Correction: Zhen, Z. et al. NaCl Inhibits Citrinin and Stimulates Monascus Pigments and Monacolin K Production. Toxins 2019, 11, 118

Zhen, Zhixin; Xiong, Xiaoqian; Liu, Yingbao; Zhang, Jialan; Wang, Shaojin; Li, Li; Gao, Mengxiang

doi:10.3390/toxins11040183

Cited by 4 publications

(2 citation statements)

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“…16 It has also been reported that preparation process parameters can influence the final capsule size and size distribution; the main factors are polymerization conditions such as polymer reaction temperature, chemical structure of shell materials, structure of the reactor, agitation speed, and pH. 17 In this experiment, however, the preparation conditions were the same and only the shell and core materials were varied; thus, size variations were mainly driven by the different combinations of monomers, liquid hydrocarbons, and catalysts.…”

Section: Resultsmentioning

confidence: 99%

Study on functional microcapsules containing catalysts for controlling the curing time and temperature of epoxy resin

Hwang

Jeoung

et al. 2019

J of Applied Polymer Sci

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In this study, functional microcapsules (FMs) were designed for controlling the curing time and temperature of epoxy through modifications to thermally expandable microcapsules. The FMs were prepared with a mixture of liquid hydrocarbons and N,N‐dimethylbenzylamine in the core, and acrylonitrile (AN)—methyl methacrylate copolymer or AN–methacrylate copolymer were used for the shell. Since the FMs were intentionally designed to have thermally vulnerable polymeric shells, the catalyst in the core could be released at the designated temperature. Therefore, FMs do not activate in epoxy at room temperature; rather, the FMs only become functional when the epoxy is cured under a heated atmosphere. Released catalyst at the higher temperature was confirmed by pyrolysis gas chromatography–mass spectrometry and optical microscopy. This study shows that the results will depend on the different compositions of liquid hydrocarbons and catalyst. Particle size of the capsules was changed with different ratio of catalyst and liquid hydrocarbon at the core and type of polymeric shell. Differential scanning calorimetry and rheometer results showed that higher catalyst loading resulted lower in crystalline and shear thickening temperature, respectively. Adhesion strength of epoxy containing FMs was analyzed by lap shear strength in order to detect the void effect due to released gas from the FM. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47499.

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Section: Resultsmentioning

confidence: 99%

Study on functional microcapsules containing catalysts for controlling the curing time and temperature of epoxy resin

Hwang

Jeoung

et al. 2019

J of Applied Polymer Sci

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“…ATPAF1 was identified as a key candidate gene through machine learning approaches. As a mitochondria-localized protein, ATPAF1 is essential for ATP synthase assembly and mitochondrial oxidative phosphorylation (Zhou et al, 2021). Although abnormal ATPAF1expression has been reported in asthma and kidney cancer (Schauberger et al, 2011;Bruggemann et al, 2017), its involvement in human diseases remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the shared biological mechanisms and common biomarker APTAF1 of sleep deprivation and mild cognitive impairment using integrated bioinformatics analysis

Liu,

Lu,

Huang

2024

Front. Pharmacol.

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Introduction: The relationship between sleep loss and cognitive impairment has long been widely recognized, but there is still a lack of complete understanding of the underlying mechanisms and potential biomarkers. The purpose of this study is to further explore the shared biological mechanisms and common biomarkers between sleep loss and cognitive impairment.Methods: The mitochondria-related genes and gene expression data were downloaded from the MitoCarta3.0 and Gene Expression Omnibus (GEO) databases. We identified the differentially expressed mitochondrial-related genes by combing the differentially expressed genes (DEGs) in sleep deprivation (SD) and mild cognitive impairment (MCI) datasets with mitochondria-related gene lists. Shared DEGs were then further analyzed for enrichment analysis. Next, the common biomarker was identified using two machine learning techniques and further validated using two independent GEO datasets. Then GSEA and GSVA were conducted to analyze the functional categories and pathways enriched for the common biomarker. Finally, immune infiltration analysis was used to investigate the correlation of immune cell infiltration with the common biomarker in SD and MCI.Results: A total of 32 mitochondrial-related differentially expressed genes were identified in SD and MCI. GO analysis indicated that these genes were significantly enriched for mitochondrial transport, and KEGG analysis showed they were mainly involved in pathways of neurodegenerative diseases. In addition, ATPAF1, which was significantly down-regulated in both SD and MCI, was identified through machine learning algorithms as the common biomarker with favorable diagnostic performance. GSEA and GSVA revealed that ATPAF1 was mainly involved in metabolic pathways, such as oxidative phosphorylation, acetylcholine metabolic process, valine, leucine and isoleucine degradation. Immune infiltration analysis showed that the expression of ATPAF1 was correlated with changes in immune cells, especially those key immune cell types associated with SD and MCI.Discussion: This study firstly revealed that mitochondrial dysfunction may be the common pathogenesis of sleep loss and mild cognitive impairment and identified ATPAF1 as a possible biomarker and therapeutic target involved in SD and MCI.

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Promotion of monacolin K production in Monascus extractive fermentation: the variation in fungal morphology and in the expression levels of biosynthetic gene clusters

et al. 2021

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BACKGROUND: Monacolin K, an important secondary metabolite of Monascus, possesses a cholesterol-lowering effect and is widely used in the manufacture of antihypertensive drugs. In the present study, we constructed an extractive fermentation system by adding non-ionic surfactant and acquired a high monacolin K yield. The mechanism was determined by examining both cell morphology and the transcription levels of the related mokA-I genes in the monacolin K biosynthetic gene cluster. RESULTS: The monacolin K yield was effectively increased to 539.59 mg L −1 during extraction, which was an increase of 386.16% compared to that in the control group fermentation. The non-ionic surfactant showed good biocompatibility with Monascus. Electron scanning microscopy revealed alterations in the morphology of Monascus. The loosened mycelial structure and increased number of cell surface wrinkles were found to be related to the increased cell-membrane permeability and extracellular accumulation of monacolin K. Gene expression levels were measured via a quantitative reverse transciptasepolymerase chain reaction. By contrast, in the control group, mokA, mokB, mokC, mokD and mokF showed higher-level and longer-term expression in the extractive fermentation group, whereas mokE and mokG did not present a similar trend. The expression levels of mokH and mokI, encoding a transcription factor and efflux pump, respectively, were also higher than the control levels.CONCLUSION: The addition of a non-ionic surfactant to Monascus fermentation effectively increases the yield of monacolin K by transforming the fungus morphology and promoting the expression of monacolin K biosynthesis genes.

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Correction: Zhen, Z. et al. NaCl Inhibits Citrinin and Stimulates Monascus Pigments and Monacolin K Production. Toxins 2019, 11, 118

Abstract: The authors wish to make the following correction to their paper [...]

Cited by 4 publications

References 1 publication

Study on functional microcapsules containing catalysts for controlling the curing time and temperature of epoxy resin

Study on functional microcapsules containing catalysts for controlling the curing time and temperature of epoxy resin

Investigation of the shared biological mechanisms and common biomarker APTAF1 of sleep deprivation and mild cognitive impairment using integrated bioinformatics analysis

Promotion of monacolin K production in Monascus extractive fermentation: the variation in fungal morphology and in the expression levels of biosynthetic gene clusters

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