Corrective Effect of Verbascoside on Histomorphological Differences and Oxidative Stress in Colon Mucosa of Rats in Which Colon Ischemia–Reperfusion Injury was Induced

Deger, Ayse Nur; Özyiğit, Filiz; Koçak, Fatma Emel; Bayhan, Zülfü; Zeren, Sezgin; Arık, Özlem; Değer, Hakkı

doi:10.5152/tjg.2021.19747

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…Окислительный стресс -неспецифическое патогенетическое звено воспалительных заболеваний слизистой оболочки полости рта, деструктивно влияющее на ее структуру и функцию [1]. Антиоксидантная терапия способствует устойчивости организма против токсических внутриклеточных реакций, индуцированных свободными радикалами [2]. Синтетические антиоксиданты обладают целым рядом побочных эффектов, в связи с чем природные антиоксиданты вызывают большой интерес у исследователей [3].…”

Section: Introductionunclassified

Exploring the effect of p-tyrosol on vascular morphofunctional changes in lip mucous membrane during experimental stomatitis

Koniaeva,

Baitinger,

Varakuta

et al. 2024

Clin. Exp. Morphology

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Introduction. Oxidative stress is a non-specific pathogenetic link in inflammatory diseases of the oral mucosa, which has a destructive effect on its structure and function. In this regard, natural antioxidants such as (p-tyrosol) are of great interest to researchers. The purpose of this paper was to study the effect of p-tyrosol on the morphofunctional changes in the microcirculatory during experimental stomatitis. Materials and methods. The experiment was carried out on 72 Wistar rats with experimental stomatitis. The animals were divided into four groups, each including 18 subjects: the control (intact rats; group 1 with the burn and no treatment (group 2), with the burn and subsequent administration of p-tyrosol (group 3), and with the burn and subsequent administration of Lidocaine + Chamomile flower extract (group 4). Results. The animals of group 3 had the smallest values of the altered vessels, the precapillary diffusion index and the Kernogan index on days 3, 7, and 12. On the contrary, the numerical density of the unchanged arterioles, venules, and capillaries was the greatest. VEGF expression was detected in group 3 on days 7 and 12, and in group 4, on day 12, thus indicating a more intense angiogenesis. Conclusion. On the background of p-tyrosol administration, there is an increased blood supply in the treated area due to the following factors: a growing density of unchanged microvessels, the germination of the ves-sels in the treated area, and induced angiogenesis.

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Section: Introductionunclassified

Exploring the effect of p-tyrosol on vascular morphofunctional changes in lip mucous membrane during experimental stomatitis

Koniaeva,

Baitinger,

Varakuta

et al. 2024

Clin. Exp. Morphology

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“…For the moment, research has shown that UC is closely related to the imbalance of oxidative stress response. Oxidative stress will overexpress oxygen free radicals, causing damage to fat, protein, and DNA, aggravating or inducing UC (Değer et al, 2021; Finamore et al, 2020). Meanwhile, research has proven that the expression of NF-κB protein in sufferers with UC is notably increased (Glassner et al, 2020; Liu et al, 2022a; Piotrowska et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Fruit of Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils Attenuates DSS-induced Ulcerative Colitis by Adjusting Nrf2/NF-κB Signaling Pathway

Wang

Lei

Han

et al. 2023

Pharmacognosy Magazine

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Background Rosa odorata Sweet var. gigantean (Coll. et Hemsl.) Rehd. et Wils (FOE), a sort of ethnodrug from the Yi nationality called “GU-GONG-GUO,” the root of which has been shown to have the effect of relieving diarrhea with astringents. Whether fruit extract (FOE) has therapeutic properties for related intestinal diseases is unclear. Objectives The study dedicates to expounding the results and mechanisms of FOE for treating ulcerative colitis (UC). Materials and Methods we used dextran sulfate sodium to induce UC in vivo and lipopolysaccharide to stimulate macrophage in vitro for the purpose of exploring and determining the effectiveness and potential mechanism of action of FOE. Results The weight loss ratio and Disease activity index score of FOE administration groups were obviously lower and the colon tissue morphology was significantly relieved. The levels of various proinflammatory cytokines in colon tissue were evaluated to be decreased. Meanwhile, the FOE administration group also alters oxidative stress factor levels. The levels of Nrf2 and HO-1 protein were once distinctly up-regulated, whereas the levels of NF-κB p65, p-IKK α/β, and Keap1 were dose-independently and prominently suppressed by FOE administration. In vitro, FOE significantly reduced the secretion of proinflammatory cytokines and inhibited the oxidant stress injury in macrophage cells induced by macrophage. The relative expressions of NF-κB p65, p-IKK α/β, and Keap1 proteins in FOE groups were memorably down-regulated, while the Nrf2 and HO-1 levels presented as a contrary tendency. Conclusion These results indicated that FOE has shown potential therapeutic efficacy on UC and might be considered an effective anti-inflammatory agent from natural sources.

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Effect of verbascoside against acute kidney injury induced by rhabdomyolysis in rats

Safari Samangani,

Mehri,

Aminifard

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Corrective Effect of Verbascoside on Histomorphological Differences and Oxidative Stress in Colon Mucosa of Rats in Which Colon Ischemia–Reperfusion Injury was Induced

Cited by 6 publications

References 33 publications

Exploring the effect of p-tyrosol on vascular morphofunctional changes in lip mucous membrane during experimental stomatitis

Exploring the effect of p-tyrosol on vascular morphofunctional changes in lip mucous membrane during experimental stomatitis

Fruit of Rosa odorata Sweet var. gigantea (Coll. et Hemsl.) Rehd. et Wils Attenuates DSS-induced Ulcerative Colitis by Adjusting Nrf2/NF-κB Signaling Pathway

Effect of verbascoside against acute kidney injury induced by rhabdomyolysis in rats

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