Correlates Of Endothelial Function And The Peak Systolic Blood Pressure Response To A Graded Maximal Exercise Test

Olson, Kayla M.; Augeri, Amanda L.; Kostek, Matthew C.; Tsongalis, Gregory J.; Seip, Richard L.; Maresh, Carl M.; Thompson, Paul D.; Pescatello, Linda S.

doi:10.1249/01.mss.0000354776.14926.46

Cited by 7 publications

(11 citation statements)

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“…6,7 Although the mechanisms linking aberrant BP elevation during exercise and adverse outcome are not yet completely understood, recent studies in various clinical settings have indicated that pathophysiological changes and its complications are associated with an exaggerated response of BP to exercise even in the early stages of arterial hypertension. [8][9][10][11][12][13][14] The metabolic syndrome (MS) consists of multiple, interrelated risk factors of metabolic origin that appear to promote the development of atherosclerotic cardiovascular diseases in a direct manner. 15 The constellation of metabolic factors may also lead to hypertension and its complications via structural and functional alterations to the vascular wall.…”

Section: Introductionmentioning

confidence: 99%

Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors

et al. 2013

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Metabolic syndrome (MS) may influence vascular reactivity and might cause an excessive increase in blood pressure (BP) during dynamic exercise. We examined this hypothesis in 698 normotensive men (mean age: 43 years) free of cardiovascular disease, diabetes mellitus and renal disease. The response of BP to exercise was assessed by the mean arterial pressure (MAP) during bicycle ergometry. The MAP values were expressed as z-scores normalized to the relative increases in heart rate. High-normal BP, dyslipidemia and hyperglycemia were diagnosed according to the Japan-specific MS criteria. The z-score of MAP was significantly higher in subjects with high-normal BP (+0.57, P<0.001), dyslipidemia (+0.18, P<0.001) and hyperglycemia (+0.24, P<0.001) than in those without MS component (-0.38). In the high-normal BP subjects, the addition of dyslipidemia and/or hyperglycemia was associated with a progressive increase in the z-score of exercise MAP, whereas no such association was observed in the normal-BP subjects (P=0.033, two-way ANOVA). Multivariate regression analysis revealed that a greater number of MS components (β=0.102, P=0.010) was an independent determinant of increased MAP z-score after adjustment for potential confounders, including age (β=0.123, P<0.001), body mass index (β=0.145, P<0.001) and high-normal BP (β=0.410, P<0.001). These results suggest that accumulation of MS components may alter vascular structure and function and lead to the significant elevation of MAP during dynamic exercise even before clinical manifestation of arterial hypertension.

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Section: Introductionmentioning

confidence: 99%

Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors

et al. 2013

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“…The experimental design of FAMuSS has been described elsewhere [6,[15][16][17][18][19][20][21]. The institutional review boards from the 10 institutions involved with the study approved the study protocol and informed consent was obtained from all individuals prior to enrollment.…”

Section: Methodsmentioning

confidence: 99%

“…We have shown NOS3 −786 T>C is associated with resting blood pressure (BP) and the BP response to acute bouts of submaximal [5] and maximal aerobic exercise [6]. Others have reported NOS3 −786 T>C to be associated with resting forearm blood flow [7] and the parasympathetic modulation response to aerobic exercise training [8] as well as the differentiation of elite power from endurance athletes [9].…”

Section: Introductionmentioning

confidence: 99%

Endothelial Nitric Oxide Synthase (NOS3) +894 G>T Associates with Physical Activity and Muscle Performance among Young Adults

Guidry

Kostek

Angelopoulos

et al. 2012

ISRN Vascular Medicine

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Objective. We examined the influence of missense polymorphism, endothelial nitric oxide synthase (NOS3) +894 G>T (rs1799983), on habitual physical activity (PA) and the muscle strength response to resistance training (RT). Methods. Men (n = 354) and women (n = 424; 24.3 ± 8.0 yr) were genotyped. Subjects reported hr/wk in vigorous and light intensity PA and sitting on the Paffenbarger PA questionnaire. One repetition maximum assessed muscle strength. Multivariable and repeated measures ANCOVA tested differences among NOS3 +894 G>T and PA and RT phenotypes by gender. Results. hr/wk in vigorous intensity PA (5.4 ± 1.2 versus 8.3 ± 0.4; P = 0.019), more hr/wk in light intensity PA (42.1 ± 2.4 versus 35.8 ± 0.7; P = 0.011), and less hr/wk sitting (37.6 ± 2.8 versus 45.8 ± 0.9; P = 0.006) than those with the G allele. Women with NOS3 +894 TT gained more absolute (4.4 ± 0.3 versus 3.7 ± 0.8 kg; P = 0.013) and relative (78.3 ± 5.8 versus 61.9 ± 1.8%; P = 0.007) strength than those with the G allele. Conclusions. NOS3 +894 G>T associated with PA among men and women and the muscle strength response to RT among women only. Our findings indicate the need for prospective studies examining the influence of NOS3 variants on PA and the muscle response to RT as well as elucidating underlying mechanistic pathways for the associations observed.

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“…The T-786C variant (rs2070744), a thymidine to cytosine transition mutation, is present in the 5' flanking region of eNOS gene and decreases the promoter activity of eNOS, resulting in decrease of endothelial NO production [6]. It was reported that eNOS T-786C variant is related with resting blood pressure [7] and the blood pressure response to acute event of maximal aerobic exercise [8]. The C allele affects eNOS transcription, which is consistent with reduced NO production [9].…”

Section: Introductionmentioning

confidence: 99%

The Endothelial Nitric Oxide Synthase Gene Variant rs2070744 in Turkish Elite Athletes

Cenikli¹

2016

Eu Clin Anal Med

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48.3%, and 11.6% of control subjects and in 55.7%, 30.7% and 13.4% of elite athletes, respectively. There was not any statistically significant difference in genotype and allele frequencies of T-786C of the eNOS between the elite athlete and the control groups (p>0.05). Discussion: The present study demonstrated that the T-786C variant of the eNOS gene is not associated with study population but larger sample analyses are needed in different groups of elite athletes in order to substantiate these findings.

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Correlates Of Endothelial Function And The Peak Systolic Blood Pressure Response To A Graded Maximal Exercise Test

Cited by 7 publications

References 0 publications

Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors

Increased mean arterial pressure response to dynamic exercise in normotensive subjects with multiple metabolic risk factors

Endothelial Nitric Oxide Synthase (NOS3) +894 G>T Associates with Physical Activity and Muscle Performance among Young Adults

The Endothelial Nitric Oxide Synthase Gene Variant rs2070744 in Turkish Elite Athletes

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