Correlates of HCV seropositivity among familial contacts of HCV positive patients

Torre, Giuseppe La; Miele, Luca; Mannocci, Alice; Chiaradia, Giacomina; Berloco, Filippo; Gabrieli, M.L.; Gasbarrini, Giovanni; Ficarra, Maria Giovanna; Matera, Antônio; Ricciardi, Walter; Grieco, Antonio

doi:10.1186/1471-2458-6-237

Cited by 23 publications

(18 citation statements)

References 36 publications

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“…Our prevalence is found to be higher than some others, for example the studies done by Mahmoud et al, Tibbs et al, La Torre et al and Sood et al, where the prevalence was 13.7%, 16%, 8.9% and 16%, respectively [21][22][23][24] . This noted difference may be attributed to the nonsimilar cultures and behavioral patterns of the studied populations, as well as from translocation from rural to urban areas.…”

Section: Discussioncontrasting

confidence: 56%

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Goweda¹,

Rady²

2016

Journal of Gastroenterology and Hepatology Research

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BACKGROUND: Hepatitis C virus (HCV) is a major cause of chronic hepatitis and is considered as a worldwide problem. Egypt has the highest HCV prevalence in the world. The Centers for Disease Control and Prevention(CDC) recommend HCV screening for all adults at high risk of infection. AIM: To determine the prevalence of HCV seropositivity among household contacts of HCV positive patients and study their habits. METHODS: A cross sectional study was conducted in Beltag; a rural village affiliated to Nile Delta. Interviewed questionnaire was used including sociodemographic data and HCV risk factors information.All household contacts were assessed for HCV infection by testing for anti-HCV antibody using a commercial ELISA. RESULTS: 102ofHCV hepatitis patients and 360 of their household contacts were included in the study. The prevalence of HCV seropositivity among household contacts was 35%.78(61.9%) of seropositive contacts were over forty years old, 42(33.3%) received parenteral anti-schistosomal therapy, 72(57.1%) helped family HCV patients during bleeding episodes. Logistical regression showed that the most significant variable associated independently to HCV seropositivity in patients' contacts was helping HCV patients during bleeding episodes (OR = 7.262;, p = 0.000). CONCLUSION:This study approximates the findings of other studies which reported a high prevalence seropositivity among HCV patient's contacts. Help HCV patients during bleeding episodes is the most significant risk factor for intrafamilial HCV transmission.

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Section: Discussioncontrasting

confidence: 56%

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Goweda¹,

Rady²

2016

Journal of Gastroenterology and Hepatology Research

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“…In some studies, the length of the marriage18 40 49 50 was demonstrated as a risk factor for serum positivity, while in other studies33 47 48 such datum was not confirmed. The study by Vandelli51 excluded the intrafamilial transmission in the couples followed up for a 10-year average period.…”

Section: Discussionmentioning

confidence: 94%

“…Eighteen studies were thereafter excluded: one was a review on HCV epidemiology in childhood, five investigated risk factors for acquiring infection in general, three regarded other hepatic viruses, two evaluated cancer and cirrhosis in HCV patients, six focused on groups of patients other than households and one was about antiviral development. Thus, 9 studies were selected18 28–35 but, overall, 25 studies about HCV intrafamilial transmission in Italy were finally chosen18 28–51 because of the reading of the references of the same nine studies. All the studies were cross-sectional and written in English.…”

Section: Resultsmentioning

confidence: 99%

“…In some studies, no association was found between the risk for HCV transmission and the severity and degree of liver disease in index cases18 31 49; however, this could be interpreted as a cohort effect phenomenon because other authors showed data to support the correlation between severity of liver disease and risk for infection in the relatives. In Scotto's study,49 5 out of 31 partners of index cases with chronic liver disease (CLD) were anti-HCV positive compared to 2 out of 42 partners of asymptomatic subjects (16.1% vs 4.8%).…”

Section: Discussionmentioning

confidence: 98%

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Intrafamilial transmission of hepatitis C virus in Italy: a systematic review

Waure

Cefalo

Chiaradia

et al. 2009

Journal of Epidemiology & Community Health

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“…However, at least 50% of all HCV-positive patients do not have a clear history of parenteral or other risk factors 5. In areas with a high prevalence, intrafamilial transmission is suggested to play an important role.…”

Section: Introductionmentioning

confidence: 99%

Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt

Omar

Metwally

Elfeky

et al. 2017

HMER

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Background: Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Although an effective HCV treatment program has been adopted, it is estimated that the number of newly reported cases in Egypt is still high. Intrafamilial transmission may play a role in the high prevalence of HCV in Egypt. Identification of risk factors for the transmission of HCV may help in decreasing its prevalence and eliminating its infection. Aim: The aim of this study was to estimate the prevalence of HCV infection among the household contacts of HCV patients and identify the possible risk factors associated with intrafamilial transmission. Methods: This study was designed as a cohort study of 90 families of patients with confirmed chronic HCV and 38 families of non-HCV-infected persons. Diagnosis of HCV infection was performed by detection of HCV antibodies by fourth-generation enzyme-linked immunosorbent assay and confirmed by HCV RNA polymerase chain reaction. A pre-prepared questionnaire on risk factors was filled out by the participants. The prevalence of HCV was calculated, and univariate and multivariate analyses were carried out to identify the independent risk factors. Results: Among 90 positive-index families, 32 (35.6%) had contact persons with HCV infection compared to two of 38 (5.3%) negative-index families (P < 0.001, odds ratio [OR] = 9.9). Out of 257 index-positive contacts, 38 (14.8%) were infected compared to three of 75 (4%) of index-negative contacts (P = 0.01, OR = 4.3). Infection was associated with older age (6.9% of those aged <20 years, 10.4% of those aged 20-39 years, and 22% of those aged ≥40 years were infected) (P = 0.007). Husbands of infected wives were at a higher risk (33% infected) than wives (13.5%) and sons (16.9%) (P < 0.001). A history of hepatic encephalopathy was the independent predictor of intrafamilial transmission (P < 0.001, OR = 5.4). Conclusion: Intrafamilial transmission was found to possibly play a major role in the high prevalence of HCV in Egypt. Transmission was associated with older age and contact with patients with hepatic encephalopathy and was high among husbands of infected wives.

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Correlates of HCV seropositivity among familial contacts of HCV positive patients

Abstract: Background: Determinants of intrafamilial HCV transmission are still being debated. The aim of this study is to investigate the correlates of HCV seropositivity among familial contacts of HCV positive patients in Italy.

Cited by 23 publications

References 36 publications

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Household Contacts of HCV Patients at Beltag Village, Egypt; Seropositivity and Habits

Intrafamilial transmission of hepatitis C virus in Italy: a systematic review

Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt

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