Correlation Analysis between Intraocular Pressure and Extraocular Muscles Based on Orbital Magnetic Resonance T2 Mapping in Thyroid-Associated Ophthalmopathy Patients

Luo, Ban; Wang, Wei; Li, Xinyu; Zhang, Hong; Zhang, Yaoli; Hu, Wei

doi:10.3390/jcm11143981

Cited by 2 publications

(3 citation statements)

References 22 publications

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“…The current opinion is that IOP increase is mostly due to orbital edema, which consists of the increased production of GAGs by the orbital fibroblasts, and inflammation-activated fibroblasts differentiating into adipocytes ( 19 ). A recent study used T2RT, which reflects the edema changes caused by autoimmune inflammation and vascular congestion, and found that the high IOP in patients with TAO was positively correlated with EOM inflammation ( 13 ). This is consistent with our finding of a significant increase of EOM volume in the MRI T2 phase.…”

Section: Discussionmentioning

confidence: 99%

“…Proptosis, orbit enlargement, EOM proliferation, and OF expansion can be measured using orbital MRI and subsequently resolved ( 11 ). However, most of the existing studies have focused on the clinical features of orbital tissue in TAO, such as quantitation of EOM fibrosis by T1 mapping and T2 relaxation time (T2RT) ( 12 , 13 ), and the relationship between IOP and orbital tissue remains unexplored in comparison.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of extraocular muscles for intraocular pressure in thyroid-associated ophthalmopathy patients

Tian,

Wang,

et al. 2023

Quant Imaging Med Surg

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Background Persistent increase in intraocular pressure (IOP) is often observed in eyes with thyroid-associated ophthalmopathy (TAO), which has irreversible effects on the visual function of patients. This retrospective cross-sectional study evaluated the value of magnetic resonance imaging (MRI) measurements of extraocular muscle (EOM) volume in prognosing IOP in patients with TAO. Methods This single-center study was conducted in Beijing Friendship Hospital (Beijing, China), a tertiary hospital. From 35 participants, 70 eyes (normal IOP group: 50 eyes; high IOP group: 20 eyes; random samples) were enrolled in this study. Basic data from patients were collected and compared using 2-sample t- tests and chi-squared tests. The volume of the EOM, orbit fat, and whole orbit were measured by orbital MRI. Moreover, proptosis, optic nerve (ON) sheath diameter, optic nerve angle (ONA), and gaze angle were additionally measured with MRI. These parameters were compared between the two groups using 2-sample t- tests and chi-squared tests. Before and after post-methylprednisolone therapy, the MRI data of 20 eyes were obtained and compared with a paired t- test. Peripapillary retinal nerve fiber layer (RNFL) thickness was obtained using an optical coherence tomography (OCT) scan. Spearman rank correlation analysis, logistic regression analysis, and receiver operating characteristic (ROC) curves were performed to evaluate the role of these factors in IOP changes. Results The EOM volume and axial and sagittal ONAs in the high-IOP group were significantly increased compared to the normal-IOP group (P<0.001, P=0.001, P=0.02, respectively). Logistic regression analysis indicate that the cutoff value for EOM volume for the diagnosis of high IOP was significantly larger than that of the other parameters except orbit volume (P=0.03, P=0.004, P=0.08, respectively). Spearman correlation analysis revealed a significant correlation between EOM volume and ON sheath diameter and average RNFL thickness (P=0.01, P=0.02, respectively). A paired t- test indicated a significant decrease of EOM volume and ON sheath diameter as well as a significant enlargement of the axial ONAs after methylprednisolone therapy (P=0.002, P=0.02, P=0.05, respectively). Conclusions EOM volume was an effective diagnostic factor for tracking IOP changes and ON patterns in patients with TAO. Methylprednisolone therapy is recommended for patients with TAO with secondary glaucoma to quickly reduce the EOM volume.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prognostic value of extraocular muscles for intraocular pressure in thyroid-associated ophthalmopathy patients

Tian,

Wang,

et al. 2023

Quant Imaging Med Surg

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“…It has been reported that as IOP increases, the trabecular meshwork expands toward the SC lumen and concurrently causes the narrowing of the lumen [ 23 ]. Moreover, several studies have observed IOP elevation in GO eyes [ 6 , 24 ]. Elevated IOP in healthy individuals has also been shown to decrease the cross-sectional area of SC [ 25 , 26 ].…”

Section: Dıscussıonmentioning

confidence: 99%

Assessment of Schlemm’s canal with swept-source optical coherence tomography in Graves’ ophthalmopathy

Gün,

Yazıcıoğlu,

Oklar

et al. 2024

Graefes Arch Clin Exp Ophthalmol

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Purpose To evaluate the Schlemm’s canal (SC) parameters obtained by swept-source optical coherence tomography (OCT) different in Graves’ ophthalmopathy (GO) eyes compared to healthy eyes. Methods This cross-sectional observational study evaluated 64 eyes of 32 GO cases and 56 eyes of 28 healthy controls. The study was conducted between October 2020 and June 2021. SC images were obtained from the temporal limbus of individuals using swept-source OCT. SC length (SCL) and SC area (SCA) were measured. The relationship between SC parameters in the patient group and intraocular pressure (IOP), retinal nerve fiber layer (RNFL) thickness, Graves’ disease (GD) duration, and clinical activity score (CAS) was evaluated. Results In the GO group, 64 eyes of 32 patients were evaluated, and in the age and gender-matched healthy control group, 56 eyes of 28 individuals were assessed. SC images from 4 eyes of 4 patients in the patient group and 1 eye of 1 patient in the control group were not clear, preventing SCL and SCA measurements for these eyes. SCL and SCA measurements were found to be lower, and IOP and Hertel values were higher in the GO group compared to the healthy controls. However, no significant correlation was observed between SCL and SCA with IOP, RNFL thickness, GD duration, GO duration, or CAS in the GO group. In the GO group, the mean value of SCA was found to be higher in eyes with glaucoma or OHT compared to those without. Conclusion These findings indicate that SC in GO-affected eyes is shorter and has a smaller area than in healthy individuals. Additionally, higher IOP and Hertel values were observed in the GO group compared to healthy controls. This study suggests that assessing SC using anterior segment OCT could provide valuable insights into the regulation of IOP and the development of glaucoma in GO-affected eyes.

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Correlation Analysis between Intraocular Pressure and Extraocular Muscles Based on Orbital Magnetic Resonance T2 Mapping in Thyroid-Associated Ophthalmopathy Patients

Cited by 2 publications

References 22 publications

Prognostic value of extraocular muscles for intraocular pressure in thyroid-associated ophthalmopathy patients

Prognostic value of extraocular muscles for intraocular pressure in thyroid-associated ophthalmopathy patients

Assessment of Schlemm’s canal with swept-source optical coherence tomography in Graves’ ophthalmopathy

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