Correlates of bone quality in older persons

Lauretani, Fulvio; Bandinelli, Stefania; Russo, Cosimo Roberto; Maggio, Marcello; Iorio, Angelo Di; Cherubini, Antonio; Maggio, Dario; Ceda, Gian Paolo; Valenti, Giorgio; Guralnik, Jack M.; Ferrucci, Luigi

doi:10.1016/j.bone.2006.03.014

Cited by 46 publications

(44 citation statements)

References 49 publications

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“…Thus, changes in bone mechanical properties may be another mechanism through which proinfl ammatory cytokines could infl uence bone fragility. A recent investigation in the InCHIANTI study examined serum concentrations of IL-6, IL-1β, and TNF-α in relation to quantitative CTderived measures of bone mechanical properties in the tibia [37]. Among this cohort of older men and women, a 1-pg/mL greater IL-1β was signifi cantly associated with a 2.9-mg/cm 3 lower trabecular volumetric BMD in women, indicating lower bone strength.…”

Section: Bone Geometry As a Link Between Cytokines And Fracture Riskmentioning

confidence: 96%

Proinflammatory cytokines and osteoporosis

McLean

2009

Curr Osteoporos Rep

193

115

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Experimental studies indicate that the proinflammatory cytokines interleukin-1, interleukin-6, and tumor necrosis factor-alpha are important regulators of bone resorption and may play an important role in age- and estrogen deficiency-related bone loss. Although the observation of accelerated bone loss in patients with inflammatory disorders supports this mechanism, the role of cytokines in the etiology of osteoporosis has yet to be determined. Elucidation of this potential relationship could not only provide clinicians with an additional tool to identify patients at risk for osteoporosis, but may also inform the development of cytokine-blocking therapies as potential interventions to curb bone loss. Although some epidemiologic studies suggest increases in proinflammatory cytokines are associated with decreased bone mass and greater fracture risk, the totality of evidence is limited and provides no clear indication of which cytokines may be most important for bone health. Additional studies are required to establish if inflammation is an important risk factor for osteoporosis.

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Section: Bone Geometry As a Link Between Cytokines And Fracture Riskmentioning

confidence: 96%

Proinflammatory cytokines and osteoporosis

McLean

2009

Curr Osteoporos Rep

193

115

View full text Add to dashboard Cite

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“…This phenomenon should be the target for interventions aimed at retarding the progression of bone loss in older adults. Future studies are needed to identify the specific effects on hormones and other factors (22) that potentially influence periosteal apposition (1) and endocortical resorption.…”

Section: Figmentioning

confidence: 99%

Longitudinal Changes in BMD and Bone Geometry in a Population-Based Study

Lauretani

Bandinelli

Griswold³

et al. 2008

Journal of Bone and Mineral Research

111

118

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We prospectively examined vBMD and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6-yr follow-up. Periosteal apposition occurred both in men and women. Endocortical resorption causes bone loss in older women despite periosteal apposition.Introduction: To address the hypothesis that age-related changes in BMD and bone geometry may be different in men and women, we prospectively examined volumetric BMD (vBMD) and structural bone parameters assessed by QCT among participants of the InCHIANTI study over a 6-yr follow-up. Materials and Methods: Three hundred forty-five men and 464 women 21-102 yr of age from the InCHIANTI study, a population-based study in Tuscany, Italy, were included. Tibial QCT bone parameters were measured at enrollment (1998)(1999)(2000) and at 3-(2001-2003) and 6-yr (2004-2006) follow-ups. Results: Periosteal apposition occurred both in men and women. The annual rate of bone periosteal apposition was higher in younger than in older men, whereas in women, the rate of apposition was homogenous across age groups. The age-related medullary expansion, expression of endocortical resorption, was significantly higher in women compared with men. In women, but not in men, accelerated endocortical resorption not sufficiently balanced by periosteal apposition caused accelerated loss in cortical bone mass. The cross-sectional moment of inertia decreased progressively over the life span in both sexes. Conclusions: Endocortical resorption causes bone loss in older women despite periosteal apposition. Obtaining a balance between endocortical resorption and periosteal apposition should be the target for interventions aimed to decrease bone loss and prevent osteoporosis in older women.

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“…These factors include inflammatory factors since the age-related increase in pro-inflammatory cytokines is associated with sarcopenia (Schaap et al, 2006) and bone resorption (Lauretani et al, 2006) in older men. Nutritional factors, other than those measured herein, such as protein intake, or the intake of fatty acids for example, might also be involved in the relationship between RASM and FN BMD in adult men (Coin et al, 2008).…”

mentioning

confidence: 99%

Appendicular skeletal muscle mass is the strongest independent factor associated with femoral neck bone mineral density in adult and older men

Blain

Jaussent

Thomas

et al. 2010

Experimental Gerontology

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Appendicular skeletal muscle mass is the strongest independent factor associated with femoral neck bone mineral density in adult and older men, Experimental Gerontology (2010Gerontology ( ), doi: 10.1016Gerontology ( /j.exger.2010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E DM A N U S C R I P T . A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT ABSTRACTThe relationship between bone mass and muscle mass may be due to the site-specific effects of loading on bone in adults and to lifestyle, nutritional, and hormonal factors. Another hypothesis is that the maintenance with aging of both appendicular muscle and bone mass may be determined by factors independent of all these previous factors, including genetic factors. In 160

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Correlates of bone quality in older persons

Cited by 46 publications

References 49 publications

Proinflammatory cytokines and osteoporosis

Proinflammatory cytokines and osteoporosis

Longitudinal Changes in BMD and Bone Geometry in a Population-Based Study

Appendicular skeletal muscle mass is the strongest independent factor associated with femoral neck bone mineral density in adult and older men

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