Correlates of bone mineral density in men of African ancestry: The Tobago Bone Health Study

Hill, Deanna; Cauley, Jane A.; Sheu, Yahtyng; Bunker, Clareann H.; Patrick, Alan L.; Baker, Carol E.; Beckles, Gloria L.; Wheeler, Victor W.; Zmuda, Joseph M.

doi:10.1007/s00198-007-0450-9

Cited by 54 publications

(68 citation statements)

References 31 publications

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“…The computed tomography (CT) scans were obtained as an ancillary study of the Tobago Bone Health Study (TBHS), a population-based prospective study of 2,652 community-dwelling men aged 40 years and older, residing on the Caribbean island of Tobago(27). Participants for the TBHS were recruited without regard to health status and men were eligible if they were ambulatory, not terminally ill and without a bilateral hip replacement.…”

Section: Methodsmentioning

confidence: 99%

Association of circulating sclerostin with vascular calcification in Afro-Caribbean men

Kuipers¹,

Miljkovic²,

Carr³

et al. 2015

Atherosclerosis

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Objective Sclerostin, a Wingless (Wnt) pathway antagonist, is an established regulator of bone mineralization in humans but its potential importance in the regulation of vascular calcification is less clear. Therefore, our objective was to assess the relationship of serum sclerostin levels with coronary and aortic artery calcification (CAC and AAC, respectively) in Afro-Caribbean men on the island of Tobago. Methods Serum sclerostin levels and computed tomography of CAC and AAC were measured in 191 men (age mean(SD): 62.9(8.0)years) recruited without regard to health status. Multivariable logistic regression models were used to assess the cross-sectional association of sclerostin with prevalent arterial calcification. Results Mean(SD) sclerostin was 45.2 pmol/L (15.6 pmol/L). After adjusting for risk factors including age, physical and lifestyle characteristics, comorbidities, lipoproteins and kidney function, 1 SD greater sclerostin level was associated with a 1.61-times (95%CI 1.02–2.53) greater odds of having CAC. Sclerostin was not associated with AAC in any model. Conclusions This is the first study to show that, among Afro-Caribbean men, greater serum sclerostin concentrations were associated with prevalence and extent of CAC. Further studies are needed to better define the role of the Wnt signaling pathway in arterial calcification in humans.

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Section: Methodsmentioning

confidence: 99%

Association of circulating sclerostin with vascular calcification in Afro-Caribbean men

Kuipers¹,

Miljkovic²,

Carr³

et al. 2015

Atherosclerosis

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“…The population-based Tobago Health Study began in 2000 on the Caribbean island of Tobago[24]. Tobago residents are predominantly descendants of West African slaves that settled on the island between 1765 and 1808[25].…”

Section: Methodsmentioning

confidence: 99%

“…In addition, we excluded any man on lipid-lowering medication (N=52; 4%), androgen deprivation therapy (N=41; 3%), or both therapies (N=3) leaving 1289 men for the current analysis. Studies of the correlates of bone[24, 27] and cardiovascular health[28] in Tobago have been published previously. The Institutional Review Boards of the University of Pittsburgh and the Tobago Division of Health and Social Services approved this study.…”

Section: Methodsmentioning

confidence: 99%

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

et al. 2015

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Purpose Studies of lipid and lipoprotein cholesterol associations with bone mineral density (BMD) and bone loss have been inconclusive, and longitudinal data are sparse. Therefore, the aim of this study was to test if fasting serum lipid and lipoprotein cholesterol levels are associated with areal and volumetric BMD and BMD change, Methods We determined the association of serum triglycerides, high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol concentrations with cross-sectional and longitudinal (mean follow-up: 6.1 years) measures of BMD in a cohort of 1289 in African ancestry men (mean age: 56.4 years). Fasting serum triglycerides, HDL and LDL were measured at baseline concurrent with BMD assessments. Dual-energy X-ray absorptiometry was used to quantify integral hip BMD and peripheral quantitative computed tomography at the radius and tibia was used to quantify volumetric BMD. Men were categorized as optimal, borderline or high-risk for triglyceride, HDL and LDL concentrations based on adult treatment panel III guidelines. Results Lower serum triglyceride or LDL and higher HDL concentrations were associated with lower trabecular BMD at baseline (all p<0.05). Similarly, men classified as having optimal levels of LDL, HDL or triglycerides at baseline experienced the greatest integral BMD loss at the hip and trabecular BMD loss at the tibia (all p<0.05), independent of potential confounding factors. Conclusions We found that clinically optimal serum lipid and lipoprotein cholesterol concentrations were associated with accelerated bone loss among Afro-Caribbean men. Further studies are needed to better understand the mechanisms involved and potential clinical significance of these findings.

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“…The replication sample was a randomly selected subset of a larger study of body composition among 2,500 men aged 40 and older (mean age 59 years) on the island of Tobago ( 19 ), with the comprehensive data on anthropometric measures, demographic information, medical history, lifestyle information, and fasting lipoproteins. Men were recruited by word of mouth, via health care workers at the hospital, health centers, or private physicians as well as local advertising by poster, fl yers, and public service announcements.…”

mentioning

confidence: 99%

Association analysis of 33 lipoprotein candidate genes in multi-generational families of African ancestry

Miljkovic

Yerges‐Armstrong

Kuller

et al. 2010

Journal of Lipid Research

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Lipoprotein abnormalities, characterized by elevated levels of LDL cholesterol (LDL-C) and triglycerides (TRIG) and low levels of HDL cholesterol (HDL-C), have a central role in the development of atherosclerotic coronary heart disease (CHD). A recent meta-analysis, including 3,000 individuals with CHD-related deaths, showed that HDL-C and LDL-C are independently associated with CHD risk ( 1 ). There is also considerable evidence that high levels of TRIG are an additional, independent risk factor for CHD ( 2, 3 ), although this is still controversial ( 4 ).Individuals of African ancestry have a more favorable lipoprotein profi le than Caucasians, characterized by lower levels of TRIG and higher levels of HDL-C ( 5-8 ).The mechanisms responsible for these ethnic differences remain to be defi ned. In particular, the differences in TRIG levels are independent of the greater degree of obesity among individuals of African ancestry and several other risk factors and appear to be consistent across African populations in different environments ( 9 ), indicating a possible role of genetic factors. Although genetic factors are important in determining lipoprotein levels, little data Abstract African ancestry individuals have a more favorable lipoprotein profi le than Caucasians, although the mechanisms for these differences remain unclear. We measured fasting serum lipoproteins and genotyped 768 tagging or potentially functional single nucleotide polymorphisms (SNPs) across 33 candidate gene regions in 401 AfroCaribbeans older than 18 years belonging to 7 multi-generational pedigrees (mean family size 51, range 21-113, 3,426 relative pairs). All lipoproteins were signifi cantly heritable ( P < 0.05). Gender-specifi c analysis showed that heritability for triglycerides was much higher ( P < 0.01) in women than in men (women, 0.62 ± 0.18, P < 0.01; men, 0.13 ± 0.17, P > 0.10), but the heritability for LDL cholesterol ( LDL-C) was higher ( P < 0.05) in men than in women (men, 0.79 ± 0.21, P < 0.01; women, 0.39 ± 0.12, P < 0.01). The top 14 SNPs that passed the false discovery rate threshold in the families were then tested for replication in an independent population-based sample of 1,750 Afro-Caribbean men aged 40+ years. Our results revealed signifi cant associations for three SNPs in two genes (rs5929 and rs6511720 in LDLR and rs7517090 in PCSK9 ) and LDL-C in both the family study and in the replication study. Our fi ndings suggest that LDLR and PCSK9 variants may contribute to a variation in LDL-C among African ancestry individuals.

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Correlates of bone mineral density in men of African ancestry: The Tobago Bone Health Study

Abstract: African Caribbean males have the highest BMD on a population level ever reported. Lean mass was the single most important correlate. Variability in BMD/BMAD was also explained by age, mixed African ancestry, anthropometric, lifestyle, and medical factors.

Cited by 54 publications

References 31 publications

Association of circulating sclerostin with vascular calcification in Afro-Caribbean men

Association of circulating sclerostin with vascular calcification in Afro-Caribbean men

Optimal serum cholesterol concentrations are associated with accelerated bone loss in African ancestry men

Association analysis of 33 lipoprotein candidate genes in multi-generational families of African ancestry

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