Correlating Biochemical and Hematological Parameters in Patients With Dengue

Abstract

Objectives: The objectives of this study were to ascertain the correlation of the various biochemical and hematological parameters to dengue positive status. Methods: Based on review of literature, we calculated the correlation of biochemical and hematological parameters of liver profile in dengue positive and dengue negative patients in a convenience sampling of 140 dengue negative and 49 dengue positive cases. Results: Total bilirubin (TBI), total plasma protein, globulin, and alkaline phosphatase showed inverse correlation to dengue positive status, while albumin/globulin ratio elicited direct correlation. (p˂0.05) Other parameters, namely, random blood sugar, direct bilirubin, indirect bilirubin, albumin, SGPT, and SGOT showed no clear cut correlation with dengue positive or negative status (p>0.05). Conclusions: TBI, total plasma protein, globulin and alkaline phosphatase, and albumin/globulin ratio should be ascertained in a large equal group-size randomized study to establish their authenticity as prognosticators of the disease.