Corrections to Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography

Abstract

Figure 2. Panels showing ligand binding to LTA4H for compounds described in the manuscript. Enzyme assay IC 50 values are in μM, human whole blood cell assay IC 50 values are in nM when reported, and ligand efficiency (LE) values are in kcal/(mol 3 heavy atom). Compound structures are displayed as yellow stick structures, and LTA4H is displayed in gray. Green mesh corresponds to the F o -F c (difference) electron density at the 3.0σ level of the crystal structure with the compound omitted from the model. Polar contacts with LTA4H and/or bound water molecules are shown as red dashed lines. PDB IDs for each structure are indicated.