue metabolism, which is strongly correlated with cell division and proliferation (49). Thus, the SUVmax is considered to sensitively predict the biological behavior of tumors that is influenced by various clinical factors (50).…”