Correlates of brain derived neurotrophic factor in children with attention deficit hyperactivity disorder: A case-control study

Taha, Hala; Elsheshtawy, Eman; Mohamed, Soheir Ibrahim; Al-Azazzy, Omnia; Elsayed, Mahmoud; Ibrahim, Salah Al Sayed

doi:10.4103/ejpsy.ejpsy_17_17

Cited by 6 publications

(5 citation statements)

References 4 publications

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“…Indeed, already in 1878 it was suggested that OC symptoms could be of frequent observation in patients with Schizophrenia (Westphal 1878) and many studies suggested some clinical overlap between OCD and Schizophrenia (Zink 2014). Overexpression of BDNF has been also associated with working memory deficits, increased anxiety-like traits in preclinical models (Govindarajan et al, 2006;Papaleo et al, 2011) as well as with cognitive problems in clinical samples (Yeom et al, 2016;Sayyah et al, 2009;Taha et al, 2017). Indeed, deficits in working memories, and associative learning are commonly encountered in patients with OCD (Chamberlain et al, 2005;Shin et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia

D’Addario

Micale

Bartolomeo

et al. 2017

Schizophrenia Research

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Section: Discussionmentioning

confidence: 99%

A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia

D’Addario

Micale

Bartolomeo

et al. 2017

Schizophrenia Research

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“…Methylphenidate is known to increase dopamine and norepinephrine signaling in the brain [35,36], and both these neurotransmitters contribute to regulating BDNF expression in the hippocampus [37,38]. The few studies that have been conducted in Egypt investigating BDNF levels in ADHD were carried out in small samples [39][40][41], the largest of which included 35 subjects [40]. Therefore, we sought to carry out our study with a larger number of subjects involving 60 patients with ADHD to compare plasma BDNF levels to healthy controls.…”

Section: Introductionmentioning

confidence: 99%

Plasma brain-derived neurotrophic factor (BDNF) in Egyptian children with attention deficit hyperactivity disorder

Ghamry

El‐Sheikh

Meguid

et al. 2021

Middle East Curr Psychiatry

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Background To date, researchers do not fully understand what the aetiology of attention deficit hyperactivity disorder (ADHD) is. As a neurotrophin, the brain-derived neurotrophic factor (BDNF) contributes to the growth of neurons as well as to the efficiency and plasticity of the neuronal synapse, which suggests that it may be a contributing aetiological factor in ADHD. Therefore, we sought to investigate the relationship between ADHD and plasma BDNF, including whether there is an association between BDNF and the degree of severity of ADHD and with ADHD subtypes. Results We found significantly elevated plasma BDNF in ADHD subjects in comparison with healthy subjects, but differences among the three subtypes of ADHD did not reach statistical significance. Conclusion Compared with the control group, elevated plasma BDNF levels were found in the ADHD group, which suggests it may contribute to the aetiology of ADHD.

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“…The published data on BDNF levels, however, showed some variation. Some research indicated greater levels of BDNF in ADHD patients when compared to controls (El Ghamry et al, 2021; Reda et al, 2016; Taha et al, 2017), while other investigations found no appreciable difference in BDNF values when compared to controls (Cubero‐Millan et al, 2017; Scassellati et al, 2014; Şimşek et al, 2016). In contrast, other investigations found that ADHD patients had lower BDNF levels than controls.…”

Section: Discussionmentioning

confidence: 99%

BDNF, proBDNF and proBDNF/BDNF ratio with electroencephalographic abnormalities in children with attention deficit hyperactivity disorder: Possible relations to cognition and severity

El‐Saied,

Afify,

Abdelraouf

et al. 2024

Intl J of Devlp Neuroscience

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Attention deficit hyperactivity disorder (ADHD) with and without subclinical epileptogenic discharges (SED) have been suggested to negatively affect cognitive abilities of children with ADHD. The role of brain‐derived neurotrophic factor (BDNF) and its precursor proBDNF in ADHD is in need of being investigated. The aims were to evaluate the levels of serum BDNF, proBDNF and the proBDNF/BDNF ratio in addition to the potential impacts of SED on the children's cognitive abilities and the severity of ADHD. The included participants with ADHD were 30 children with normal electroencephalogram (EEG) (G1) and 30 children with SED (G2), together with 30 healthy children (G3). The cognitive abilities and severity of the disorder were evaluated. The biochemical measures were determined by ELISA. The presence of coexisting SED and nocturnal enuresis has led to a deleterious effect on cognitive processes but not on the severity. The focal epileptogenic discharge was the most common among children in G2. The levels of BDNF in Groups 1 and 2 were less than those in G3. The higher proBDNF/BDNF ratio could be related to the low BDNF levels rather than high proBDNF levels. The findings of this study highlight the importance of investigating the presence of SED and nocturnal enuresis in children with ADHD. Targeting strengthening of cognitive abilities in children with coexisting ADHD and SED is advised. The role of proBDNF in the pathophysiology of ADHD needs further investigation.

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Correlates of brain derived neurotrophic factor in children with attention deficit hyperactivity disorder: A case-control study

Cited by 6 publications

References 4 publications

A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia

A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia

Plasma brain-derived neurotrophic factor (BDNF) in Egyptian children with attention deficit hyperactivity disorder

BDNF, proBDNF and proBDNF/BDNF ratio with electroencephalographic abnormalities in children with attention deficit hyperactivity disorder: Possible relations to cognition and severity

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