Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults

Amat, José; Bansal, Ravi; Whiteman, Ronald C.; Haggerty, Rita; Royal, Jason; Peterson, Bradley S.

doi:10.1016/j.bandc.2007.05.009

Cited by 45 publications

(38 citation statements)

References 79 publications

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“…It has been also described that cytoarchitectonic differences in primary visual cortex may underlie observed sex differences in the processing of visuospatial and motion information (Amunts et al, 2007). Amat et al (2008) found a significant inverse correlation between intellectual abilities and hippocampus volume which was independent of sex.…”

Section: Introductionmentioning

confidence: 78%

Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: The effect on cognitive functioning

Crespo‐Facorro

Roiz-Santiáñez

Pérez-Iglesias

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Previous investigations have revealed sex-specific differences in brain morphometry. The effect of sex on cortical thickness may be influencing cognitive differences between sexes. With this exploratory study, we aimed to investigate the effect of sex in MRI-based cerebral cortex morphometry in healthy young volunteers and how the variability in cortical measures might affect cognitive functioning in men and women. 76 young healthy volunteers (45 men and 31 women) underwent a 1.5 T MR scan and 53 of them completed a comprehensive cognitive battery. Overall no gross significant differences between sexes were found in cortical thickness, surface area and curvature indexes. However, there was a significant group by hemisphere interaction in the total cortical thickness (F(1,72)=5.02; p=0.03). A greater leftward asymmetry was observed in cortical thickness in males. Only females show significant associations between cortical thickness and cognitive functioning (IQ and executive functioning). In conclusion, our findings do not support the notion of sexual dimorphism in cortical mantle morphology. The results also suggest that variability in cortical thickness may affect cognitive functioning in females but not in males.

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Section: Introductionmentioning

confidence: 78%

Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: The effect on cognitive functioning

Crespo‐Facorro

Roiz-Santiáñez

Pérez-Iglesias

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

View full text Add to dashboard Cite

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“…However, a correlation between IQ and amygdala volume did not reveal any significant associations, consistent with previously reported findings in healthy adults. 62 Fourth, clinical outcome measures revealed that by 12 months many of the adolescents with bipolar disorder who began the study manic were euthymic (Table 1). Associations revealed a significant correlation between baseline YMRS scores and amygdala volume in the bipolar group; however no correlation was found between 12 month YMRS scores and amygdala volume.…”

Section: Discussionmentioning

confidence: 99%

Progression of Amygdala Volumetric Abnormalities in Adolescents After Their First Manic Episode

Bitter

Mills

Adler

et al. 2011

Journal of the American Academy of Child & Adolescent Psych

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Objective Although previous neuroimaging studies suggest that adolescents with bipolar disorder exhibit smaller amygdala volumes compared with healthy adolescents, whether these abnormalities are present at illness onset or instead develop over time remains unclear. The aim of this study was to conduct a prospective longitudinal investigation comparing amygdala neurodevelopment among adolescents following their first manic episode, adolescents with attention deficit hyperactivity disorder (ADHD), and healthy adolescents. Method Thirty adolescents hospitalized for their first manic/mixed episode associated with bipolar disorder, twenty-nine adolescents with ADHD, and twenty-four demographically matched healthy teens underwent magnetic resonance imaging scans at index assessment and approximately 12 months later. Adolescents with bipolar disorder were prospectively evaluated using diagnostic interviews and symptom rating scales. Results Mixed models examining group-by-time effects for both left (p=0.005) and right (p=0.002) amygdala volumes were statistically significant. Change in left (p=0.01) and right (p=0.0008) amygdala volumes from baseline to 12 months were significantly different among groups. Specifically, left amygdala volumes increased over time in healthy adolescents (p=0.008) and adolescents with ADHD (p=0.0009), but not in adolescents with bipolar disorder (p=0.3). Right amygdala volume increased over time in adolescents with ADHD (p<0.001), but not in healthy adolescents nor in adolescents with bipolar disorder (p=0.1 and p=0.3, respectively). In adolescents with bipolar disorder, baseline total amygdala volume was significantly greater in those who subsequently achieved symptomatic recovery as compared to those who did not achieve recovery (p=0.02). Conclusions Adolescents with mania fail to exhibit normal increases in amygdala volume that occur during healthy adolescent neurodevelopment.

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“…One research group has reported that higher IQ is associated with higher levels of NAA and lower levels of Cho in parietal-occipital white matter (Jung et al, 1999; Jung, Yeo, Chiulli, Sibbitt, & Brooks, 2000). A different study investigated the relationship between amygdala volume and intellectual ability and reported negative findings (Amat et al, 2008). Based on these reports, we suggest that the relationship between NAA and IQ in the controls most likely reflects general neural functioning rather than individual differences within cellular properties of the amygdala specifically.…”

Section: Discussionmentioning

confidence: 99%

Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder

Kleinhans

Richards

Weaver

et al. 2009

J Autism Dev Disord

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Amygdala dysfunction has been proposed as a critical contributor to social impairment in autism spectrum disorders (ASD). The current study investigated biochemical abnormalities in the amygdala in 20 high functioning adults with autistic disorder or Asperger’s disorder and 19 typically developing adults matched on age and IQ. Magnetic resonance spectroscopy was used to measure n-acetyl aspartate (NAA), creatine/phosphocreatine (Cre), choline/choline containing compounds (Cho), and Myoinositol (mI) in the right and left amygdala. There were no significant between-group differences in any of the metabolites. However, NAA and Cre levels were significantly correlated to clinical ratings on the Autism Diagnostic Interview-Revised. This suggests that altered metabolite levels in the amygdala may be associated with a more severe early developmental course in ASD.

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Correlates of intellectual ability with morphology of the hippocampus and amygdala in healthy adults

Cited by 45 publications

References 79 publications

Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: The effect on cognitive functioning

Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: The effect on cognitive functioning

Progression of Amygdala Volumetric Abnormalities in Adolescents After Their First Manic Episode

Brief Report: Biochemical Correlates of Clinical Impairment in High Functioning Autism and Asperger’s Disorder

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