Correlated variation of chromosomal inversion (3R)C and extra bristles in Drosophila melanogaster

Izquierdo, Jose Antonio Avilés; García‐Vázquez, Eva; Villar, B

doi:10.1038/hdy.1991.78

Cited by 4 publications

(5 citation statements)

References 12 publications

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“…Thus, this pattern strongly suggests that both inversions must likely have carried one or several selection regime-specific favorable alleles. Perhaps consistent with a selective role for In(3R)C , this inversion has previously been found to affect bristle number variation in an artificial selection experiment (Izquierdo et al 1991). …”

Section: Discussionsupporting

confidence: 77%

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Inference of chromosomal inversion dynamics fromPool‐Seq data in natural and laboratory populations ofDrosophila melanogaster

et al. 2013

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Sequencing of pools of individuals (Pool-Seq) represents a reliable and cost-effective approach for estimating genome-wide SNP and transposable element insertion frequencies. However, Pool-Seq does not provide direct information on haplotypes so that, for example, obtaining inversion frequencies has not been possible until now. Here, we have developed a new set of diagnostic marker SNPs for seven cosmopolitan inversions in Drosophila melanogaster that can be used to infer inversion frequencies from Pool-Seq data. We applied our novel marker set to Pool-Seq data from an experimental evolution study and from North American and Australian latitudinal clines. In the experimental evolution data, we find evidence that positive selection has driven the frequencies of In(3R)C and In(3R)Mo to increase over time. In the clinal data, we confirm the existence of frequency clines for In(2L)t, In(3L)P and In(3R)Payne in both North America and Australia and detect a previously unknown latitudinal cline for In(3R)Mo in North America. The inversion markers developed here provide a versatile and robust tool for characterizing inversion frequencies and their dynamics in Pool-Seq data from diverse D. melanogaster populations.

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Section: Discussionsupporting

confidence: 77%

“…Interestingly, and perhaps consistent with a selective role for this inversion, In(3R)C has previously been shown to affect bristle number variation in an artificial selection experiment (Izquierdo et al 1991), yet we did not monitor this phenotype in our experimental evolution study.…”

Section: Implications Of Inversion Polymorphisms For Genome Scans Of ...mentioning

confidence: 72%

Inference of chromosomal inversion dynamics fromPool‐Seq data in natural and laboratory populations ofDrosophila melanogaster

et al. 2013

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“…Several studies have demonstrated the influence of Drosophila chromosome inversions on morphological characters such as wing size and shape in D. mediopunctata (Bitner-Mathé et al, 1995), extra bristles in D. melanogaster (Izquierdo et al, 1991), size-related traits in D. buzzati (Bertrán et al, 1998) and more recently in traits showing clinal variation (Weeks et al, 2002;Calboli et al, 2003). Our results show that the colour polymorphism in D. mediopunctata is associated with chromosome inversions.…”

Section: Chromosome Inversionssupporting

confidence: 51%

“…Ford also proposed that polymorphic adaptations occurred mainly through a genetic architecture in which genes are tightly linked so that they act as a single unit. Inversion polymorphisms in Drosophila have been associated with several fitness-related characters (Rodríguez et al, 1999), behaviour (Dahlgaard et al, 2001) and morphological traits (Izquierdo et al, 1991;Bitner-Mathé et al, 1995;Bertrán et al, 1998). Recently there has been a resurgence of interest in the significance of chromosomal inversions in evolution and speciation.…”

Section: Introductionmentioning

confidence: 99%

Colour polymorphism in Drosophila mediopunctata: genetic (chromosomal) analysis and nonrandom association with chromosome inversions

et al. 2004

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The presence of three dark spots on the abdomen is typical of the tripunctata group of Drosophila, which is the second largest Neotropical group, with 56 species. In some species, such as D. mediopunctata, the colour pattern varies considerably: ranging from flies showing no spots up to flies with three dark spots. In this paper, we present a genetic (chromosomal) analysis of this character showing that this colour polymorphism is genetically determined mainly by the second chromosome. Since this chromosome is the most polymorphic for inversions in this species, we also examined the influence of the inversions on this character. We used strains in which different second chromosomes were placed on the same genetic background and the offspring between them. We found a nonrandom association between the number of spots and the inversions PA0 and PC0. Thus, our results are consistent with the idea that the factors or genes determining a conspicuous polymorphism are likely to be associated, forming a supergene, and this association would be most efficiently accomplished through a chromosome inversion. Moreover, this is the first time that an association between a conspicuous morphological polymorphism and chromosome inversions has been described.

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“…Unfortunately, despite the experimental tractability of the D. melanogaster model, almost nothing is known about the phenotypic effects of other inversions in this species (Lemeunier & Aulard, 1992). One exception is the finding that the frequency of In(3R)C is correlated with bristle number and that artificial selection for increased bristle number increases the frequency of this inversion (García-Vázquez & Sánchez-Refusta, 1988;García-Vázquez, Sanchez-Refusta, & Rubio, 1989;Izquierdo, García-Vázquez, & Villar, 1991). Moreover, a series of studies showed that In(2L)t heterokaryotypes exhibit overdominance with regard to fecundity and fertility in Japanese populations (Watanabe, 1969;Watanabe & Watanabe, 1973;Watanabe, Watanabe, & Oshima, 1976).…”

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confidence: 99%

The adaptive significance of chromosomal inversion polymorphisms inDrosophila melanogaster

2018

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Chromosomal inversions, structural mutations that reverse a segment of a chromosome, cause suppression of recombination in the heterozygous state. Several studies have shown that inversion polymorphisms can form clines or fluctuate predictably in frequency over seasonal time spans. These observations prompted the hypothesis that chromosomal rearrangements might be subject to spatially and/or temporally varying selection. Here, we review what has been learned about the adaptive significance of inversion polymorphisms in the vinegar fly Drosophila melanogaster, the species in which they were first discovered by Sturtevant in 1917. A large body of work provides compelling evidence that several inversions in this system are adaptive; however, the precise selective mechanisms that maintain them polymorphic in natural populations remain poorly understood. Recent advances in population genomics, modelling and functional genetics promise to greatly improve our understanding of this long-standing and fundamental problem in the near future.

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Correlated variation of chromosomal inversion (3R)C and extra bristles in Drosophila melanogaster

Cited by 4 publications

References 12 publications

Inference of chromosomal inversion dynamics fromPool‐Seq data in natural and laboratory populations ofDrosophila melanogaster

Inference of chromosomal inversion dynamics fromPool‐Seq data in natural and laboratory populations ofDrosophila melanogaster

Colour polymorphism in Drosophila mediopunctata: genetic (chromosomal) analysis and nonrandom association with chromosome inversions

The adaptive significance of chromosomal inversion polymorphisms inDrosophila melanogaster

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