Correlates of Pain Intensity in Men and Women With Hip and Knee Osteoarthritis. Results of a National Survey: The French ARTHRIX Study

Perrot, Serge; Poiraudeau, Serge; Kabir-Ahmadi, Marmar; Rannou, François

doi:10.1097/ajp.0b013e3181b43d4f

Cited by 55 publications

(43 citation statements)

References 24 publications

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“…In humans, pain at rest and during movement were also shown to respond differently to different analgesics (27,28). In the context of OA, pain on movement is often more severe than pain at rest (25,29), correlates inversely with physical function, and has an earlier M A N U S C R I P T…”

Section: Discussionmentioning

confidence: 98%

Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain

Leung

Huebner

Haaland

et al. 2017

Osteoarthritis and Cartilage

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Section: Discussionmentioning

confidence: 98%

Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain

Leung

Huebner

Haaland

et al. 2017

Osteoarthritis and Cartilage

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“…It has therefore been argued that the assessment of acute postoperative pain‐on‐movement is more important than assessing pain‐at‐rest because of the potential for interference with postoperative mobilization 10. In the context of OA, pain‐on‐movement is often more severe than pain‐at‐rest 11 and has an earlier onset in the disease course. However, the mediating pathways between preoperative, acute postoperative, and chronic postoperative pain‐at‐rest and pain‐on‐movement remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Rest Pain and Movement‐Evoked Pain as Unique Constructs in Hip and Knee Replacements

Sayers

Wylde

Lenguerrand

et al. 2016

Arthritis Care & Research

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ObjectiveThere is limited information about the extent to which the association between preoperative and chronic postoperative pain is mediated via pain‐on‐movement or pain‐at‐rest. We explored these associations in patients undergoing total hip replacement (THR) and total knee replacement (TKR).MethodsA total of 322 and 316 patients receiving THR and TKR, respectively, were recruited into a single‐center UK cohort (Arthroplasty Pain Experience) study. Preoperative, acute postoperative, and 12‐month pain severity was measured using self‐reported pain instruments. The association between preoperative/acute pain and chronic postoperative pain was investigated using structural equation modeling (SEM).ResultsPatients with high levels of preoperative pain were more likely to report chronic pain after THR (β = 0.195, P = 0.02) and TKR (β = 0.749, P < 0.0001). Acute postoperative pain‐on‐movement was not associated with chronic pain after TKR or THR after adjusting for preoperative pain; however, acute pain‐at‐rest was associated with chronic pain after THR (β = 0.20, P < 0.0002) but not TKR after adjusting for preoperative pain. Analysis of pain‐at‐rest and pain‐on‐movement highlighted differences between THR and TKR patients. Chronic pain‐at‐rest after THR was weakly associated with pain‐at‐rest during the preoperative (β = 0.11, P = 0.068) and acute postoperative period (β = 0.21, P < 0.0001). In contrast, chronic pain‐on‐movement after TKR was strongly associated with the severity of pain‐on‐movement during the preoperative period (β = 0.51, P = 0.001).ConclusionSEM illustrated the different patterns of association between measures of pain over time in patients undergoing THR and TKR for osteoarthritis. These findings highlight the importance of future work that explores the mechanisms underlying pain‐on‐movement and pain‐at‐rest.

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“…2) and is often influenced by psychosocial conditions. Factors underlying OA such as psychosocial factors, mood and coping can influence pain severity, and should be considered in the light of age, gender, anatomical site, body mass index (BMI), comorbidities, educational level, and other psychological factors (75,76).…”

Section: N Constitutional and Bio-psychosocial Factors Of Osteoarthrimentioning

confidence: 99%

The sources of pain in osteoarthritis: a pathophysiological review

2014

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summaryThe pain of osteoarthritis (OA) has multifaceted etiologies within and outside the joint. It is believed to be driven by both nociceptive and neuropathic mechanisms, as well as abnormal excitability in the pain pathways of the peripheral and central nervous system. Inflammation in the joint triggers a cascade of events that leads to peripheral sensitization, increased sensitivity of nociceptive primary afferent neurons, and hyperexcitability of the nociceptive neurons in the central nervous system. Pain receptors have been found in the synovium, ligaments, capsule, subchondral bone and surrounding tissues, with the exception of articular cartilage. The bone-related causes of pain in OA include subchondral microfractures, bone stretching with elevation of the periosteum due to osteophyte growth, bone remodeling and repair, bone marrow lesions, and bone angina caused by decreased blood flow and increased intra-osseous pressure. Central factors alter pain processing by setting the gain in such a way that, when a peripheral input is present, it is processed against a background of central factors that can enhance or diminish the experience of pain. As a complex phenomenon with a strong subjective component, pain can also be influenced by the nature of the underlying disease, personal predisposition (biological and psychological), and environmental and psychosocial factors. This review examines the current literature regarding the sources and mechanisms of pain in OA.

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Correlates of Pain Intensity in Men and Women With Hip and Knee Osteoarthritis. Results of a National Survey: The French ARTHRIX Study

Abstract: Pain intensity ratings for patients with lower limb OA differed significantly with respect to sex, age, body mass index, physical activity, professional activity, marital status, and conditions of assessment.

Cited by 55 publications

References 24 publications

Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain

Synovial fluid pro-inflammatory profile differs according to the characteristics of knee pain

Rest Pain and Movement‐Evoked Pain as Unique Constructs in Hip and Knee Replacements

The sources of pain in osteoarthritis: a pathophysiological review

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