Correlates of response to Olanzapine in a North Indian Schizophrenia sample

Thomas, Pramod; Srivastava, Vibhuti; Singh, Anuradha; Mathur, Priya; Nimgaonkar, Vishwajit L.; Lerer, Bernard; Thelma, B.K.; Deshpande, Smita N.

doi:10.1016/j.psychres.2007.09.010

Cited by 27 publications

(15 citation statements)

References 40 publications

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“…However, a meta-analysis showed a trend that confirmed the previous finding of the association of homozygosity for C allele and nonresponse [13] . The T102C polymorphism was also associated with classical neuroleptic response [30] and risperidone [15] , as well as olanzapine [16,31,32] response. Interestingly, in the study of Lane et al [15] , the C/C genotype was related to better clinical performance than the T/C or T/T genotype in terms of the total PANSS score, and negative and general psychopathology subscale scores of the PANSS, but not in terms of the positive subscale scores.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of the 5-HT2A Receptor Gene and Clinical Response to Olanzapine in Paranoid Schizophrenia

Olajossy-Hilkesberger

Godlewska

Schosser-Haupt

et al. 2011

Neuropsychobiology

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Background: 5-HT2A receptor is strongly implicated in the mode of action of atypical antipsychotic drugs. The aim of the study was to investigate whether the 5-HT2A receptor gene’s polymorphisms (His452Tyr and T102C) have an influence on the response to olanzapine in patients with schizophrenia. Methods: We studied 99 Caucasian schizophrenia patients treated with olanzapine. Psychopathology was measured before and after 6 weeks of treatment. Clinical improvement was quantified as change in Positive and Negative Syndrome Scale (PANSS) total scores and subscores as shown by percentage improvement below the baseline score. The clinical response to antipsychotic treatment was defined as 30% improvement from baseline in PANSS scores. Results: The His/Tyr polymorphism was significantly associated with a percentage improvement in PANSS positive symptom subscore (better response in His/His homozygotes; p < 0.05) after treatment with olanzapine. As for the T102C polymorphism, a better response in terms of PANSS positive subscore improvement was observed for C/C homozygotes (p < 0.01). A significant association of 5-HT2A genotype distribution of the T102C polymorphism with a categorical measure of response, but only in terms of PANSS positive symptom subscores, was observed (p < 0.01). Conclusions: Variations in the 5-HT2A receptor gene may influence individual and particularly positive symptom response to olanzapine.

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Section: Discussionmentioning

confidence: 99%

Polymorphisms of the 5-HT2A Receptor Gene and Clinical Response to Olanzapine in Paranoid Schizophrenia

Olajossy-Hilkesberger

Godlewska

Schosser-Haupt

et al. 2011

Neuropsychobiology

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“…While the first study to evaluate DRD1 and treatment response suggested that rs4532 (48A/G, recognized by a DdeI restriction cut site) was associated with clozapine response (Potkin et al, 2003), following evidence presented only a trend towards association in European-and AfricanAmerican subjects (Hwang et al, 2007). Three other studies have presented mixed results indicating significant association with clozapine (Ota et al, 2012), but not with olanzapine (Thomas et al, 2008) or risperidone (Huo et al, 2015) response. Most of the studies have small sample sizes, methodological differences and conflicting results that inhibit their use in the clinical practice (Zhang et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Meta-analysis of dopamine receptor D1 rs4532 polymorphism and susceptibility to antipsychotic treatment response

Matos

Santana

Souza

2015

Psychiatry Research

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“…Thomas et al . [58] analyzed the response and side-effects of Olanzapine in Indian subjects compared to genetic differences in patients. Ten polymorphic markers from seven genes (dopamine D1, D2, D3 and D4 receptors, serotonin 2A receptor and the drug-metabolizing enzymes (CYP1A2 and CYP2D6) are analyzed as potential predictors of response.…”

Section: Introductionmentioning

confidence: 99%

Molecular biology research in neuropsychiatry: India′s contribution

Rao

Ramesh

Padmaraju

et al. 2010

Indian J Psychiatry

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Neuropsychiatric disorders represent the second largest cause of morbidity worldwide. These disorders have complex etiology and patho-physiology. The major lacunae in the biology of the psychiatric disorders include genomics, biomarkers and drug discovery, for the early detection of the disease, and have great application in the clinical management of disease. Indian psychiatrists and scientists played a significant role in filling the gaps. The present annotation provides in depth information related to research contributions on the molecular biology research in neuropsychiatric disorders in India. There is a great need for further research in this direction as to understand the genetic association of the neuropsychiatric disorders; molecular biology has a tremendous role to play. The alterations in gene expression are implicated in the pathogenesis of several neuropsychiatric disorders, including drug addiction and depression. The development of transgenic neuropsychiatric animal models is of great thrust areas. No studies from India in this direction. Biomarkers in neuropsychiatric disorders are of great help to the clinicians for the early diagnosis of the disorders. The studies related to gene-environment interactions, DNA instability, oxidative stress are less studied in neuropsychiatric disorders and making efforts in this direction will lead to pioneers in these areas of research in India. In conclusion, we provided an insight for future research direction in molecular understanding of neuropsychiatry disorders.

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Correlates of response to Olanzapine in a North Indian Schizophrenia sample

Cited by 27 publications

References 40 publications

Polymorphisms of the 5-HT2A Receptor Gene and Clinical Response to Olanzapine in Paranoid Schizophrenia

Polymorphisms of the 5-HT2A Receptor Gene and Clinical Response to Olanzapine in Paranoid Schizophrenia

Meta-analysis of dopamine receptor D1 rs4532 polymorphism and susceptibility to antipsychotic treatment response

Molecular biology research in neuropsychiatry: India′s contribution

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