Whether these premature deaths are preventable is a critical question. With respect to substance use disorders, the risk of premature death varies by many possible factors, including type of drug, severity of use, trajectory of drug use, co-occurring psychiatric illness, and other personal characteristics, including age, gender, race socioeconomic status, health status, or health behaviors, including tobacco and alcohol use (Bargagli et al., 2006; Kertesz et al., 2012; Smyth, Fan, & Hser, 2006). Some of these factors are not modifiable (e.g., age), or are very difficult to modify (e.g., socioeconomic status), whereas others such as drug use severity are potentially modifiable. The purpose of this article is to examine the association between drug use severity and mortality as well as cause of death in primary care patients with substance use disorders. The motivation for conducting this analysis stems from the idea that if there were an association, then intervening to reduce severity could result in lower rates of premature death.