Corrections des réponses des détecteurs placés à la sortie d'un CPG

Abstract

RESUME:Le chromatographe par permkation de gel (CPG) muni du seul dktecteur rkfractomktrique est insuffisant pour la caractkrisation des polymeres. Une combinaison de trois dktecteurs, un rkfractomktre, un viscosimktre et un spectrophotomktre infrarouge, est nkcessaire pour analyser un polymhe prksentant une hktkrogknkitk chimique et molkculaire. Malheureusement l'utilisation des rkponses brutes de ces dktecteurs conduit A des rksultats erronks. Dans ce travail les diffkrentes sources d'erreurs sont identifikes et puis corrigkes. SUMMARY:Gel permeation chromatography only fitted with a refractometer is not sufficient for characterization of polymers. In the present study a combination of three detectors, a refractometer, a viscometer, and an IR-spectrophotometer is estimated to be necessary for analyzing polymers showing chemical and molecular heterogeneities. Unfortunately, using the crude results of these detectors for calculations leads to errors, the origins of which are identified and corrected.

Synthetic mRNAs; Their Analogue Caps and Contribution to Disease

“…The representative syndromes that belong to the second category of hamartomas are the family adenomatous polyposis (FAP) and juvenile polyposis syndrome (JPS). FAP is caused by germline mutations in the adenomatous polyposis coli (APC) gene that results in the triggering of upper and lower gastrointestinal polyps and carcinomas, hepatocellular carcinoma and hepatoblastoma (less frequently) [66]. Further, the activation of β-catenin signaling is linked to the loss of APC function that leads to promotion of cellular survival and inhibition of cell death [66].…”

“…FAP is caused by germline mutations in the adenomatous polyposis coli (APC) gene that results in the triggering of upper and lower gastrointestinal polyps and carcinomas, hepatocellular carcinoma and hepatoblastoma (less frequently) [66]. Further, the activation of β-catenin signaling is linked to the loss of APC function that leads to promotion of cellular survival and inhibition of cell death [66]. The β-catenin works through the Wnt/β-catenin pathway to promote cancer [67].…”