Correlating Differences in the Surface Activity to Interface-Induced Particle Formation in Different Protein Modalities: IgG mAb Versus Fc-Fusion Protein
Valerie P. Griffin,
Estephanie L. N. Escobar,
Maria O. Ogunyankin
et al.
Abstract:The propensity of protein-based biologics to form protein
particles
during bioprocessing can be related to their interfacial properties.
In this study, we compare the surface activity and interfacial film
properties of two structurally different biologics, an IgG and Fc-fusion,
in the absence and presence of interfacial dilatational stresses,
and correlate these differences to their tendency to form interface-induced
protein particles. Our results show that interface-induced particle
formation is protein-depen… Show more
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