Correlated ultrastructural and morphometric studies on the liver during prenatal development of rats

Daimon, Tateo; David, Heinz; Zglinicki, Th. v.; Marx, I

doi:10.1016/s0232-1513(82)80039-x

Cited by 21 publications

(14 citation statements)

References 18 publications

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“…De la Iglesia et al (1976) reported only a small amount of SER membrane at a n early age in human hepatocytes. Daimon et al (1982) reported that the surface and volume densities of SER increase between fetal day 18 and birth in rat hepatocytes. However, these studies did not distinguish between periportal and perivenular hepatocytes.…”

Section: Sermentioning

confidence: 99%

“…The volume density of lipid droplets in rat hepatocytes increases markedly at birth (Daimon et al, 1982). Asada and Kanamura (1979) demonstrated that lipid droplets in mouse hepatocytes, which are evenly distributed throughout the lobule at birth and 1 day postnatally, increase in perivenular cells but decrease in periportal cells after 2 days of age.…”

Section: Glycogen and Lipid Dropletsmentioning

confidence: 99%

“…SER, which is absent during the early fetal period, appears for the first time shortly before birth, i.e., on day 17 of gestation in mouse hepatocytes (Peters et al, 1963) and on day 18 (Daimon et al, 1982;Luzzatto, 1980) or day 20 of gestation (Chedid and Nair, 1974) in rat hepatocytes. After birth, SER increases progressively in amount to the adult level.…”

Section: Sermentioning

confidence: 99%

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Fine structure and function of hepatocytes during development

Kanamura

Kanai

Watanabe

1990

J. Elec. Microsc. Tech.

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This paper reviews the fine structure and function of hepatocytes during fetal and postnatal development. Bile canaliculi develop to a mature appearance during perinatal and early postnatal periods, while bile secretory function is immature at birth and develops during the postnatal period. The rough endoplasmic reticulum is prominent and remains unchanged in amount during development, and the Golgi complex is large from early stages of fetal life. The smooth endoplasmic reticulum (SER) appears shortly before birth and increases in quantity to the adult level after birth. In mouse hepatocytes, Sv (area per unit cytoplasmic volume) of SER increases in perivenular cells between 1 and 10 days of age, although it remains low in periportal cells. Similarly, Sv of total ER increases in both periportal and perivenular cells between 1 and 5 days of age and then becomes greater in perivenular than periportal cells. This suggests that the postnatal increase in the drug-metabolizing capacity occurs predominantly in perivenular hepatocytes. SER proliferates after phenobarbital (PB) administration in both perivenular and periportal cells in 3-, 5-, and 10-day-old mice, and predominantly in perivenular cells in 20-day-old and adult mice. Thus the conspicuous proliferation of SER in perivenular hepatocytes after PB administration, characteristic of adult liver, becomes manifest during postnatal development. In mouse hepatocytes, Vv (volume per unit cytoplasmic volume) of mitochondrial matrix and peroxisomes and Sv of mitochondrial inner membrane and cristae increase in both periportal and perivenular cells between birth and 10 days of age. Then, Vv of mitochondrial matrix remains unchanged in periportal cells but decreases in perivenular cells. In general, the process of postnatal hepatocyte differentiation appears to include several phases of development; cell organelles develop during the early postnatal period, subsequently the cells undergo both functional and structural heterogeneity, and the late postnatal period after weaning is the time for a marked increase in cell size.

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Section: Sermentioning

confidence: 99%

Section: Glycogen and Lipid Dropletsmentioning

confidence: 99%

Section: Sermentioning

confidence: 99%

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Fine structure and function of hepatocytes during development

Kanamura

Kanai

Watanabe

1990

J. Elec. Microsc. Tech.

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“…De la Iglesia et al (1976) observed low amounts of smooth ER membrane at an early age in man. Daimon et al (1982) reported that the surface and volume densities of rough ER remain unchanged but those of smooth ER increase between the 18th fetal day and birth in rats. However, these studies were carried out without distinction between periportal and perihepatic hepatocytes.…”

Section: Area Per Average Mononuclear Hepatocytementioning

confidence: 99%

“…There have been papers describing the quantitative morphology of hepatocyte ER during peri-andor postnatal development (Rohr et al, 1971;Herzfeld et al, 1973;De la Iglesia et al, 1976;Daimon et al, 1982;Asada-Kubota et al, 1982). In these papers, however, measurements were carried out without distinction between periportal and perihepatic hepatocytes on the assumption that all hepatocytes are identical, with the exception of our paper which briefly describes a postnatal change in the volume density of ER (Asada-Kubota et al, 1982).…”

mentioning

confidence: 97%

Peri‐ and postnatal development of heterogeneity in the amounts of endoplasmic reticulum in mouse hepatocytes

1986

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The surface density and area per cell of the endoplasmic reticulum (ER) in periportal and perihepatic hepatocytes from male ddY mice, "17-, 18-, and 19-day-old fetuses," "newborn and 1-, 5-, 10-, and 20-day-old animals," and "adult animals" were analyzed by quantitative electron microscopy. The surface density of rough ER was not significantly different between periportal and perihepatic cells in all age groups examined, except for 19-day-old fetuses in which the value was greater in periportal cells than perihepatic cells. The surface density of smooth ER and total (rough and smooth) ER did not significantly differ between the periportal and perihepatic cells from 17-day-old fetuses to 5-day-old animals. In 10- and 20-day-old and adult animals, the values of smooth and total ER were greater in perihepatic cells than in periportal cells. When the data were expressed as area per cell, the patterns of subacinar distributions hardly differed, but age-related changes differed considerably from the patterns seen in the surface density data. The differences were generally caused by the increase in hepatocyte volume between 20 days of age and adulthood, especially in perihepatic cells, and by the changes in volume during the perinatal period. The results show that differences in the surface density and area per cell of smooth and total ER between periportal and perihepatic hepatocytes evident in adult animals are not present in fetal and newborn animals but arise during postnatal development.

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