Correlated ionisations in two spatially separated nanometric volumes within the track structure of 241Am alpha particles: comparison with Monte Carlo simulations

ICRU Report 98, Stochastic Nature of Radiation Interactions: Microdosimetry

“…The Geant4-DNA platform has since been applied in many studies of damage to the DNA molecule and its higher-order structures in mammalian cells (Figs. 9.17 and 9.18) and other organisms exposed to many radiation types, including those of interest in radiotherapy, space travel, and radiobiology (Chatzipapas et al, 2020;Dominguez-Kondo et al, 2021;Dos Santos et al, 2020;Henthorn et al, 2017;Hilgers et al, 2022;Incerti et al, 2016;2020;Kyriakou et al, 2021;2022;Lee and Wang, 2019;Margis et al, 2020;Moeini et al, 2020;Mokari et al, Figure 9.15. Illustration of raytracing software available within the PARTRAC (PARticles TRACks) suite of simulation tools for assessing DNA and chromatin damage by radiation (Friedland et al, 2011).…”

“…The Geant4-DNA platform has since been applied in many studies of damage to the DNA molecule and its higher-order structures in mammalian cells (Figs. 9.17 and 9.18) and other organisms exposed to many radiation types, including those of interest in radiotherapy, space travel, and radiobiology (Chatzipapas et al , 2020; 2021; 2023; Dominguez-Kondo et al , 2021; Dos Santos et al , 2020; Henthorn et al , 2017; Hilgers et al , 2022; Incerti et al , 2016; 2020; Kyriakou et al , 2021; 2022; Lee and Wang, 2019; Margis et al , 2020; Moeini et al , 2020; Mokari et al , 2020; Sakata et al , 2019; Tang et al , 2020; Thibault et al , 2022; Thompson et al , 2022). Development of the Geant4-DNA platform for radiobiological applications included incorporation of a feature allowing for prediction of DNA rejoining kinetics and corresponding cell surviving fraction as a function of time.…”