Correctly timed coasting reduces the risk of ovarian hyperstimulation syndrome and gives good cycle outcome in an in vitro fertilization program

Grochowski, D; WołzynSki, S.; Kuczyński, Waldemar; Domitrz, Jan; Szamatowicz, Jacek; Szamatowicz, M

doi:10.1080/713602832

Cited by 9 publications

(9 citation statements)

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“…Coasting is a valuable strategy for OHSS prevention but has recognized limitations, because it does not eliminate OHSS and may result in compromised cycle outcomes (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(41)(42)(43). Because OHSS may lead to dangerous and potentially fatal sequelae, complete prevention of this complication would be ideal.…”

mentioning

confidence: 97%

Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting

Diluigi

Engmann

Schmidt

et al. 2010

Fertility and Sterility

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mentioning

confidence: 97%

Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting

Diluigi

Engmann

Schmidt

et al. 2010

Fertility and Sterility

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“…In another study, 112 severely over-stimulated IVF/ intracytoplasmic sperm injection (ICSI) patients were treated with coasting when the serum E2 level was >3000 pg/ml and the leading follicles had attained a diameter of >18 mm [20]. Fertilization failure was noted in six couples, and in another 10 cases it was decided to freeze all of the embryos.…”

Section: Coasting and Ivfmentioning

confidence: 97%

Coasting: What is the Cost?

Aboulghar¹

2010

CWHR

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The objective of this article is to review the current literature on the value of coasting for the prevention of ovarian hyperstimulation syndrome (OHSS). Coasting is a common procedure that is performed in ovarian stimulation cycles at risk of OHSS. Coasting is done by stopping FSH injections and monitoring E2 daily until it drops below 3000 pg/mL then hCG is given. Depriving granulosa cells of the FSH stimulus results in their apoptosis, thus reducing levels of E2 and vascular endothelial growth factor (VEGF linked to the pathogenesis of OHSS). Meanwhile, the small follicles that are dependent on FSH will undergo atresia, while large follicles will not be affected. Coasting is effective in reducing the OHSS rate, but complete prevention is not possible. Prolonged coasting is associated with a significantly lower pregnancy rate.

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“…The appropriate stimulation protocol and gonadotropin dose need to be selected. Even then when patient found hyperstimulated, gonadotropin dose reduction, coasting (withholding gonadotropin), use of cabergoline, cycle cancellation, reduction of hCG dose, deferment of ET and administration of intravenous albumin during or immediately after ovum pick up has been shown to prevent or to reduce the severity of OHSS [6,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36]. Omission of hCG as a result cancellation of cycle is the simplest and safest method of prevention [37].…”

Section: Introductionmentioning

confidence: 99%

Aromatase Inhibitor for Prevention of Ovarian Hyperstimulation Syndrome(OHSS)

Begum¹

2014

Androl Gynecol: Curr Res

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Objective:Our aim was to explore the efficacy of aromatase inhibitor in preventing OHSS. Materials and methods:The study was conducted in Infertility Care and Research Center, Dhaka, Bangladesh. One hundred and twenty patients, who were the potential candidates for developing OHSS, were the target population. They were divided into two groups. One received tab letrozole and other group were selected for coasting for prevention of OHSS.Results: Three patients (5%) in letrozole group developed mild to moderate OHSS and no one developed severe form of OHSS. On the other hand 8.33% developed mild to moderate and 3.33% developed severe form of OHSS in coasting group. Though number of metaphase II oocyte retrieval was similar in two groups, number of grade I egg and grade I embryo were lower in letrozole group. But there was no significant difference in pregnancy rate as transferable embryo was optimum in letrozole group. No cycle was cancelled in either group and no ET was deferred in letrozole group, whereas in 5 (8.33%) cases embryo transfer was deferred in coasting group. Conclusion:The results of this study suggest that without compromising the result of ART aromatase inhibitor can be used to reduce oestrogen level and prevent the severity of OHSS.

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Correctly timed coasting reduces the risk of ovarian hyperstimulation syndrome and gives good cycle outcome in an in vitro fertilization program

Cited by 9 publications

References 0 publications

Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting

Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting

Coasting: What is the Cost?

Aromatase Inhibitor for Prevention of Ovarian Hyperstimulation Syndrome(OHSS)

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