Correlated structural and functional brain abnormalities in the default mode network in schizophrenia patients

Salgado‐Pineda, Pilar; Fakra, É.; Delaveau, Pauline; McKenna, Peter J.; Pomarol‐Clotet, Edith; Blin, Olivier

doi:10.1016/j.schres.2010.10.027

Cited by 95 publications

(70 citation statements)

References 17 publications

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“…23,[27][28][29] Finally, the DMN contributes to WM function 6 and is also altered in patients with schizophrenia. 7,54 DMN anomalies in this brain disorder may be associated with altered D2 signaling 16 and dysfunctional interactions with task-related networks. 6 Altered D2 signaling, which may follow DRD2-genotype related differences in D2S/D2L expression ratio, can disrupt the DMN function.…”

Section: Drd2 Effects On Default Mode and Striatal Networkmentioning

confidence: 96%

DRD2 Genotype-Based Variation of Default Mode Network Activity and of Its Relationship With Striatal DAT Binding

Sambataro

Fazio

Taurisano

et al. 2011

Schizophrenia Bulletin

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The default mode network (DMN) comprises a set of brain regions with ''increased'' activity during rest relative to cognitive processing. Activity in the DMN is associated with functional connections with the striatum and dopamine (DA) levels in this brain region. A functional single-nucleotide polymorphism within the dopamine D2 receptor gene (DRD2, rs1076560 G > T) shifts splicing of the 2 D2 isoforms, D2 short and D2 long, and has been associated with striatal DA signaling as well as with cognitive processing. However, the effects of this polymorphism on DMNhave not been explored. The aim of this study was to evaluate the effects of rs1076560 on DMN and striatal connectivity and on their relationship with striatal DA signaling. Twenty-eight subjects genotyped for rs1076560 underwent functional magnetic resonance imaging during a working memory task and 123 55 I-Fluoropropyl-2-beta-carbomethoxy-3-beta(4-iodophenyl) nortropan Single Photon Emission Computed Tomography ([ 123 I]-FP-CIT SPECT) imaging (a measure of dopamine transporter [DAT] binding). Spatial group-independent component (IC) analysis was used to identify DMN and striatal ICs. Within theanteriorDMNIC,GGsubjects had relatively greater connectivity in medial prefrontal cortex (MPFC), which was directly correlated with striatal DAT binding. Within the posterior DMN IC, GG subjects had reduced connectivity in posterior cingulate relative to T carriers. Additionally, rs1076560 genotype predicted connectivity differences within a striatal network, and these changes were correlated with connectivity in MPFC and posterior cingulate within the DMN. These results suggest that genetically determined D2 receptor signaling is associated with DMN connectivity and that these changes are correlated with striatal function and presynaptic DA signaling.

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Section: Drd2 Effects On Default Mode and Striatal Networkmentioning

confidence: 96%

DRD2 Genotype-Based Variation of Default Mode Network Activity and of Its Relationship With Striatal DAT Binding

Sambataro

Fazio

Taurisano

et al. 2011

Schizophrenia Bulletin

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“…This has been found in the medial frontal cortex (Pomarol-Clotet et al 2008 ;Whitfield-Gabrieli et al 2009 ;Milanovic et al 2011), sometimes along with failure of deactivation in the posterior cingulate cortex (Salgado-Pineda et al 2011 ;Schneider et al 2011). Because these regions form two main nodes of the default mode network, which is a series of interconnected brain regions that are metabolically active at rest but whose activity reduces during performance of a wide range of cognitive tasks Raichle et al 2001), this finding has been interpreted as indicating default mode network dysfunction in schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Brain functional abnormality in schizo-affective disorder: an fMRI study

et al. 2012

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Background. Schizo-affective disorder has not been studied to any significant extent using functional imaging. The aim of this study was to examine patterns of brain activation and deactivation in patients meeting strict diagnostic criteria for the disorder.Method. Thirty-two patients meeting Research Diagnostic Criteria (RDC) for schizo-affective disorder (16 schizomanic and 16 schizodepressive) and 32 matched healthy controls underwent functional magnetic resonance imaging (fMRI) during performance of the n-back task. Linear models were used to obtain maps of activations and deactivations in the groups.Results. Controls showed activation in a network of frontal and other areas and also deactivation in the medial frontal cortex, the precuneus and the parietal cortex. Schizo-affective patients activated significantly less in prefrontal, parietal and temporal regions than the controls, and also showed failure of deactivation in the medial frontal cortex. When task performance was controlled for, the reduced activation in the dorsolateral prefrontal cortex (DLPFC) and the failure of deactivation of the medial frontal cortex remained significant.Conclusions. Schizo-affective disorder shows a similar pattern of reduced frontal activation to schizophrenia. The disorder is also characterized by failure of deactivation suggestive of default mode network dysfunction.

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“…DMN dysfunction has been widely described in schizophrenia even if a coherent theory regarding its role in schizophrenia is far from being fully understood. Some authors report a failure in deactivation of the DMN (hyperactivation and hyperconnectivity of the default network) during different cognitive tasks and during rest [19,20]. Resting state in schizophrenia has been less deeply investigated compared to task-related activation [21].…”

Section: Discussionmentioning

confidence: 99%

Brain Metabolism in Substance-Induced Psychosis and Schizophrenia: A Preliminary PET Study

et al. 2014

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Introduction: The relation between schizophrenia and cannabis abuse has been widely discussed from etiopathogenetic, psychopathological and neurometabolic points of view. Relatively little has been written about the differences between schizophrenia with co-occurrent cannabis abuse and substance-induced psychotic disorder (SIPD). Given these premises, our study aims to investigate the psychopathological and neurometabolic features of these clinical entities. Methods: We enrolled patients experiencing an acute psychotic episode, affected either by schizophrenia with or without cannabis abuse (SCZ +/- CA; n = 5 and n = 5, respectively) with recent onset (<5 years of illness) or by SIPD (n = 6), as diagnosed by the Structured Clinical Interview for DSM-IV Axis I. Patients affected by SIPD were all cannabis abusers. All patients were assessed with the PANSS (Positive and Negative Scale for Schizophrenia), urinary toxicological tests and brain 18-FDG-PET scanning in resting condition. Statistical analysis (ANOVA) was performed with Statistical Parametric Mapping SPM8 and Scenium software. Results: Bilateral hypermetabolism in the posterior cingulum and the precuneus (p < 0.001) was observed in SIPD patients compared to patients with schizophrenia, with or without cannabis abuse. Conclusions: Our preliminary PET findings suggest that substance abuse may cause increased brain metabolism in patients with induced psychosis but not in those with schizophrenia. These differences in brain metabolism were found in the posterior cingulum and precuneus, which are two core regions of the default mode network in humans. © 2014 S. Karger AG, Basel

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Correlated structural and functional brain abnormalities in the default mode network in schizophrenia patients

Cited by 95 publications

References 17 publications

DRD2 Genotype-Based Variation of Default Mode Network Activity and of Its Relationship With Striatal DAT Binding

DRD2 Genotype-Based Variation of Default Mode Network Activity and of Its Relationship With Striatal DAT Binding

Brain functional abnormality in schizo-affective disorder: an fMRI study

Brain Metabolism in Substance-Induced Psychosis and Schizophrenia: A Preliminary PET Study

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